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Insights into the CuO nanoparticle ecotoxicity with suitable marine model species.
Ecotoxicol Environ Saf. 2018 Jan; 147:852-860.EE

Abstract

Metal oxide nanoparticles, among them copper oxide nanoparticles (CuO NPs), are widely used in different applications (e.g. batteries, gas sensors, superconductors, plastics and metallic coatings), increasing their potential release in the environment. In aquatic matrix, the behavior of CuO NPs may strongly change, depending on their surface charge and some physical-chemical characteristics of the medium (e.g. ionic strength, salinity, pH and natural organic matter content). Ecotoxicity of CuO NPs to aquatic organisms was mainly studied on freshwater species, few tests being performed on marine biota. The aim of this study was to assess the toxicity of CuO NPs on suitable indicator species, belonging to the ecologically relevant level of consumers. The selected bioassays use reference protocols to identify Effect/Lethal Concentrations (E(L)C), by assessing lethal and sub-lethal endpoints. Mortality tests were performed on rotifer (Brachionus plicatilis), shrimp (Artemia franciscana) and copepod (Tigriopus fulvus). While moult release failure and fertilization rate were studied, as sub-lethal endpoints, on T. fulvus and sea urchin (Paracentrotus lividus), respectively. The size distribution and sedimentation rates of CuO NPs, together with the copper dissolution, were also analyzed in the exposure media. The CuO NP ecotoxicity assessment showed a concentration-dependent response for all species, indicating similar mortality for B. plicatilis (48hLC50 = 16.94 ± 2.68mg/l) and T. fulvus (96hLC50 = 12.35 ± 0.48mg/l), followed by A. franciscana (48hLC50 = 64.55 ± 3.54mg/l). Comparable EC50 values were also obtained for the sub-lethal endpoints in P. lividus (EC50 = 2.28 ± 0.06mg/l) and T. fulvus (EC50 = 2.38 ± 0.20mg/l). Copper salts showed higher toxicity than CuO NPs for all species, with common sensitivity trend as follows: P. lividus ≥ T. fulvus (sublethal endpoint) ≥ B. plicatilis >T. fulvus (lethal endpoint) >A. franciscana. CuO NP micrometric aggregates and high sedimentation rates were observed in the exposure media, with different particle size distributions depending on the medium. The copper dissolution was about 0.16% of the initial concentration, comparable to literature values. The integrated ecotoxicological-physicochemical approach was used to better describe CuO NP toxicity and behavior. In particular, the successful application of ecotoxicological reference protocols allowed to produce reliable L(E)C data useful to identify thresholds and assess potential environmental hazard due to NPs.

Authors+Show Affiliations

Department of Biology, University Tor Vergata, Rome, Italy; Institute for Environmental Protection and Research (ISPRA), Rome, Italy.Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples, Italy.CNR, Institute for Coastal Marine Environment, Section of Taranto, Via Roma 3, Taranto, Italy.Institute for Environmental Protection and Research (ISPRA), Rome, Italy.Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples, Italy; Department of Sciences, University of Basilicata, Potenza, Italy.Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples, Italy.CNR, Institute for Coastal Marine Environment, Section of Taranto, Via Roma 3, Taranto, Italy.Institute for Environmental Protection and Research (ISPRA), Rome, Italy.Institute for Environmental Protection and Research (ISPRA), Rome, Italy.Department of Biology, University Tor Vergata, Rome, Italy.Institute for Environmental Protection and Research (ISPRA), Rome, Italy; Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples, Italy. Electronic address: loredana.manfra@isprambiente.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28968938

