Tags

Type your tag names separated by a space and hit enter

Study of controlled-release floating tablets of dipyridamole using the dry-coated method.
Drug Dev Ind Pharm. 2018 Jan; 44(1):116-124.DD

Abstract

Dipyridamole (DIP), having a short biological half-life, has a narrow absorption window and is primarily absorbed in the stomach. So, the purpose of this study was to prepare controlled-release floating (CRF) tablets of dipyridamole by the dry-coated method. The influence of agents with different viscosity, hydroxypropylmethylcellulose (HPMC) and polyvinylpyrollidon K30 (PVP K30) in the core tablet and low-viscosity HPMC and PVP K30 in the coating layer on drug release, were investigated. Then, a study with a three-factor, three-level orthogonal experimental design was used to optimize the formulation of the CRF tablets. After data processing, the optimized formulation was found to be: 80 mg HPMC K4M in the core tablet, 80 mg HPMC E15 in core tablet and 40 mg PVP K30 in the coating layer. Moreover, an in vitro buoyancy study showed that the optimized formulation had an excellent floating ability and could immediately float without a lag time and this lasted more than 12 h. Furthermore, an in vivo gamma scintigraphic study showed that the gastric residence time of the CRF tablet was about 8 h.

Authors+Show Affiliations

a Department of Pharmaceutics , School of Pharmaceutical Sciences, Shenyang Pharmaceutical University , Shenyang , China.a Department of Pharmaceutics , School of Pharmaceutical Sciences, Shenyang Pharmaceutical University , Shenyang , China.a Department of Pharmaceutics , School of Pharmaceutical Sciences, Shenyang Pharmaceutical University , Shenyang , China.a Department of Pharmaceutics , School of Pharmaceutical Sciences, Shenyang Pharmaceutical University , Shenyang , China.a Department of Pharmaceutics , School of Pharmaceutical Sciences, Shenyang Pharmaceutical University , Shenyang , China.a Department of Pharmaceutics , School of Pharmaceutical Sciences, Shenyang Pharmaceutical University , Shenyang , China.a Department of Pharmaceutics , School of Pharmaceutical Sciences, Shenyang Pharmaceutical University , Shenyang , China.a Department of Pharmaceutics , School of Pharmaceutical Sciences, Shenyang Pharmaceutical University , Shenyang , China.a Department of Pharmaceutics , School of Pharmaceutical Sciences, Shenyang Pharmaceutical University , Shenyang , China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28956647

Citation

Chen, Kai, et al. "Study of Controlled-release Floating Tablets of Dipyridamole Using the Dry-coated Method." Drug Development and Industrial Pharmacy, vol. 44, no. 1, 2018, pp. 116-124.
Chen K, Wen H, Yang F, et al. Study of controlled-release floating tablets of dipyridamole using the dry-coated method. Drug Dev Ind Pharm. 2018;44(1):116-124.
Chen, K., Wen, H., Yang, F., Yu, Y., Gai, X., Wang, H., Li, P., Pan, W., & Yang, X. (2018). Study of controlled-release floating tablets of dipyridamole using the dry-coated method. Drug Development and Industrial Pharmacy, 44(1), 116-124. https://doi.org/10.1080/03639045.2017.1386198
Chen K, et al. Study of Controlled-release Floating Tablets of Dipyridamole Using the Dry-coated Method. Drug Dev Ind Pharm. 2018;44(1):116-124. PubMed PMID: 28956647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of controlled-release floating tablets of dipyridamole using the dry-coated method. AU - Chen,Kai, AU - Wen,Haoyang, AU - Yang,Feifei, AU - Yu,Yibin, AU - Gai,Xiumei, AU - Wang,Haiying, AU - Li,Pingfei, AU - Pan,Weisan, AU - Yang,Xinggang, Y1 - 2017/10/17/ PY - 2017/9/29/pubmed PY - 2018/1/13/medline PY - 2017/9/29/entrez KW - Dipyridamole KW - buoyancy KW - controlled-release floating tablets KW - gamma scintigraphic KW - orthogonal experimental design SP - 116 EP - 124 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 44 IS - 1 N2 - Dipyridamole (DIP), having a short biological half-life, has a narrow absorption window and is primarily absorbed in the stomach. So, the purpose of this study was to prepare controlled-release floating (CRF) tablets of dipyridamole by the dry-coated method. The influence of agents with different viscosity, hydroxypropylmethylcellulose (HPMC) and polyvinylpyrollidon K30 (PVP K30) in the core tablet and low-viscosity HPMC and PVP K30 in the coating layer on drug release, were investigated. Then, a study with a three-factor, three-level orthogonal experimental design was used to optimize the formulation of the CRF tablets. After data processing, the optimized formulation was found to be: 80 mg HPMC K4M in the core tablet, 80 mg HPMC E15 in core tablet and 40 mg PVP K30 in the coating layer. Moreover, an in vitro buoyancy study showed that the optimized formulation had an excellent floating ability and could immediately float without a lag time and this lasted more than 12 h. Furthermore, an in vivo gamma scintigraphic study showed that the gastric residence time of the CRF tablet was about 8 h. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/28956647/Study_of_controlled_release_floating_tablets_of_dipyridamole_using_the_dry_coated_method_ DB - PRIME DP - Unbound Medicine ER -