Tags

Type your tag names separated by a space and hit enter

Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study.
J Alzheimers Dis 2017; 60(3):1119-1128JA

Abstract

BACKGROUND

Performance on episodic, semantic, and working memory tests is impaired in Alzheimer's disease (AD)-type dementia, but it is unclear which type of memory test is most strongly associated with early AD biomarkers in cerebrospinal fluid (CSF), and most useful for monitoring disease progression.

OBJECTIVE

To examine the association between amyloid-β 1-42 (Aβ42) and tau in CSF with performance on different memory domains at baseline, and how these CSF markers are related with memory decline.

METHODS

We included 263 individuals with normal cognition, mild cognitive impairment, AD-type dementia, and non-AD dementia from the European EDAR study. Assessment included CSF Aβ42 and t-tau analyses with INNO-BIA AlzBio3 Luminex assay, the CERAD wordlist learning and delayed recall, animal fluency test, and the CANTAB Paired Associates Learning (PAL) and Spatial Working Memory tasks. Follow-up assessments were performed within 3 years after baseline.

RESULTS

At baseline, decreased CSF Aβ42 correlated most strongly with the PAL total errors adjusted and the wordlist delayed recall and increased CSF t-tau with the wordlist delayed recall. Over time, decreased CSF Aβ42 was associated with decline on the wordlist learning, whereas increased CSF t-tau were associated with decline in scores on the wordlist learning, wordlist delayed recall, and animal fluency. Associations were independent of baseline diagnosis.

CONCLUSION

Tests assessing episodic verbal and visuospatial memory are most useful for detection of AD pathology. Tests for episodic verbal memory and semantic memory are most useful for tracking memory decline.

Authors+Show Affiliations

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, The Netherlands.Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, The Netherlands.Department of Psychiatry, University of Cambridge, UK. School of Psychological Sciences, Monash University, Melbourne, Australia.Aristotle University of Thessaloniki, Thessaloniki, Greece.Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty of Mannheim, Heidelberg University, Germany.University Hospital Leuven, Leuven, Belgium.Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.Cambridge Cognition, Cambridge, UK.ADx NeuroSciences, Gent, Belgium.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands. Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

28984585

Citation

Reijs, Babette L R., et al. "Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: a Longitudinal Cohort Study." Journal of Alzheimer's Disease : JAD, vol. 60, no. 3, 2017, pp. 1119-1128.
Reijs BLR, Ramakers IHGB, Köhler S, et al. Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study. J Alzheimers Dis. 2017;60(3):1119-1128.
Reijs, B. L. R., Ramakers, I. H. G. B., Köhler, S., Teunissen, C. E., Koel-Simmelink, M., Nathan, P. J., ... Visser, P. J. (2017). Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study. Journal of Alzheimer's Disease : JAD, 60(3), pp. 1119-1128. doi:10.3233/JAD-160766.
Reijs BLR, et al. Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: a Longitudinal Cohort Study. J Alzheimers Dis. 2017;60(3):1119-1128. PubMed PMID: 28984585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study. AU - Reijs,Babette L R, AU - Ramakers,Inez H G B, AU - Köhler,Sebastian, AU - Teunissen,Charlotte E, AU - Koel-Simmelink,Marleen, AU - Nathan,Pradeep J, AU - Tsolaki,Magda, AU - Wahlund,Lars-Olof, AU - Waldemar,Gunhild, AU - Hausner,Lucrezia, AU - Vandenberghe,Rik, AU - Johannsen,Peter, AU - Blackwell,Andrew, AU - Vanderstichele,Hugo, AU - Verhey,Frans, AU - Visser,Pieter Jelle, PY - 2017/10/7/entrez PY - 2017/10/7/pubmed PY - 2018/5/31/medline KW - Alzheimer’s disease KW - amyloid-β KW - biomarkers KW - cerebrospinal fluid KW - episodic memory KW - spatial memory KW - working memory SP - 1119 EP - 1128 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 60 IS - 3 N2 - BACKGROUND: Performance on episodic, semantic, and working memory tests is impaired in Alzheimer's disease (AD)-type dementia, but it is unclear which type of memory test is most strongly associated with early AD biomarkers in cerebrospinal fluid (CSF), and most useful for monitoring disease progression. OBJECTIVE: To examine the association between amyloid-β 1-42 (Aβ42) and tau in CSF with performance on different memory domains at baseline, and how these CSF markers are related with memory decline. METHODS: We included 263 individuals with normal cognition, mild cognitive impairment, AD-type dementia, and non-AD dementia from the European EDAR study. Assessment included CSF Aβ42 and t-tau analyses with INNO-BIA AlzBio3 Luminex assay, the CERAD wordlist learning and delayed recall, animal fluency test, and the CANTAB Paired Associates Learning (PAL) and Spatial Working Memory tasks. Follow-up assessments were performed within 3 years after baseline. RESULTS: At baseline, decreased CSF Aβ42 correlated most strongly with the PAL total errors adjusted and the wordlist delayed recall and increased CSF t-tau with the wordlist delayed recall. Over time, decreased CSF Aβ42 was associated with decline on the wordlist learning, whereas increased CSF t-tau were associated with decline in scores on the wordlist learning, wordlist delayed recall, and animal fluency. Associations were independent of baseline diagnosis. CONCLUSION: Tests assessing episodic verbal and visuospatial memory are most useful for detection of AD pathology. Tests for episodic verbal memory and semantic memory are most useful for tracking memory decline. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/28984585/Memory_Correlates_of_Alzheimer's_Disease_Cerebrospinal_Fluid_Markers:_A_Longitudinal_Cohort_Study_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-160766 DB - PRIME DP - Unbound Medicine ER -