Citation

Rotini, A, et al. "Insights Into the CuO Nanoparticle Ecotoxicity With Suitable Marine Model Species." Ecotoxicology and Environmental Safety, vol. 147, 2018, pp. 852-860.
Rotini A, Gallo A, Parlapiano I, et al. Insights into the CuO nanoparticle ecotoxicity with suitable marine model species. Ecotoxicol Environ Saf. 2018;147:852-860.
Rotini, A., Gallo, A., Parlapiano, I., Berducci, M. T., Boni, R., Tosti, E., Prato, E., Maggi, C., Cicero, A. M., Migliore, L., & Manfra, L. (2018). Insights into the CuO nanoparticle ecotoxicity with suitable marine model species. Ecotoxicology and Environmental Safety, 147, 852-860. https://doi.org/10.1016/j.ecoenv.2017.09.053
Rotini A, et al. Insights Into the CuO Nanoparticle Ecotoxicity With Suitable Marine Model Species. Ecotoxicol Environ Saf. 2018;147:852-860. PubMed PMID: 28968938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insights into the CuO nanoparticle ecotoxicity with suitable marine model species. AU - Rotini,A, AU - Gallo,A, AU - Parlapiano,I, AU - Berducci,M T, AU - Boni,R, AU - Tosti,E, AU - Prato,E, AU - Maggi,C, AU - Cicero,A M, AU - Migliore,L, AU - Manfra,L, Y1 - 2017/10/10/ PY - 2017/05/17/received PY - 2017/09/13/revised PY - 2017/09/18/accepted PY - 2017/10/4/pubmed PY - 2018/3/9/medline PY - 2017/10/4/entrez KW - Copepod KW - Nanomaterial toxicity KW - Nanoparticle behavior KW - Rotifer KW - Sea urchin KW - Shrimp SP - 852 EP - 860 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 147 N2 - Metal oxide nanoparticles, among them copper oxide nanoparticles (CuO NPs), are widely used in different applications (e.g. batteries, gas sensors, superconductors, plastics and metallic coatings), increasing their potential release in the environment. In aquatic matrix, the behavior of CuO NPs may strongly change, depending on their surface charge and some physical-chemical characteristics of the medium (e.g. ionic strength, salinity, pH and natural organic matter content). Ecotoxicity of CuO NPs to aquatic organisms was mainly studied on freshwater species, few tests being performed on marine biota. The aim of this study was to assess the toxicity of CuO NPs on suitable indicator species, belonging to the ecologically relevant level of consumers. The selected bioassays use reference protocols to identify Effect/Lethal Concentrations (E(L)C), by assessing lethal and sub-lethal endpoints. Mortality tests were performed on rotifer (Brachionus plicatilis), shrimp (Artemia franciscana) and copepod (Tigriopus fulvus). While moult release failure and fertilization rate were studied, as sub-lethal endpoints, on T. fulvus and sea urchin (Paracentrotus lividus), respectively. The size distribution and sedimentation rates of CuO NPs, together with the copper dissolution, were also analyzed in the exposure media. The CuO NP ecotoxicity assessment showed a concentration-dependent response for all species, indicating similar mortality for B. plicatilis (48hLC50 = 16.94 ± 2.68mg/l) and T. fulvus (96hLC50 = 12.35 ± 0.48mg/l), followed by A. franciscana (48hLC50 = 64.55 ± 3.54mg/l). Comparable EC50 values were also obtained for the sub-lethal endpoints in P. lividus (EC50 = 2.28 ± 0.06mg/l) and T. fulvus (EC50 = 2.38 ± 0.20mg/l). Copper salts showed higher toxicity than CuO NPs for all species, with common sensitivity trend as follows: P. lividus ≥ T. fulvus (sublethal endpoint) ≥ B. plicatilis >T. fulvus (lethal endpoint) >A. franciscana. CuO NP micrometric aggregates and high sedimentation rates were observed in the exposure media, with different particle size distributions depending on the medium. The copper dissolution was about 0.16% of the initial concentration, comparable to literature values. The integrated ecotoxicological-physicochemical approach was used to better describe CuO NP toxicity and behavior. In particular, the successful application of ecotoxicological reference protocols allowed to produce reliable L(E)C data useful to identify thresholds and assess potential environmental hazard due to NPs. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/28968938/Insights_into_the_CuO_nanoparticle_ecotoxicity_with_suitable_marine_model_species_ DB - PRIME DP - Unbound Medicine ER -