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Neural Substrate for Metacognitive Accuracy of Tactile Working Memory.
Cereb Cortex. 2017 11 01; 27(11):5343-5352.CC

Abstract

The human prefrontal cortex (PFC) has been shown to be important for metacognition, the capacity to monitor and control one's own cognitive processes. Here we dissected the neural architecture of somatosensory metacognition using navigated single-pulse transcranial magnetic stimulation (TMS) to modulate tactile working memory (WM) processing. We asked subjects to perform tactile WM tasks and to give a confidence rating for their performance after each trial. We circumvented the challenge of interindividual variability in functional brain anatomy by applying TMS to two PFC areas that, according to tractography, were neurally connected with the primary somatosensory cortex (S1): one area in the superior frontal gyrus (SFG), another in the middle frontal gyrus (MFG). These two PFC locations and a control cortical area were stimulated during both spatial and temporal tactile WM tasks. We found that tractography-guided TMS of the SFG area selectively enhanced metacognitive accuracy of tactile temporal, but not spatial WM. Stimulation of the MFG area that was also neurally connected with the S1 had no such effect on metacognitive accuracy of either the temporal or spatial tactile WM. Our findings provide causal evidence that the PFC contains distinct neuroanatomical substrates for introspective accuracy of tactile WM.

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Authors+Show Affiliations

Gogulski J
Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland. Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Aalto 00076, Finland.
Zetter R
Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Aalto 00076, Finland.
Nyrhinen M
Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland. Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Aalto 00076, Finland. Aalto TMS Laboratory, Aalto NeuroImaging, Aalto University, Aalto 00076, Finland.
Pertovaara A
Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.
Carlson S
Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland. Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Aalto 00076, Finland. Aalto TMS Laboratory, Aalto NeuroImaging, Aalto University, Aalto 00076, Finland.

MeSH

AdultDiffusion Magnetic Resonance ImagingFemaleFingersHumansInteroceptionJudgmentMaleMemory, Short-TermMetacognitionNeural PathwaysNeuropsychological TestsPhysical StimulationPrefrontal CortexSomatosensory CortexTouch PerceptionTranscranial Magnetic StimulationYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28968804

Citation

Gogulski, Juha, et al. "Neural Substrate for Metacognitive Accuracy of Tactile Working Memory." Cerebral Cortex (New York, N.Y. : 1991), vol. 27, no. 11, 2017, pp. 5343-5352.
Gogulski J, Zetter R, Nyrhinen M, et al. Neural Substrate for Metacognitive Accuracy of Tactile Working Memory. Cereb Cortex. 2017;27(11):5343-5352.
Gogulski, J., Zetter, R., Nyrhinen, M., Pertovaara, A., & Carlson, S. (2017). Neural Substrate for Metacognitive Accuracy of Tactile Working Memory. Cerebral Cortex (New York, N.Y. : 1991), 27(11), 5343-5352. https://doi.org/10.1093/cercor/bhx219
Gogulski J, et al. Neural Substrate for Metacognitive Accuracy of Tactile Working Memory. Cereb Cortex. 2017 11 1;27(11):5343-5352. PubMed PMID: 28968804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neural Substrate for Metacognitive Accuracy of Tactile Working Memory. AU - Gogulski,Juha, AU - Zetter,Rasmus, AU - Nyrhinen,Mikko, AU - Pertovaara,Antti, AU - Carlson,Synnöve, PY - 2017/04/14/received PY - 2017/10/3/pubmed PY - 2018/6/21/medline PY - 2017/10/3/entrez KW - TMS KW - metacognition KW - tractography KW - working memory SP - 5343 EP - 5352 JF - Cerebral cortex (New York, N.Y. : 1991) JO - Cereb Cortex VL - 27 IS - 11 N2 - The human prefrontal cortex (PFC) has been shown to be important for metacognition, the capacity to monitor and control one's own cognitive processes. Here we dissected the neural architecture of somatosensory metacognition using navigated single-pulse transcranial magnetic stimulation (TMS) to modulate tactile working memory (WM) processing. We asked subjects to perform tactile WM tasks and to give a confidence rating for their performance after each trial. We circumvented the challenge of interindividual variability in functional brain anatomy by applying TMS to two PFC areas that, according to tractography, were neurally connected with the primary somatosensory cortex (S1): one area in the superior frontal gyrus (SFG), another in the middle frontal gyrus (MFG). These two PFC locations and a control cortical area were stimulated during both spatial and temporal tactile WM tasks. We found that tractography-guided TMS of the SFG area selectively enhanced metacognitive accuracy of tactile temporal, but not spatial WM. Stimulation of the MFG area that was also neurally connected with the S1 had no such effect on metacognitive accuracy of either the temporal or spatial tactile WM. Our findings provide causal evidence that the PFC contains distinct neuroanatomical substrates for introspective accuracy of tactile WM. SN - 1460-2199 UR - https://www.unboundmedicine.com/medline/citation/28968804/Neural_Substrate_for_Metacognitive_Accuracy_of_Tactile_Working_Memory_ DB - PRIME DP - Unbound Medicine ER -