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Serum gamma-glutamyltransferase is inversely associated with dietary total and coffee-derived polyphenol intakes in apparently healthy Japanese men.
Eur J Nutr 2018; 57(8):2819-2826EJ

Abstract

PURPOSE

Serum γ-glutamyltransferase (GGT) has been proposed as a marker of oxidative stress. Here, we examined the association between serum GGT and the dietary intake of polyphenols, which have antioxidant properties.

METHODS

A cross-sectional survey including 7960 apparently healthy Japanese men (aged 22-86 years) who participated in health checkups was conducted in Shizuoka, Japan. We analyzed these subjects' clinical serum parameters and lifestyle factors, including dietary polyphenol intake, which was evaluated by a self-administered questionnaire and by matching the subjects' food consumption data with our original polyphenol content database.

RESULTS

The average intake of polyphenols was 1157 ± 471 mg/day, and green tea was the largest source of polyphenols at 40%, followed by coffee at 36%. Dividing the population according to quintiles of total polyphenol intake, the difference in polyphenol intake from coffee between the groups was much greater than the difference in polyphenol intake from green tea. The analysis of the association between polyphenol intake and biological parameters showed a significant negative association between polyphenol intake and the levels of systolic and diastolic blood pressure (SBP and DBP), GGT, and alanine aminotransferase (ALT) after adjusting for age, smoking habit, energy intake and alcohol intake. The GGT levels were inversely associated with the polyphenol intake from coffee, but not with that from green tea. Multivariable linear regression analyses demonstrated that the subjects' GGT levels were negatively and independently associated with their polyphenol intake.

CONCLUSIONS

The intake of total polyphenol including coffee as a major contributor is inversely associated with the serum GGT concentration in Japanese males.

Authors+Show Affiliations

School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. Endowed Research Department "Food for Health", Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo, 112-8610, Japan.Endowed Research Department "Food for Health", Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo, 112-8610, Japan.Endowed Research Department "Food for Health", Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo, 112-8610, Japan. Institute of Life Innovations Studies, Toyo University, 1-1-1 Izumino, Itakura-machi, Ora-gun, Gunma, 374-0193, Japan.SBS Shizuoka Health Promotion Center, 3-1-1 Toro, Suruga-ku, Shizuoka, 422-8033, Japan.School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. gouda@u-shizuoka-ken.ac.jp.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28988315

Citation

Taguchi, Chie, et al. "Serum Gamma-glutamyltransferase Is Inversely Associated With Dietary Total and Coffee-derived Polyphenol Intakes in Apparently Healthy Japanese Men." European Journal of Nutrition, vol. 57, no. 8, 2018, pp. 2819-2826.
Taguchi C, Kishimoto Y, Kondo K, et al. Serum gamma-glutamyltransferase is inversely associated with dietary total and coffee-derived polyphenol intakes in apparently healthy Japanese men. Eur J Nutr. 2018;57(8):2819-2826.
Taguchi, C., Kishimoto, Y., Kondo, K., Tohyama, K., & Goda, T. (2018). Serum gamma-glutamyltransferase is inversely associated with dietary total and coffee-derived polyphenol intakes in apparently healthy Japanese men. European Journal of Nutrition, 57(8), pp. 2819-2826. doi:10.1007/s00394-017-1549-1.
Taguchi C, et al. Serum Gamma-glutamyltransferase Is Inversely Associated With Dietary Total and Coffee-derived Polyphenol Intakes in Apparently Healthy Japanese Men. Eur J Nutr. 2018;57(8):2819-2826. PubMed PMID: 28988315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum gamma-glutamyltransferase is inversely associated with dietary total and coffee-derived polyphenol intakes in apparently healthy Japanese men. AU - Taguchi,Chie, AU - Kishimoto,Yoshimi, AU - Kondo,Kazuo, AU - Tohyama,Kazushige, AU - Goda,Toshinao, Y1 - 2017/10/07/ PY - 2017/02/17/received PY - 2017/09/28/accepted PY - 2017/10/11/pubmed PY - 2019/4/26/medline PY - 2017/10/9/entrez KW - Coffee KW - GGT KW - Gamma-glutamyltransferase KW - Green tea KW - Polyphenol intake SP - 2819 EP - 2826 JF - European journal of nutrition JO - Eur J Nutr VL - 57 IS - 8 N2 - PURPOSE: Serum γ-glutamyltransferase (GGT) has been proposed as a marker of oxidative stress. Here, we examined the association between serum GGT and the dietary intake of polyphenols, which have antioxidant properties. METHODS: A cross-sectional survey including 7960 apparently healthy Japanese men (aged 22-86 years) who participated in health checkups was conducted in Shizuoka, Japan. We analyzed these subjects' clinical serum parameters and lifestyle factors, including dietary polyphenol intake, which was evaluated by a self-administered questionnaire and by matching the subjects' food consumption data with our original polyphenol content database. RESULTS: The average intake of polyphenols was 1157 ± 471 mg/day, and green tea was the largest source of polyphenols at 40%, followed by coffee at 36%. Dividing the population according to quintiles of total polyphenol intake, the difference in polyphenol intake from coffee between the groups was much greater than the difference in polyphenol intake from green tea. The analysis of the association between polyphenol intake and biological parameters showed a significant negative association between polyphenol intake and the levels of systolic and diastolic blood pressure (SBP and DBP), GGT, and alanine aminotransferase (ALT) after adjusting for age, smoking habit, energy intake and alcohol intake. The GGT levels were inversely associated with the polyphenol intake from coffee, but not with that from green tea. Multivariable linear regression analyses demonstrated that the subjects' GGT levels were negatively and independently associated with their polyphenol intake. CONCLUSIONS: The intake of total polyphenol including coffee as a major contributor is inversely associated with the serum GGT concentration in Japanese males. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/28988315/Serum_gamma_glutamyltransferase_is_inversely_associated_with_dietary_total_and_coffee_derived_polyphenol_intakes_in_apparently_healthy_Japanese_men_ L2 - https://dx.doi.org/10.1007/s00394-017-1549-1 DB - PRIME DP - Unbound Medicine ER -