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Stimulus properties of 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) analogs.
Pharmacol Biochem Behav. 1988 Mar; 29(3):443-9.PB

Abstract

Using a standard two-lever operant procedure, groups of rats were trained to discriminate intraperitoneal doses of the phenylisopropylamines (+)amphetamine (1.0 mg/kg) or racemic 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM; 1.0 mg/kg) from saline using a VI 15-sec schedule of reinforcement for food reward. Once trained, the animals were administered doses of several methylenedioxy analogs (MDAs) of phenylisopropylamine including the N-monomethyl [S(+)MDMA and R(-)MDMA], N-monoethyl [(+/-)MDE, S(+)MDE, and R(-)MDE], and the N-hydroxyl [(+/-)N-OH MDA] derivatives. The DOM-stimulus did not generalize to any of these agents. The amphetamine-stimulus generalized to S(+)MDMA, S(+)N-ethylamphetamine and (+/-)N-hydroxyamphetamine, but not to R(-)MDMA, (+/-)MDE, S(+)MDE, R(-)MDE, or N-OH MDA. The present results are consistent with other reports in the literature suggesting that the psychoactive effects of certain MDA derivatives may be other than simply amphetamine- or DOM-like.

Authors+Show Affiliations

Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond 23298.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2896360

Citation

Glennon, R A., et al. "Stimulus Properties of 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) Analogs." Pharmacology, Biochemistry, and Behavior, vol. 29, no. 3, 1988, pp. 443-9.
Glennon RA, Yousif M, Patrick G. Stimulus properties of 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) analogs. Pharmacol Biochem Behav. 1988;29(3):443-9.
Glennon, R. A., Yousif, M., & Patrick, G. (1988). Stimulus properties of 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) analogs. Pharmacology, Biochemistry, and Behavior, 29(3), 443-9.
Glennon RA, Yousif M, Patrick G. Stimulus Properties of 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) Analogs. Pharmacol Biochem Behav. 1988;29(3):443-9. PubMed PMID: 2896360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stimulus properties of 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) analogs. AU - Glennon,R A, AU - Yousif,M, AU - Patrick,G, PY - 1988/3/1/pubmed PY - 1988/3/1/medline PY - 1988/3/1/entrez SP - 443 EP - 9 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 29 IS - 3 N2 - Using a standard two-lever operant procedure, groups of rats were trained to discriminate intraperitoneal doses of the phenylisopropylamines (+)amphetamine (1.0 mg/kg) or racemic 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM; 1.0 mg/kg) from saline using a VI 15-sec schedule of reinforcement for food reward. Once trained, the animals were administered doses of several methylenedioxy analogs (MDAs) of phenylisopropylamine including the N-monomethyl [S(+)MDMA and R(-)MDMA], N-monoethyl [(+/-)MDE, S(+)MDE, and R(-)MDE], and the N-hydroxyl [(+/-)N-OH MDA] derivatives. The DOM-stimulus did not generalize to any of these agents. The amphetamine-stimulus generalized to S(+)MDMA, S(+)N-ethylamphetamine and (+/-)N-hydroxyamphetamine, but not to R(-)MDMA, (+/-)MDE, S(+)MDE, R(-)MDE, or N-OH MDA. The present results are consistent with other reports in the literature suggesting that the psychoactive effects of certain MDA derivatives may be other than simply amphetamine- or DOM-like. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/2896360/Stimulus_properties_of_1__34_methylenedioxyphenyl__2_aminopropane__MDA__analogs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-3057(88)90001-9 DB - PRIME DP - Unbound Medicine ER -