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Fish intake is associated with lower cardiovascular risk in a Mediterranean population: Prospective results from the Moli-sani study.
Nutr Metab Cardiovasc Dis. 2017 Oct; 27(10):865-873.NM

Abstract

BACKGROUND AND AIMS

Fish consumption reportedly reduces the risk of heart disease, but the evidence of cardiovascular advantages associated with fish intake within Mediterranean cohorts is limited. The aim of this study was to test the association between fish intake and risk of composite coronary heart disease (CHD) and stroke in a large population-based cohort adhering to Mediterranean Diet.

METHODS AND RESULTS

Prospective analysis on 20,969 subjects free from cardiovascular disease at baseline, enrolled in the Moli-sani study (2005-2010). Food intake was recorded by the Italian version of the EPIC food frequency questionnaire. Hazard ratios were calculated by using multivariable Cox-proportional hazard models. During a median follow-up of 4.3 years, a total of 352 events occurred (n of CHD = 287 and n of stroke = 66). After adjustment for a large panel of covariates, fish intake ≥4 times per week was associated with 40% reduced risk of composite CHD and stroke (HR = 0.60; 95%CI 0.40-0.90), and with 40% lower risk of CHD (HR = 0.60; 95%CI 0.38-0.94) as compared with subjects in the lowest category of intake (<2 times/week). A similar trend of protection was found for stroke risk although results were not significant (HR = 0.62; 95%CI 0.26-1.51). When fish types were considered, protection against the composite outcome and CHD was confined to fatty fish intake.

CONCLUSIONS

Fish intake was associated with reduced risk of composite fatal and non-fatal CHD and stroke in a general Mediterranean population. The favourable association was likely to be driven by fatty fish.

Authors+Show Affiliations

Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, IS, Italy. Electronic address: marialaura.bonaccio@neuromed.it.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, IS, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, IS, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, IS, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, IS, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, IS, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, IS, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, IS, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, IS, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, 86077 Pozzilli, IS, Italy; Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28967596

Citation

Bonaccio, M, et al. "Fish Intake Is Associated With Lower Cardiovascular Risk in a Mediterranean Population: Prospective Results From the Moli-sani Study." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 27, no. 10, 2017, pp. 865-873.
Bonaccio M, Ruggiero E, Di Castelnuovo A, et al. Fish intake is associated with lower cardiovascular risk in a Mediterranean population: Prospective results from the Moli-sani study. Nutr Metab Cardiovasc Dis. 2017;27(10):865-873.
Bonaccio, M., Ruggiero, E., Di Castelnuovo, A., Costanzo, S., Persichillo, M., De Curtis, A., Cerletti, C., Donati, M. B., de Gaetano, G., & Iacoviello, L. (2017). Fish intake is associated with lower cardiovascular risk in a Mediterranean population: Prospective results from the Moli-sani study. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 27(10), 865-873. https://doi.org/10.1016/j.numecd.2017.08.004
Bonaccio M, et al. Fish Intake Is Associated With Lower Cardiovascular Risk in a Mediterranean Population: Prospective Results From the Moli-sani Study. Nutr Metab Cardiovasc Dis. 2017;27(10):865-873. PubMed PMID: 28967596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish intake is associated with lower cardiovascular risk in a Mediterranean population: Prospective results from the Moli-sani study. AU - Bonaccio,M, AU - Ruggiero,E, AU - Di Castelnuovo,A, AU - Costanzo,S, AU - Persichillo,M, AU - De Curtis,A, AU - Cerletti,C, AU - Donati,M B, AU - de Gaetano,G, AU - Iacoviello,L, AU - ,, Y1 - 2017/08/23/ PY - 2017/04/26/received PY - 2017/07/05/revised PY - 2017/08/07/accepted PY - 2017/10/3/pubmed PY - 2017/10/31/medline PY - 2017/10/3/entrez KW - Cardiovascular risk KW - Cerebrovascular events KW - Coronary heart disease KW - Fatty fish KW - Fish intake KW - Stroke SP - 865 EP - 873 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 27 IS - 10 N2 - BACKGROUND AND AIMS: Fish consumption reportedly reduces the risk of heart disease, but the evidence of cardiovascular advantages associated with fish intake within Mediterranean cohorts is limited. The aim of this study was to test the association between fish intake and risk of composite coronary heart disease (CHD) and stroke in a large population-based cohort adhering to Mediterranean Diet. METHODS AND RESULTS: Prospective analysis on 20,969 subjects free from cardiovascular disease at baseline, enrolled in the Moli-sani study (2005-2010). Food intake was recorded by the Italian version of the EPIC food frequency questionnaire. Hazard ratios were calculated by using multivariable Cox-proportional hazard models. During a median follow-up of 4.3 years, a total of 352 events occurred (n of CHD = 287 and n of stroke = 66). After adjustment for a large panel of covariates, fish intake ≥4 times per week was associated with 40% reduced risk of composite CHD and stroke (HR = 0.60; 95%CI 0.40-0.90), and with 40% lower risk of CHD (HR = 0.60; 95%CI 0.38-0.94) as compared with subjects in the lowest category of intake (<2 times/week). A similar trend of protection was found for stroke risk although results were not significant (HR = 0.62; 95%CI 0.26-1.51). When fish types were considered, protection against the composite outcome and CHD was confined to fatty fish intake. CONCLUSIONS: Fish intake was associated with reduced risk of composite fatal and non-fatal CHD and stroke in a general Mediterranean population. The favourable association was likely to be driven by fatty fish. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/28967596/Fish_intake_is_associated_with_lower_cardiovascular_risk_in_a_Mediterranean_population:_Prospective_results_from_the_Moli_sani_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(17)30198-9 DB - PRIME DP - Unbound Medicine ER -