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Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses.
Vet Dermatol. 2018 Feb; 29(1):51-e22.VD

Abstract

BACKGROUND

Insect bite hypersensitivity (IBH) is an allergic dermatitis of horses caused by bites of Culicoides spp. IBH does not occur in Iceland because of the absence of Culicoides, but the prevalence is high in horses imported from Iceland to environments where Culicoides are present.

HYPOTHESIS/OBJECTIVE

Test, in a longitudinal study before and after Culicoides exposure, whether a primary sensitizing Culicoides allergen can be identified and if an increase of allergen-specific immunoglobulin (Ig)E or IgG subclasses precedes clinical signs of IBH.

ANIMALS

Thirty two horses imported from Iceland to Europe; 16 developed IBH and 16 remained healthy.

METHODS

Determination of IgE and IgG subclasses against recombinant (r)-Culicoides allergens and Culicoides extract in sera taken before first exposure to Culicoides and yearly over a period of 3-4 years.

RESULTS

Before Culicoides exposure, there were no significant differences in Culicoides-specific serum IgE levels between horse that developed IBH or remained healthy. Culicoides exposure induced an individual IgE response pattern (to a median of 4.5 r-allergens) in the IBH but not in the healthy end-point group. The increase in serum IgE levels to Culicoides r-allergens was concurrent with the initial onset of clinical signs of IBH. IBH-affected horses displayed significantly higher allergen-specific IgG1 and IgG5 levels than healthy controls. Recombinant Culicoides obsoletus 1 (Cul o1) and Cul o3-specific IgG5 was significantly higher in the IBH compared to the healthy end-point group, before clinical signs of IBH.

CONCLUSION/CLINICAL RELEVANCE

Allergen-specific serum IgE cannot be used as predictor for IBH, whereas allergen-specific IgG5 levels may have a predictive value.

Authors+Show Affiliations

Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Berne, Länggass-Strasse 124, Berne, 3012, Switzerland.Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Berne, Länggass-Strasse 124, Berne, 3012, Switzerland. Department of Zoonoses, Faculty of Veterinary Medicine, Cairo University, PO Box 12211, Giza, Egypt.Institute for Experimental Pathology, Biomedical Center, University of Iceland, Keldur, Keldnavegur 3, Reykjavik, 112, Iceland.Swiss Institute of Allergy and Asthma Research (SIAF), Obere Strasse 22, Davos, 7270, Switzerland.Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Berne, Länggass-Strasse 124, Berne, 3012, Switzerland.Institute for Experimental Pathology, Biomedical Center, University of Iceland, Keldur, Keldnavegur 3, Reykjavik, 112, Iceland.Institute for Experimental Pathology, Biomedical Center, University of Iceland, Keldur, Keldnavegur 3, Reykjavik, 112, Iceland.Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Berne, Länggass-Strasse 124, Berne, 3012, Switzerland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28980353

Citation

Ziegler, Anja, et al. "Longitudinal Analysis of Allergen-specific IgE and IgG Subclasses as Potential Predictors of Insect Bite Hypersensitivity Following First Exposure to Culicoides in Icelandic Horses." Veterinary Dermatology, vol. 29, no. 1, 2018, pp. 51-e22.
Ziegler A, Hamza E, Jonsdottir S, et al. Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses. Vet Dermatol. 2018;29(1):51-e22.
Ziegler, A., Hamza, E., Jonsdottir, S., Rhyner, C., Wagner, B., Schüpbach, G., Svansson, V., Torsteinsdottir, S., & Marti, E. (2018). Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses. Veterinary Dermatology, 29(1), 51-e22. https://doi.org/10.1111/vde.12493
Ziegler A, et al. Longitudinal Analysis of Allergen-specific IgE and IgG Subclasses as Potential Predictors of Insect Bite Hypersensitivity Following First Exposure to Culicoides in Icelandic Horses. Vet Dermatol. 2018;29(1):51-e22. PubMed PMID: 28980353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses. AU - Ziegler,Anja, AU - Hamza,Eman, AU - Jonsdottir,Sigridur, AU - Rhyner,Claudio, AU - Wagner,Bettina, AU - Schüpbach,Gertraud, AU - Svansson,Vilhjalmur, AU - Torsteinsdottir,Sigurbjorg, AU - Marti,Eliane, Y1 - 2017/10/05/ PY - 2017/07/08/accepted PY - 2017/10/6/pubmed PY - 2018/8/1/medline PY - 2017/10/6/entrez SP - 51 EP - e22 JF - Veterinary dermatology JO - Vet. Dermatol. VL - 29 IS - 1 N2 - BACKGROUND: Insect bite hypersensitivity (IBH) is an allergic dermatitis of horses caused by bites of Culicoides spp. IBH does not occur in Iceland because of the absence of Culicoides, but the prevalence is high in horses imported from Iceland to environments where Culicoides are present. HYPOTHESIS/OBJECTIVE: Test, in a longitudinal study before and after Culicoides exposure, whether a primary sensitizing Culicoides allergen can be identified and if an increase of allergen-specific immunoglobulin (Ig)E or IgG subclasses precedes clinical signs of IBH. ANIMALS: Thirty two horses imported from Iceland to Europe; 16 developed IBH and 16 remained healthy. METHODS: Determination of IgE and IgG subclasses against recombinant (r)-Culicoides allergens and Culicoides extract in sera taken before first exposure to Culicoides and yearly over a period of 3-4 years. RESULTS: Before Culicoides exposure, there were no significant differences in Culicoides-specific serum IgE levels between horse that developed IBH or remained healthy. Culicoides exposure induced an individual IgE response pattern (to a median of 4.5 r-allergens) in the IBH but not in the healthy end-point group. The increase in serum IgE levels to Culicoides r-allergens was concurrent with the initial onset of clinical signs of IBH. IBH-affected horses displayed significantly higher allergen-specific IgG1 and IgG5 levels than healthy controls. Recombinant Culicoides obsoletus 1 (Cul o1) and Cul o3-specific IgG5 was significantly higher in the IBH compared to the healthy end-point group, before clinical signs of IBH. CONCLUSION/CLINICAL RELEVANCE: Allergen-specific serum IgE cannot be used as predictor for IBH, whereas allergen-specific IgG5 levels may have a predictive value. SN - 1365-3164 UR - https://www.unboundmedicine.com/medline/citation/28980353/Longitudinal_analysis_of_allergen_specific_IgE_and_IgG_subclasses_as_potential_predictors_of_insect_bite_hypersensitivity_following_first_exposure_to_Culicoides_in_Icelandic_horses_ L2 - https://doi.org/10.1111/vde.12493 DB - PRIME DP - Unbound Medicine ER -