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Plasma insulin-like growth factor-I/somatomedin-C in acromegaly: correlation with the degree of growth hormone hypersecretion.
J Clin Endocrinol Metab. 1988 Jul; 67(1):69-73.JC

Abstract

We measured plasma insulin-like growth factor I/somatomedin-C (IGF-I/SmC) concentrations and mean 24-h GH secretion serially before and during therapy with the long-acting somatostatin analog SMS 201-995 in 21 patients with acromegaly. When mean plasma GH was elevated above 12.0 +/- 0.6 (+/- SE) micrograms/L, plasma IGF-I/SmC concentrations were uniformly high, but a decline of mean plasma GH below this value was accompanied by a linear decrease in IGF-I/SmC concentrations (r = 0.89; P less than 0.001). Even mildly abnormal mean GH concentrations (greater than 4.6 but less than 10 micrograms/L) were accompanied by high plasma IGF-I/SmC values. The log dose-response interrelation between mean 24-h plasma GH and IGF-I/SmC concentrations was linear (r = 0.86; P less than 0.001). We conclude that 1) an excellent log dose-response correlation between mean 24-h plasma GH and IGF-I/SmC concentrations is present in patients with acromegaly; 2) normalization of plasma IGF-I/SmC occurs only in patients with mean daily GH output within the normal range; and 3) determination of plasma IGF-I/SmC is an accurate indicator of normalcy of GH secretion and should be used in the diagnosis of active acromegaly as well as in monitoring the progress of therapy.

Authors+Show Affiliations

Barkan AL
Department of Internal Medicine, Veterans Administration, Hospital, Ann Arbor, Michigan.
Beitins IZ
No affiliation info available
Kelch RP
No affiliation info available

MeSH

AcromegalyAdolescentAdultAgedCircadian RhythmDelayed-Action PreparationsDose-Response Relationship, DrugFemaleGrowth HormoneHumansInsulin-Like Growth Factor IMaleMiddle AgedOctreotideSecretory RateSomatomedinsSomatostatin

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2897974

Citation

Barkan, A L., et al. "Plasma Insulin-like Growth factor-I/somatomedin-C in Acromegaly: Correlation With the Degree of Growth Hormone Hypersecretion." The Journal of Clinical Endocrinology and Metabolism, vol. 67, no. 1, 1988, pp. 69-73.
Barkan AL, Beitins IZ, Kelch RP. Plasma insulin-like growth factor-I/somatomedin-C in acromegaly: correlation with the degree of growth hormone hypersecretion. J Clin Endocrinol Metab. 1988;67(1):69-73.
Barkan, A. L., Beitins, I. Z., & Kelch, R. P. (1988). Plasma insulin-like growth factor-I/somatomedin-C in acromegaly: correlation with the degree of growth hormone hypersecretion. The Journal of Clinical Endocrinology and Metabolism, 67(1), 69-73.
Barkan AL, Beitins IZ, Kelch RP. Plasma Insulin-like Growth factor-I/somatomedin-C in Acromegaly: Correlation With the Degree of Growth Hormone Hypersecretion. J Clin Endocrinol Metab. 1988;67(1):69-73. PubMed PMID: 2897974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma insulin-like growth factor-I/somatomedin-C in acromegaly: correlation with the degree of growth hormone hypersecretion. AU - Barkan,A L, AU - Beitins,I Z, AU - Kelch,R P, PY - 1988/7/1/pubmed PY - 1988/7/1/medline PY - 1988/7/1/entrez SP - 69 EP - 73 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 67 IS - 1 N2 - We measured plasma insulin-like growth factor I/somatomedin-C (IGF-I/SmC) concentrations and mean 24-h GH secretion serially before and during therapy with the long-acting somatostatin analog SMS 201-995 in 21 patients with acromegaly. When mean plasma GH was elevated above 12.0 +/- 0.6 (+/- SE) micrograms/L, plasma IGF-I/SmC concentrations were uniformly high, but a decline of mean plasma GH below this value was accompanied by a linear decrease in IGF-I/SmC concentrations (r = 0.89; P less than 0.001). Even mildly abnormal mean GH concentrations (greater than 4.6 but less than 10 micrograms/L) were accompanied by high plasma IGF-I/SmC values. The log dose-response interrelation between mean 24-h plasma GH and IGF-I/SmC concentrations was linear (r = 0.86; P less than 0.001). We conclude that 1) an excellent log dose-response correlation between mean 24-h plasma GH and IGF-I/SmC concentrations is present in patients with acromegaly; 2) normalization of plasma IGF-I/SmC occurs only in patients with mean daily GH output within the normal range; and 3) determination of plasma IGF-I/SmC is an accurate indicator of normalcy of GH secretion and should be used in the diagnosis of active acromegaly as well as in monitoring the progress of therapy. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/2897974/Plasma_insulin_like_growth_factor_I/somatomedin_C_in_acromegaly:_correlation_with_the_degree_of_growth_hormone_hypersecretion_ DB - PRIME DP - Unbound Medicine ER -