Tags

Type your tag names separated by a space and hit enter

Pancreatic hormone secretion in chronic pancreatitis without residual beta-cell function.
Acta Endocrinol (Copenh). 1988 Jul; 118(3):357-64.AE

Abstract

Hormonal responses (glucagon, pancreatic polypeptide and somatostatin) to iv glucagon, iv arginine, and ingestion of a mixed meal were investigated in 6 patients with insulin-dependent diabetes secondary to chronic pancreatitis without beta-cell function, in 8 Type I (insulin-dependent) diabetics without beta-cell function, and 8 healthy subjects. No significant differences were found between the two diabetic groups regarding glucagon responses to arginine and meal ingestion. In the patients with diabetes secondary to chronic pancreatitis compared with Type I diabetics and normal controls, the pancreatic polypeptide concentrations were significantly lower and somatostatin concentrations were significantly higher after glucagon, arginine and a mixed meal. Thus, pancreatic glucagon secretion was preserved in patients with insulin-dependent diabetes secondary to chronic pancreatitis, having no residual beta-cell function. These findings suggest that pancreatic glucagon deficiency is not absolute in insulin-dependent diabetes secondary to chronic pancreatitis. A high level of somatostatin may contribute to a lower blood glucose level in patients with chronic pancreatitis.

Authors+Show Affiliations

Medical Department F, Glostrup Hospital, University of Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2899369

Citation

Larsen, S, et al. "Pancreatic Hormone Secretion in Chronic Pancreatitis Without Residual Beta-cell Function." Acta Endocrinologica, vol. 118, no. 3, 1988, pp. 357-64.
Larsen S, Hilsted J, Tronier B, et al. Pancreatic hormone secretion in chronic pancreatitis without residual beta-cell function. Acta Endocrinol (Copenh). 1988;118(3):357-64.
Larsen, S., Hilsted, J., Tronier, B., & Worning, H. (1988). Pancreatic hormone secretion in chronic pancreatitis without residual beta-cell function. Acta Endocrinologica, 118(3), 357-64.
Larsen S, et al. Pancreatic Hormone Secretion in Chronic Pancreatitis Without Residual Beta-cell Function. Acta Endocrinol (Copenh). 1988;118(3):357-64. PubMed PMID: 2899369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic hormone secretion in chronic pancreatitis without residual beta-cell function. AU - Larsen,S, AU - Hilsted,J, AU - Tronier,B, AU - Worning,H, PY - 1988/7/1/pubmed PY - 1988/7/1/medline PY - 1988/7/1/entrez SP - 357 EP - 64 JF - Acta endocrinologica JO - Acta Endocrinol (Copenh) VL - 118 IS - 3 N2 - Hormonal responses (glucagon, pancreatic polypeptide and somatostatin) to iv glucagon, iv arginine, and ingestion of a mixed meal were investigated in 6 patients with insulin-dependent diabetes secondary to chronic pancreatitis without beta-cell function, in 8 Type I (insulin-dependent) diabetics without beta-cell function, and 8 healthy subjects. No significant differences were found between the two diabetic groups regarding glucagon responses to arginine and meal ingestion. In the patients with diabetes secondary to chronic pancreatitis compared with Type I diabetics and normal controls, the pancreatic polypeptide concentrations were significantly lower and somatostatin concentrations were significantly higher after glucagon, arginine and a mixed meal. Thus, pancreatic glucagon secretion was preserved in patients with insulin-dependent diabetes secondary to chronic pancreatitis, having no residual beta-cell function. These findings suggest that pancreatic glucagon deficiency is not absolute in insulin-dependent diabetes secondary to chronic pancreatitis. A high level of somatostatin may contribute to a lower blood glucose level in patients with chronic pancreatitis. SN - 0001-5598 UR - https://www.unboundmedicine.com/medline/citation/2899369/Pancreatic_hormone_secretion_in_chronic_pancreatitis_without_residual_beta_cell_function_ DB - PRIME DP - Unbound Medicine ER -