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The oral microbiota in colorectal cancer is distinctive and predictive.
Gut. 2018 08; 67(8):1454-1463.Gut

Abstract

BACKGROUND AND AIMS

Microbiota alterations are linked with colorectal cancer (CRC) and notably higher abundance of putative oral bacteria on colonic tumours. However, it is not known if colonic mucosa-associated taxa are indeed orally derived, if such cases are a distinct subset of patients or if the oral microbiome is generally suitable for screening for CRC.

METHODS

We profiled the microbiota in oral swabs, colonic mucosae and stool from individuals with CRC (99 subjects), colorectal polyps (32) or controls (103).

RESULTS

Several oral taxa were differentially abundant in CRC compared with controls, for example, Streptococcus and Prevotellas pp. A classification model of oral swab microbiota distinguished individuals with CRC or polyps from controls (sensitivity: 53% (CRC)/67% (polyps); specificity: 96%). Combining the data from faecal microbiota and oral swab microbiota increased the sensitivity of this model to 76% (CRC)/88% (polyps). We detected similar bacterial networks in colonic microbiota and oral microbiota datasets comprising putative oral biofilm forming bacteria. While these taxa were more abundant in CRC, core networks between pathogenic, CRC-associated oral bacteria such as Peptostreptococcus, Parvimonas and Fusobacterium were also detected in healthy controls. High abundance of Lachnospiraceae was negatively associated with the colonisation of colonic tissue with oral-like bacterial networks suggesting a protective role for certain microbiota types against CRC, possibly by conferring colonisation resistance to CRC-associated oral taxa and possibly mediated through habitual diet.

CONCLUSION

The heterogeneity of CRC may relate to microbiota types that either predispose or provide resistance to the disease, and profiling the oral microbiome may offer an alternative screen for detecting CRC.

Authors+Show Affiliations

APC Microbiome Institue, University College Cork, National University of Ireland, Cork, Ireland. Schools of Microbiology, University College Cork, National University of Ireland, Cork, Ireland.APC Microbiome Institue, University College Cork, National University of Ireland, Cork, Ireland.APC Microbiome Institue, University College Cork, National University of Ireland, Cork, Ireland. Schools of Microbiology, University College Cork, National University of Ireland, Cork, Ireland.4D Pharma Cork Ltd, Cork, Ireland.4D Pharma Cork Ltd, Cork, Ireland.APC Microbiome Institue, University College Cork, National University of Ireland, Cork, Ireland. Schools of Microbiology, University College Cork, National University of Ireland, Cork, Ireland.Schools of Microbiology, University College Cork, National University of Ireland, Cork, Ireland. Department of Dentistry, University College Cork, National University of Ireland, Cork, Ireland.Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland.APC Microbiome Institue, University College Cork, National University of Ireland, Cork, Ireland. Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland.APC Microbiome Institue, University College Cork, National University of Ireland, Cork, Ireland. Schools of Microbiology, University College Cork, National University of Ireland, Cork, Ireland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28988196

Citation

Flemer, Burkhardt, et al. "The Oral Microbiota in Colorectal Cancer Is Distinctive and Predictive." Gut, vol. 67, no. 8, 2018, pp. 1454-1463.
Flemer B, Warren RD, Barrett MP, et al. The oral microbiota in colorectal cancer is distinctive and predictive. Gut. 2018;67(8):1454-1463.
Flemer, B., Warren, R. D., Barrett, M. P., Cisek, K., Das, A., Jeffery, I. B., Hurley, E., O'Riordain, M., Shanahan, F., & O'Toole, P. W. (2018). The oral microbiota in colorectal cancer is distinctive and predictive. Gut, 67(8), 1454-1463. https://doi.org/10.1136/gutjnl-2017-314814
Flemer B, et al. The Oral Microbiota in Colorectal Cancer Is Distinctive and Predictive. Gut. 2018;67(8):1454-1463. PubMed PMID: 28988196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The oral microbiota in colorectal cancer is distinctive and predictive. AU - Flemer,Burkhardt, AU - Warren,Ryan D, AU - Barrett,Maurice P, AU - Cisek,Katryna, AU - Das,Anubhav, AU - Jeffery,Ian B, AU - Hurley,Eimear, AU - O'Riordain,Micheal, AU - Shanahan,Fergus, AU - O'Toole,Paul W, Y1 - 2017/10/07/ PY - 2017/07/12/received PY - 2017/09/20/revised PY - 2017/09/21/accepted PY - 2017/10/11/pubmed PY - 2018/7/24/medline PY - 2017/10/9/entrez KW - colonic bacteria KW - colorectal cancer KW - colorectal cancer screening KW - diet KW - tumour markers SP - 1454 EP - 1463 JF - Gut JO - Gut VL - 67 IS - 8 N2 - BACKGROUND AND AIMS: Microbiota alterations are linked with colorectal cancer (CRC) and notably higher abundance of putative oral bacteria on colonic tumours. However, it is not known if colonic mucosa-associated taxa are indeed orally derived, if such cases are a distinct subset of patients or if the oral microbiome is generally suitable for screening for CRC. METHODS: We profiled the microbiota in oral swabs, colonic mucosae and stool from individuals with CRC (99 subjects), colorectal polyps (32) or controls (103). RESULTS: Several oral taxa were differentially abundant in CRC compared with controls, for example, Streptococcus and Prevotellas pp. A classification model of oral swab microbiota distinguished individuals with CRC or polyps from controls (sensitivity: 53% (CRC)/67% (polyps); specificity: 96%). Combining the data from faecal microbiota and oral swab microbiota increased the sensitivity of this model to 76% (CRC)/88% (polyps). We detected similar bacterial networks in colonic microbiota and oral microbiota datasets comprising putative oral biofilm forming bacteria. While these taxa were more abundant in CRC, core networks between pathogenic, CRC-associated oral bacteria such as Peptostreptococcus, Parvimonas and Fusobacterium were also detected in healthy controls. High abundance of Lachnospiraceae was negatively associated with the colonisation of colonic tissue with oral-like bacterial networks suggesting a protective role for certain microbiota types against CRC, possibly by conferring colonisation resistance to CRC-associated oral taxa and possibly mediated through habitual diet. CONCLUSION: The heterogeneity of CRC may relate to microbiota types that either predispose or provide resistance to the disease, and profiling the oral microbiome may offer an alternative screen for detecting CRC. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/28988196/The_oral_microbiota_in_colorectal_cancer_is_distinctive_and_predictive_ L2 - http://gut.bmj.com/lookup/pmidlookup?view=long&pmid=28988196 DB - PRIME DP - Unbound Medicine ER -