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Concentration of selenium, zinc, copper, Cu/Zn ratio, total antioxidant status and c-reactive protein in the serum of patients with psoriasis treated by narrow-band ultraviolet B phototherapy: A case-control study.
J Trace Elem Med Biol. 2017 Dec; 44:109-114.JT

Abstract

BACKGROUND

Psoriasis is a common, an inflammatory skin disease. Trace elements may play an active role in the pathogenesis of psoriasis.

OBJECTIVE

The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) and c-reactive protein (CRP) in the serum of patients with psoriasis.

METHODS

In this case-control study sixty patients with psoriasis and fifty-eight healthy people were examined. Serum levels of Se, Zn and Cu were determined by atomic absorption spectrometry. Cu/Zn ratio was calculated. TAS was measured spectrophotometrically. CRP was analyzed by immunoturbidimetric method. Clinical activity of psoriasis was evaluated using Psoriasis Area and Severity Index (PASI).

RESULTS

Serum concentration of Se in patients with psoriasis (71.89±16.90μg/L) was lower as compared to the control group (79.42±18.97μg/L) and after NB-UVB. Cu level of patients was higher (1.151±0.320mg/L) as compared to controls (1.038±0.336mg/L), but Zn level did not differ. We observed higher Cu/Zn ratio (p<0.05) in examined patients than in the control group and after NB-UVB. We found decrease TAS before and after NB-UVB. CRP levels was found to be normal range. A significant correlation coefficient between CRP and Cu/Zn was observed.

CONCLUSIONS

The study showed some disturbances in the serum levels of trace elements and TAS in psoriatic patients.

Authors+Show Affiliations

Laboratory of Cosmetology, Medical University of Bialystok, Akademicka 3 St., 15-267 Bialystok, Poland. Electronic address: marta.wacewicz@umb.edu.pl.Department of Bromatology, Medical University of Bialystok,Mickiewicza 2D St., 15-222 Bialystok, Poland.Department of Bromatology, Medical University of Bialystok,Mickiewicza 2D St., 15-222 Bialystok, Poland.Department of Esthetic Medicine, Medical University of Bialystok, Akademicka 3 St., 15-267 Bialystok, Poland; Outdoor-Patients Dermatological Department, Medical University of Bialystok Clinical Hospital, Żurawia 14 St.,15-540 Bialystok, Poland.Outdoor-Patients Dermatological Department, Medical University of Bialystok Clinical Hospital, Żurawia 14 St.,15-540 Bialystok, Poland.Outdoor-Patients Dermatological Department, Medical University of Bialystok Clinical Hospital, Żurawia 14 St.,15-540 Bialystok, Poland.Department of Bromatology, Medical University of Bialystok,Mickiewicza 2D St., 15-222 Bialystok, Poland.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

28965564

Citation

Wacewicz, Marta, et al. "Concentration of Selenium, Zinc, Copper, Cu/Zn Ratio, Total Antioxidant Status and C-reactive Protein in the Serum of Patients With Psoriasis Treated By Narrow-band Ultraviolet B Phototherapy: a Case-control Study." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 44, 2017, pp. 109-114.
Wacewicz M, Socha K, Soroczyńska J, et al. Concentration of selenium, zinc, copper, Cu/Zn ratio, total antioxidant status and c-reactive protein in the serum of patients with psoriasis treated by narrow-band ultraviolet B phototherapy: A case-control study. J Trace Elem Med Biol. 2017;44:109-114.
Wacewicz, M., Socha, K., Soroczyńska, J., Niczyporuk, M., Aleksiejczuk, P., Ostrowska, J., & Borawska, M. H. (2017). Concentration of selenium, zinc, copper, Cu/Zn ratio, total antioxidant status and c-reactive protein in the serum of patients with psoriasis treated by narrow-band ultraviolet B phototherapy: A case-control study. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 44, 109-114. https://doi.org/10.1016/j.jtemb.2017.06.008
Wacewicz M, et al. Concentration of Selenium, Zinc, Copper, Cu/Zn Ratio, Total Antioxidant Status and C-reactive Protein in the Serum of Patients With Psoriasis Treated By Narrow-band Ultraviolet B Phototherapy: a Case-control Study. J Trace Elem Med Biol. 2017;44:109-114. PubMed PMID: 28965564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concentration of selenium, zinc, copper, Cu/Zn ratio, total antioxidant status and c-reactive protein in the serum of patients with psoriasis treated by narrow-band ultraviolet B phototherapy: A case-control study. AU - Wacewicz,Marta, AU - Socha,Katarzyna, AU - Soroczyńska,Jolanta, AU - Niczyporuk,Marek, AU - Aleksiejczuk,Piotr, AU - Ostrowska,Jolanta, AU - Borawska,Maria H, Y1 - 2017/06/27/ PY - 2017/01/03/received PY - 2017/06/21/revised PY - 2017/06/24/accepted PY - 2017/10/3/entrez PY - 2017/10/3/pubmed PY - 2018/5/29/medline KW - C-reactive protein KW - Copper KW - Psoriasis KW - Selenium KW - Total antioxidant status KW - Zinc SP - 109 EP - 114 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 44 N2 - BACKGROUND: Psoriasis is a common, an inflammatory skin disease. Trace elements may play an active role in the pathogenesis of psoriasis. OBJECTIVE: The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) and c-reactive protein (CRP) in the serum of patients with psoriasis. METHODS: In this case-control study sixty patients with psoriasis and fifty-eight healthy people were examined. Serum levels of Se, Zn and Cu were determined by atomic absorption spectrometry. Cu/Zn ratio was calculated. TAS was measured spectrophotometrically. CRP was analyzed by immunoturbidimetric method. Clinical activity of psoriasis was evaluated using Psoriasis Area and Severity Index (PASI). RESULTS: Serum concentration of Se in patients with psoriasis (71.89±16.90μg/L) was lower as compared to the control group (79.42±18.97μg/L) and after NB-UVB. Cu level of patients was higher (1.151±0.320mg/L) as compared to controls (1.038±0.336mg/L), but Zn level did not differ. We observed higher Cu/Zn ratio (p<0.05) in examined patients than in the control group and after NB-UVB. We found decrease TAS before and after NB-UVB. CRP levels was found to be normal range. A significant correlation coefficient between CRP and Cu/Zn was observed. CONCLUSIONS: The study showed some disturbances in the serum levels of trace elements and TAS in psoriatic patients. SN - 1878-3252 UR - https://www.unboundmedicine.com/medline/citation/28965564/Concentration_of_selenium_zinc_copper_Cu/Zn_ratio_total_antioxidant_status_and_c_reactive_protein_in_the_serum_of_patients_with_psoriasis_treated_by_narrow_band_ultraviolet_B_phototherapy:_A_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0946-672X(17)30005-6 DB - PRIME DP - Unbound Medicine ER -