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Protective Effects of the Caffeine Against Neurodegenerative Diseases.
Curr Med Chem. 2019; 26(27):5137-5151.CM

Abstract

BACKGROUND

Recent studies and increased interest of the scientific community helped to clarify the neurological health property of caffeine, one of the pharmacologically active substances most consumed in the world.

METHODS

This article is a review search to provide an overview on the current state of understanding neurobiochemical impact of caffeine, focusing on the ability of the drug to effectively counteract several neurodegenerative disorders such as Alzheimer's, Parkinson's, Huntington's diseases, Multiple sclerosis and Amyotrophic lateral sclerosis.

RESULTS

Data collection shown in this review provide a significant therapeutic and prophylactic potentiality of caffeine which acts on human brain through several pathways because of its antioxidant activity combined with multiple molecular targets. However, the need to adjust the CF dosage to individuals, because some people are more sensitive to drugs than others, may constituted a limit to the CF effectiveness.

CONCLUSION

What emerges from the complex of clinical and epidemiological studies is a significant CF potential impact against all neurological disorders. Although, further studies are needed to fully elucidate the several mechanisms of drug action which in part are still elusive.

Authors+Show Affiliations

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V. le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28990513

Citation

Tellone, Ester, et al. "Protective Effects of the Caffeine Against Neurodegenerative Diseases." Current Medicinal Chemistry, vol. 26, no. 27, 2019, pp. 5137-5151.
Tellone E, Galtieri A, Russo A, et al. Protective Effects of the Caffeine Against Neurodegenerative Diseases. Curr Med Chem. 2019;26(27):5137-5151.
Tellone, E., Galtieri, A., Russo, A., & Ficarra, S. (2019). Protective Effects of the Caffeine Against Neurodegenerative Diseases. Current Medicinal Chemistry, 26(27), 5137-5151. https://doi.org/10.2174/0929867324666171009104040
Tellone E, et al. Protective Effects of the Caffeine Against Neurodegenerative Diseases. Curr Med Chem. 2019;26(27):5137-5151. PubMed PMID: 28990513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective Effects of the Caffeine Against Neurodegenerative Diseases. AU - Tellone,Ester, AU - Galtieri,Antonio, AU - Russo,Annamaria, AU - Ficarra,Silvana, PY - 2017/03/08/received PY - 2017/09/19/revised PY - 2017/09/25/accepted PY - 2017/10/11/pubmed PY - 2019/11/27/medline PY - 2017/10/10/entrez KW - ALS KW - Adenosine receptors KW - Antioxidant activity KW - Caffeine KW - Mitochondrial biogenesis KW - Neurodegeneration KW - Neuroproective effects. SP - 5137 EP - 5151 JF - Current medicinal chemistry JO - Curr Med Chem VL - 26 IS - 27 N2 - BACKGROUND: Recent studies and increased interest of the scientific community helped to clarify the neurological health property of caffeine, one of the pharmacologically active substances most consumed in the world. METHODS: This article is a review search to provide an overview on the current state of understanding neurobiochemical impact of caffeine, focusing on the ability of the drug to effectively counteract several neurodegenerative disorders such as Alzheimer's, Parkinson's, Huntington's diseases, Multiple sclerosis and Amyotrophic lateral sclerosis. RESULTS: Data collection shown in this review provide a significant therapeutic and prophylactic potentiality of caffeine which acts on human brain through several pathways because of its antioxidant activity combined with multiple molecular targets. However, the need to adjust the CF dosage to individuals, because some people are more sensitive to drugs than others, may constituted a limit to the CF effectiveness. CONCLUSION: What emerges from the complex of clinical and epidemiological studies is a significant CF potential impact against all neurological disorders. Although, further studies are needed to fully elucidate the several mechanisms of drug action which in part are still elusive. SN - 1875-533X UR - https://www.unboundmedicine.com/medline/citation/28990513/Protective_Effects_of_the_Caffeine_Against_Neurodegenerative_Diseases_ DB - PRIME DP - Unbound Medicine ER -