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The Role of Vitamin D in Disease Progression in Early Parkinson's Disease.
J Parkinsons Dis 2017; 7(4):669-675JP

Abstract

BACKGROUND

Previous cross-sectional studies have shown that Parkinson's disease (PD) patients have lower serum 25-hydroxy vitamin D (25(OH)D) concentrations than controls. Vitamin D deficiency was associated with increased disease severity and cognitive impairment in prevalent PD patients.

OBJECTIVE

The aim of the study was to determine 25(OH)D in newly diagnosed PD and age-matched controls and to assess if there was an association with clinical outcomes (disease severity, cognition and falls) over the 36-month follow up period.

METHODS

A prospective observational study of newly diagnosed PD patients in the North East of England with age-matched controls (PD, n = 145; control, n = 94). Serum 25(OH)D was assessed at baseline and 18 months. Participants underwent clinical assessment at baseline, 18 and 36 months. One hundred and ten participants with PD also took part in a prospective falls study.

RESULTS

Mean serum 25(OH)D concentrations were lower in PD than control participants at baseline (44.1±21.7 vs. 52.2±22.1 nmol/L, p < 0.05) and 18 months (44.2±23.6 vs. 55.7±28.8 nmol/L, p < 0.05). Baseline serum 25(OH)D concentration, age, motor score and dosage of dopaminergic medication were significant predictors of variance of motor severity at 36 months ((ΔR2 = 0.039, F = 6.6, p < 0.01). Serum 25(OH)D was not associated with cognition or falls during the follow up period.

CONCLUSIONS

Patients with incident PD had significantly lower serum 25(OH)D concentrations than age-matched controls, which may have implications in terms of bone health and fracture risk. There was a small but significant association between vitamin D status at baseline and disease motor severity at 36 months.

Authors+Show Affiliations

Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.Bone Clinic, Freeman Hospital, Freeman Road, Newcastle upon Tyne, UK.Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.Industrial Statistics Research Unit, Herschel Building, Newcastle University, Newcastle upon Tyne, UK.Department of Geriatric Medicine, University of Edinburgh, Edinburgh, UK.School of Medicine and Menzies Health Institute Queensland, Griffith University, QLD, Australia.Department of Medicine, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich Research Park, Norwich, UK. MRC Human Nutrition Research, Cambridge, UK.Institute of Neuroscience, Newcastle University, Clinical Ageing Research Unit, Campus for Ageing and Vitality, UK.Institute of Neuroscience, The Medical School, Newcastle University, UK.Institute of Neuroscience, The Medical School, Newcastle University, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28984616

Citation

Sleeman, Isobel, et al. "The Role of Vitamin D in Disease Progression in Early Parkinson's Disease." Journal of Parkinson's Disease, vol. 7, no. 4, 2017, pp. 669-675.
Sleeman I, Aspray T, Lawson R, et al. The Role of Vitamin D in Disease Progression in Early Parkinson's Disease. J Parkinsons Dis. 2017;7(4):669-675.
Sleeman, I., Aspray, T., Lawson, R., Coleman, S., Duncan, G., Khoo, T. K., ... Yarnall, A. (2017). The Role of Vitamin D in Disease Progression in Early Parkinson's Disease. Journal of Parkinson's Disease, 7(4), pp. 669-675. doi:10.3233/JPD-171122.
Sleeman I, et al. The Role of Vitamin D in Disease Progression in Early Parkinson's Disease. J Parkinsons Dis. 2017;7(4):669-675. PubMed PMID: 28984616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Vitamin D in Disease Progression in Early Parkinson's Disease. AU - Sleeman,Isobel, AU - Aspray,Terry, AU - Lawson,Rachael, AU - Coleman,Shirley, AU - Duncan,Gordon, AU - Khoo,Tien K, AU - Schoenmakers,Inez, AU - Rochester,Lynn, AU - Burn,David, AU - Yarnall,Alison, PY - 2017/10/7/pubmed PY - 2018/6/16/medline PY - 2017/10/7/entrez KW - 25-hydroxy vitamin D KW - Balance KW - Parkinson’s disease KW - cognition KW - disease progression KW - fall KW - vitamin D SP - 669 EP - 675 JF - Journal of Parkinson's disease JO - J Parkinsons Dis VL - 7 IS - 4 N2 - BACKGROUND: Previous cross-sectional studies have shown that Parkinson's disease (PD) patients have lower serum 25-hydroxy vitamin D (25(OH)D) concentrations than controls. Vitamin D deficiency was associated with increased disease severity and cognitive impairment in prevalent PD patients. OBJECTIVE: The aim of the study was to determine 25(OH)D in newly diagnosed PD and age-matched controls and to assess if there was an association with clinical outcomes (disease severity, cognition and falls) over the 36-month follow up period. METHODS: A prospective observational study of newly diagnosed PD patients in the North East of England with age-matched controls (PD, n = 145; control, n = 94). Serum 25(OH)D was assessed at baseline and 18 months. Participants underwent clinical assessment at baseline, 18 and 36 months. One hundred and ten participants with PD also took part in a prospective falls study. RESULTS: Mean serum 25(OH)D concentrations were lower in PD than control participants at baseline (44.1±21.7 vs. 52.2±22.1 nmol/L, p < 0.05) and 18 months (44.2±23.6 vs. 55.7±28.8 nmol/L, p < 0.05). Baseline serum 25(OH)D concentration, age, motor score and dosage of dopaminergic medication were significant predictors of variance of motor severity at 36 months ((ΔR2 = 0.039, F = 6.6, p < 0.01). Serum 25(OH)D was not associated with cognition or falls during the follow up period. CONCLUSIONS: Patients with incident PD had significantly lower serum 25(OH)D concentrations than age-matched controls, which may have implications in terms of bone health and fracture risk. There was a small but significant association between vitamin D status at baseline and disease motor severity at 36 months. SN - 1877-718X UR - https://www.unboundmedicine.com/medline/citation/28984616/The_Role_of_Vitamin_D_in_Disease_Progression_in_Early_Parkinson's_Disease_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JPD-171122 DB - PRIME DP - Unbound Medicine ER -