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PTPN22 1858C > T polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update.
Autoimmunity. 2017 Nov; 50(7):428-434.A

Abstract

Studies performed in the past years showed PTNP22 1858 C > T (rs2476601) polymorphism as associated with systemic lupus erythematosus susceptibility, although conflicting findings are still found. In this context, a powerful statistical study, such as meta-analysis, is necessary to establish a consensus. The aim of this study was to evaluate association studies between the PTPN22 1858 C > T polymorphism and SLE by a meta-analysis update, including three recently published studies in the last three years. A total of 3868 SLE patients and 7458 healthy individuals were considered herein, enclosing 19 studies from Asian, American, European and Latin ethnic groups. Odds ratio (OR) was performed for allelic, dominant and recessive genetic models. Statistically significant association was found between the PTPN22 1858 C > T polymorphism and susceptibility to SLE in all inheritance models. Allelic genetic model data (OR = 1.54, 95% confidence interval (CI) = 1.38-1.72, p value=.000) shows that T allele confers increased SLE susceptibility. As well as recessive genetic model (OR = 2.04, 95% CI = 1.09-3.82, p value = .030) for T/T genotype. Instead, dominant genetic model shows that C/C genotype confers lower susceptibility for SLE development (OR = 0.62, 95% CI = 0.54-0.72, p value = .000). In addition, we provided an ethnicity-derived meta-analysis. The results showed association in Caucasian (OR = 1.47, p value = .000) and Latin (OR = 2.41, p value = .000) ethnic groups. However, rs2476601 polymorphism is not associated nor in Asian (OR= 1.31; p value = .54) and African (OR = 2.04; p value=.22) populations. In conclusion, present meta-analysis update confirms that T allele and T/T genotype in PTPN22 1858 C > T polymorphism confers SLE susceptibility, particular in Caucasian and Latin groups, suggesting PTPN22 1858 C > T as a potential genetic marker in SLE susceptibility.

Authors+Show Affiliations

a Laboratory of Immunopathology Keizo Asami (LIKA) , Federal University of Pernambuco , Recife , Brazil.a Laboratory of Immunopathology Keizo Asami (LIKA) , Federal University of Pernambuco , Recife , Brazil. b Department of Genetics , Federal University of Pernambuco , Recife , Brazil.a Laboratory of Immunopathology Keizo Asami (LIKA) , Federal University of Pernambuco , Recife , Brazil. b Department of Genetics , Federal University of Pernambuco , Recife , Brazil.a Laboratory of Immunopathology Keizo Asami (LIKA) , Federal University of Pernambuco , Recife , Brazil. b Department of Genetics , Federal University of Pernambuco , Recife , Brazil.a Laboratory of Immunopathology Keizo Asami (LIKA) , Federal University of Pernambuco , Recife , Brazil. b Department of Genetics , Federal University of Pernambuco , Recife , Brazil.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

28990435

Citation

de Lima, Suelen Cristina, et al. "PTPN22 1858C > T Polymorphism and Susceptibility to Systemic Lupus Erythematosus: a Meta-analysis Update." Autoimmunity, vol. 50, no. 7, 2017, pp. 428-434.
de Lima SC, Adelino JE, Crovella S, et al. PTPN22 1858C > T polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update. Autoimmunity. 2017;50(7):428-434.
de Lima, S. C., Adelino, J. E., Crovella, S., de Azevedo Silva, J., & Sandrin-Garcia, P. (2017). PTPN22 1858C > T polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update. Autoimmunity, 50(7), 428-434. https://doi.org/10.1080/08916934.2017.1385774
de Lima SC, et al. PTPN22 1858C > T Polymorphism and Susceptibility to Systemic Lupus Erythematosus: a Meta-analysis Update. Autoimmunity. 2017;50(7):428-434. PubMed PMID: 28990435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PTPN22 1858C > T polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update. AU - de Lima,Suelen Cristina, AU - Adelino,José Eduardo, AU - Crovella,Sergio, AU - de Azevedo Silva,Jaqueline, AU - Sandrin-Garcia,Paula, Y1 - 2017/10/08/ PY - 2017/10/11/pubmed PY - 2018/6/7/medline PY - 2017/10/10/entrez KW - 1858C > T KW - Meta-analysis KW - SLE KW - polymorphism SP - 428 EP - 434 JF - Autoimmunity JO - Autoimmunity VL - 50 IS - 7 N2 - Studies performed in the past years showed PTNP22 1858 C > T (rs2476601) polymorphism as associated with systemic lupus erythematosus susceptibility, although conflicting findings are still found. In this context, a powerful statistical study, such as meta-analysis, is necessary to establish a consensus. The aim of this study was to evaluate association studies between the PTPN22 1858 C > T polymorphism and SLE by a meta-analysis update, including three recently published studies in the last three years. A total of 3868 SLE patients and 7458 healthy individuals were considered herein, enclosing 19 studies from Asian, American, European and Latin ethnic groups. Odds ratio (OR) was performed for allelic, dominant and recessive genetic models. Statistically significant association was found between the PTPN22 1858 C > T polymorphism and susceptibility to SLE in all inheritance models. Allelic genetic model data (OR = 1.54, 95% confidence interval (CI) = 1.38-1.72, p value=.000) shows that T allele confers increased SLE susceptibility. As well as recessive genetic model (OR = 2.04, 95% CI = 1.09-3.82, p value = .030) for T/T genotype. Instead, dominant genetic model shows that C/C genotype confers lower susceptibility for SLE development (OR = 0.62, 95% CI = 0.54-0.72, p value = .000). In addition, we provided an ethnicity-derived meta-analysis. The results showed association in Caucasian (OR = 1.47, p value = .000) and Latin (OR = 2.41, p value = .000) ethnic groups. However, rs2476601 polymorphism is not associated nor in Asian (OR= 1.31; p value = .54) and African (OR = 2.04; p value=.22) populations. In conclusion, present meta-analysis update confirms that T allele and T/T genotype in PTPN22 1858 C > T polymorphism confers SLE susceptibility, particular in Caucasian and Latin groups, suggesting PTPN22 1858 C > T as a potential genetic marker in SLE susceptibility. SN - 1607-842X UR - https://www.unboundmedicine.com/medline/citation/28990435/PTPN22_1858C_>_T_polymorphism_and_susceptibility_to_systemic_lupus_erythematosus:_a_meta_analysis_update_ L2 - http://www.tandfonline.com/doi/full/10.1080/08916934.2017.1385774 DB - PRIME DP - Unbound Medicine ER -