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Rutin as Neuroprotective Agent: From Bench to Bedside.
Curr Med Chem. 2019; 26(27):5152-5164.CM

Abstract

Flavonoids are major dietary constituents of plant-based food found ubiquitously in plant kingdom where they are usually present in substantial amounts. Rutin is a flavonol-type polyphenol which consists of the flavonol quercetin and the disaccharide rutinose. Rutin has been reported to exert diverse biological effects such as antitumor and antimicrobial mainly associated to its antioxidant and anti-inflammatory activities. Mental, neurological, and behavioural disorders are an important and growing cause of morbidity. Most of these disorders combine a high prevalence, early onset, progressive clinical course, and impairment of critical brain functions making them a major contributor to the global disease burden. In the present work, the biological in vitro and in vivo effects and the potential therapeutic applications of rutin in neurodegenerative processes are reviewed, as well as their bioavailability and pharmacokinetics, which are essential for a better understanding of its biological effectiveness. Moreover, the present review also provides an overview of the molecular mechanisms through which rutin is proposed to exert its neuroprotective effects.

Authors+Show Affiliations

Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4a Street, 20- 093 Lublin, Poland.Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Viale Ferdinando Stagno d'Alcontres, 31 98166, S.Agata, Messina, Italy.Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4a Street, 20- 093 Lublin, Poland.Department of Molecular Biology, Institute Ruder Boskovic, Bijenicka c. 54, 10000 Zagreb, Croatia.Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.Research Group on Community Nutrition and Oxidative Stress (NUCOX), University of Balearic Islands, E-07122 Palma de Mallorca, Balearic Islands, Spain. CIBEROBN (Physiopathology of Obesity and Nutrition), E-07122 Palma de Mallorca, Balearic Islands, Spain.Department of Biotechnology, Alagappa University, Karaikudi 630 004, Tamil Nadu, India.Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28971760

Citation

Budzynska, Barbara, et al. "Rutin as Neuroprotective Agent: From Bench to Bedside." Current Medicinal Chemistry, vol. 26, no. 27, 2019, pp. 5152-5164.
Budzynska B, Faggio C, Kruk-Slomka M, et al. Rutin as Neuroprotective Agent: From Bench to Bedside. Curr Med Chem. 2019;26(27):5152-5164.
Budzynska, B., Faggio, C., Kruk-Slomka, M., Samec, D., Nabavi, S. F., Sureda, A., Devi, K. P., & Nabavi, S. M. (2019). Rutin as Neuroprotective Agent: From Bench to Bedside. Current Medicinal Chemistry, 26(27), 5152-5164. https://doi.org/10.2174/0929867324666171003114154
Budzynska B, et al. Rutin as Neuroprotective Agent: From Bench to Bedside. Curr Med Chem. 2019;26(27):5152-5164. PubMed PMID: 28971760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rutin as Neuroprotective Agent: From Bench to Bedside. AU - Budzynska,Barbara, AU - Faggio,Caterina, AU - Kruk-Slomka,Marta, AU - Samec,Dunja, AU - Nabavi,Seyed Fazel, AU - Sureda,Antoni, AU - Devi,Kasi Pandima, AU - Nabavi,Seyed Mohammad, PY - 2016/12/16/received PY - 2017/09/20/revised PY - 2017/09/22/accepted PY - 2017/10/4/pubmed PY - 2019/11/27/medline PY - 2017/10/4/entrez KW - Alzheimer's disease KW - antioxidant KW - flavonoid KW - neurodegenerative diseases KW - polyphenols KW - rutin. SP - 5152 EP - 5164 JF - Current medicinal chemistry JO - Curr Med Chem VL - 26 IS - 27 N2 - Flavonoids are major dietary constituents of plant-based food found ubiquitously in plant kingdom where they are usually present in substantial amounts. Rutin is a flavonol-type polyphenol which consists of the flavonol quercetin and the disaccharide rutinose. Rutin has been reported to exert diverse biological effects such as antitumor and antimicrobial mainly associated to its antioxidant and anti-inflammatory activities. Mental, neurological, and behavioural disorders are an important and growing cause of morbidity. Most of these disorders combine a high prevalence, early onset, progressive clinical course, and impairment of critical brain functions making them a major contributor to the global disease burden. In the present work, the biological in vitro and in vivo effects and the potential therapeutic applications of rutin in neurodegenerative processes are reviewed, as well as their bioavailability and pharmacokinetics, which are essential for a better understanding of its biological effectiveness. Moreover, the present review also provides an overview of the molecular mechanisms through which rutin is proposed to exert its neuroprotective effects. SN - 1875-533X UR - https://www.unboundmedicine.com/medline/citation/28971760/Rutin_as_Neuroprotective_Agent:_From_Bench_to_Bedside_ L2 - http://www.eurekaselect.com/156109/article DB - PRIME DP - Unbound Medicine ER -