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Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field.
Am J Ophthalmol. 2017 Dec; 184:63-74.AJ

Abstract

PURPOSE

To compare longitudinal glaucoma progression detection using optical coherence tomography (OCT) and visual field (VF).

DESIGN

Validity assessment.

METHODS

We analyzed subjects with more than 4 semi-annual follow-up visits (every 6 months) in the multicenter Advanced Imaging for Glaucoma Study. Fourier-domain optical coherence tomography (OCT) was used to map the thickness of the peripapillary retinal nerve fiber layer (NFL) and ganglion cell complex (GCC). OCT-based progression detection was defined as a significant negative trend for either NFL or GCC. VF progression was reached if either the event or trend analysis reached significance.

RESULTS

The analysis included 356 glaucoma suspect/preperimetric glaucoma (GS/PPG) eyes and 153 perimetric glaucoma (PG) eyes. Follow-up length was 54.1 ± 16.2 months for GS/PPG eyes and 56.7 ± 16.0 for PG eyes. Progression was detected in 62.1% of PG eyes and 59.8% of GS/PPG eyes by OCT, significantly (P < .001) more than the detection rate of 41.8% and 27.3% by VF. In severity-stratified analysis of PG eyes, OCT had significantly higher detection rate than VF in mild PG (63.1% vs. 38.7%, P < .001), but not in moderate and advanced PG. The rate of NFL thinning slowed dramatically in advanced PG, but GCC thinning rate remained relatively steady and allowed good progression detection even in advanced disease. The Kaplan-Meier time-to-event analyses showed that OCT detected progression earlier than VF in both PG and GS/PPG groups.

CONCLUSIONS

OCT is more sensitive than VF for the detection of progression in early glaucoma. While the utility of NFL declines in advanced glaucoma, GCC remains a sensitive progression detector from early to advanced stages.

Authors+Show Affiliations

Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.Doheny Eye Center and David Geffen School of Medicine at UCLA, Los Angeles, California.Doheny Eye Center and David Geffen School of Medicine at UCLA, Los Angeles, California.Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.University of Southern California Keck School of Medicine, Los Angeles, California.Bascom Palmer Eye Institute, University of Miami, Miami, Florida.New York University Medical Center, New York, New York.Casey Eye Institute, Oregon Health & Science University, Portland, Oregon. Electronic address: davidhuang@alum.mit.edu.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

28964806

Citation

Zhang, Xinbo, et al. "Comparison of Glaucoma Progression Detection By Optical Coherence Tomography and Visual Field." American Journal of Ophthalmology, vol. 184, 2017, pp. 63-74.
Zhang X, Dastiridou A, Francis BA, et al. Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field. Am J Ophthalmol. 2017;184:63-74.
Zhang, X., Dastiridou, A., Francis, B. A., Tan, O., Varma, R., Greenfield, D. S., Schuman, J. S., & Huang, D. (2017). Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field. American Journal of Ophthalmology, 184, 63-74. https://doi.org/10.1016/j.ajo.2017.09.020
Zhang X, et al. Comparison of Glaucoma Progression Detection By Optical Coherence Tomography and Visual Field. Am J Ophthalmol. 2017;184:63-74. PubMed PMID: 28964806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field. AU - Zhang,Xinbo, AU - Dastiridou,Anna, AU - Francis,Brian A, AU - Tan,Ou, AU - Varma,Rohit, AU - Greenfield,David S, AU - Schuman,Joel S, AU - Huang,David, AU - ,, Y1 - 2017/09/28/ PY - 2017/01/26/received PY - 2017/09/18/revised PY - 2017/09/18/accepted PY - 2017/10/2/pubmed PY - 2017/12/5/medline PY - 2017/10/2/entrez SP - 63 EP - 74 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 184 N2 - PURPOSE: To compare longitudinal glaucoma progression detection using optical coherence tomography (OCT) and visual field (VF). DESIGN: Validity assessment. METHODS: We analyzed subjects with more than 4 semi-annual follow-up visits (every 6 months) in the multicenter Advanced Imaging for Glaucoma Study. Fourier-domain optical coherence tomography (OCT) was used to map the thickness of the peripapillary retinal nerve fiber layer (NFL) and ganglion cell complex (GCC). OCT-based progression detection was defined as a significant negative trend for either NFL or GCC. VF progression was reached if either the event or trend analysis reached significance. RESULTS: The analysis included 356 glaucoma suspect/preperimetric glaucoma (GS/PPG) eyes and 153 perimetric glaucoma (PG) eyes. Follow-up length was 54.1 ± 16.2 months for GS/PPG eyes and 56.7 ± 16.0 for PG eyes. Progression was detected in 62.1% of PG eyes and 59.8% of GS/PPG eyes by OCT, significantly (P < .001) more than the detection rate of 41.8% and 27.3% by VF. In severity-stratified analysis of PG eyes, OCT had significantly higher detection rate than VF in mild PG (63.1% vs. 38.7%, P < .001), but not in moderate and advanced PG. The rate of NFL thinning slowed dramatically in advanced PG, but GCC thinning rate remained relatively steady and allowed good progression detection even in advanced disease. The Kaplan-Meier time-to-event analyses showed that OCT detected progression earlier than VF in both PG and GS/PPG groups. CONCLUSIONS: OCT is more sensitive than VF for the detection of progression in early glaucoma. While the utility of NFL declines in advanced glaucoma, GCC remains a sensitive progression detector from early to advanced stages. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/28964806/Comparison_of_Glaucoma_Progression_Detection_by_Optical_Coherence_Tomography_and_Visual_Field_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(17)30404-X DB - PRIME DP - Unbound Medicine ER -