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Drug discrimination studies with MDMA and amphetamine.
Psychopharmacology (Berl). 1988; 95(1):71-6.P

Abstract

The term entactogen has recently been introduced to describe a new pharmacological class of compounds best represented by 3,4-methylenedioxymethamphetamine, MDMA, and its alpha-ethyl homologue MBDB. The present study was designed to test the similarities of the discriminative stimulus properties produced by MDMA and MBDB, as well as to elaborate further the distinction between entactogens, hallucinogens and stimulants. Two groups of rats were trained to discriminate saline from either racemic MDMA hydrochloride (1.75 mg/kg) or S-(+)-amphetamine sulfate (1.0 mg/kg) in a two-lever drug discrimination task. The (+/-)-MDMA cue completely generalized to S-(+)-MDMA, S-(+)-amphetamine, (+/-)-MDA, S-(+)-MBDB, (+/-)-MBDB, R-(-)-MDMA, and R-(-)-MBDB, but not to LSD or DOM. The S-(+)-amphetamine cue generalized to (+/-)-methamphetamine, but not to racemic MDMA or MBDB, nor to their optical isomers. The S-(+)-isomers of both MDMA and MBDB were more potent than the R-(-)-isomers. The results indicate that MDMA and MBDB may share a component of their discriminative stimulus properties which is different from both stimulants and hallucinogens. Although MDA and MDMA have been shown to be amphetamine-like, the lack of stimulant effects for MBDB suggests that amphetamine-like stimulant activity is not necessary for a compound to share discriminative stimulus properties with MDMA.

Authors+Show Affiliations

Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2898791

Citation

Oberlender, R, and D E. Nichols. "Drug Discrimination Studies With MDMA and Amphetamine." Psychopharmacology, vol. 95, no. 1, 1988, pp. 71-6.
Oberlender R, Nichols DE. Drug discrimination studies with MDMA and amphetamine. Psychopharmacology (Berl). 1988;95(1):71-6.
Oberlender, R., & Nichols, D. E. (1988). Drug discrimination studies with MDMA and amphetamine. Psychopharmacology, 95(1), 71-6.
Oberlender R, Nichols DE. Drug Discrimination Studies With MDMA and Amphetamine. Psychopharmacology (Berl). 1988;95(1):71-6. PubMed PMID: 2898791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug discrimination studies with MDMA and amphetamine. AU - Oberlender,R, AU - Nichols,D E, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 71 EP - 6 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 95 IS - 1 N2 - The term entactogen has recently been introduced to describe a new pharmacological class of compounds best represented by 3,4-methylenedioxymethamphetamine, MDMA, and its alpha-ethyl homologue MBDB. The present study was designed to test the similarities of the discriminative stimulus properties produced by MDMA and MBDB, as well as to elaborate further the distinction between entactogens, hallucinogens and stimulants. Two groups of rats were trained to discriminate saline from either racemic MDMA hydrochloride (1.75 mg/kg) or S-(+)-amphetamine sulfate (1.0 mg/kg) in a two-lever drug discrimination task. The (+/-)-MDMA cue completely generalized to S-(+)-MDMA, S-(+)-amphetamine, (+/-)-MDA, S-(+)-MBDB, (+/-)-MBDB, R-(-)-MDMA, and R-(-)-MBDB, but not to LSD or DOM. The S-(+)-amphetamine cue generalized to (+/-)-methamphetamine, but not to racemic MDMA or MBDB, nor to their optical isomers. The S-(+)-isomers of both MDMA and MBDB were more potent than the R-(-)-isomers. The results indicate that MDMA and MBDB may share a component of their discriminative stimulus properties which is different from both stimulants and hallucinogens. Although MDA and MDMA have been shown to be amphetamine-like, the lack of stimulant effects for MBDB suggests that amphetamine-like stimulant activity is not necessary for a compound to share discriminative stimulus properties with MDMA. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/2898791/Drug_discrimination_studies_with_MDMA_and_amphetamine_ DB - PRIME DP - Unbound Medicine ER -