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[Research on Glycyrrhizeae Radix standard decoction].
Zhongguo Zhong Yao Za Zhi. 2017 Mar; 42(5):830-835.ZZ

Abstract

Fifteen batches of Glycyrrhizeae Radix standard decoction were prepared for determination of the content of the glycyrrhizic acid and liquiritin, then the transfer rate and the extract rate were calculated and a method was established to analyze the fingerprint by HPLC. According to the measurement of 15 batches of samples,the transfer rate of the glycyrrhizic acid and liquiritin were 59.4%-87.4% and 49.8%-78.9% with extract rate of 29.9%-38.9%. Moreover,10 common chromatographic peaks were determined based on their fingerprint by using similarity evaluation system for chromatographic fingerprint of traditional Chinese medicine (TCM)(2012A) .The similarity results of 15 batches of samples were analyzed and compared,and the results showed that the similarity was all higher than 0.9. Fifteen batches of samples,prepared by a standard method,have stable quality and the high similarity.The method displayed good precision,stability and repeatability in fingerprint analysis. Therefore,this study can provide a reference for the quality control of Glycyrrhizae Radix dispensing granules.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lin WX
Guangdong Pharmaceutical University, Guangzhou 510006, China.
Le ZY
Kangmei Pharmaceutical Research Institute Co., Ltd., Beijing 102629, China.
Che HY
Kangmei Pharmaceutical Research Institute Co., Ltd., Beijing 102629, China.
Liu YZ
Guangdong Pharmaceutical University, Guangzhou 510006, China.
Liu C
Guangdong Pharmaceutical University, Guangzhou 510006, China.
Wang H
Guangdong Pharmaceutical University, Guangzhou 510006, China.

MeSH

Chromatography, High Pressure LiquidDrugs, Chinese HerbalFlavanonesGlucosidesGlycyrrhizaGlycyrrhizic AcidPlant ExtractsPlant RootsQuality Control

Pub Type(s)

Journal Article

Language

chi

PubMed ID

28994521

Citation

Lin, Wei-Xiong, et al. "[Research On Glycyrrhizeae Radix Standard Decoction]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 42, no. 5, 2017, pp. 830-835.
Lin WX, Le ZY, Che HY, et al. [Research on Glycyrrhizeae Radix standard decoction]. Zhongguo Zhong Yao Za Zhi. 2017;42(5):830-835.
Lin, W. X., Le, Z. Y., Che, H. Y., Liu, Y. Z., Liu, C., & Wang, H. (2017). [Research on Glycyrrhizeae Radix standard decoction]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 42(5), 830-835. https://doi.org/10.19540/j.cnki.cjcmm.20161222.070
Lin WX, et al. [Research On Glycyrrhizeae Radix Standard Decoction]. Zhongguo Zhong Yao Za Zhi. 2017;42(5):830-835. PubMed PMID: 28994521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Research on Glycyrrhizeae Radix standard decoction]. AU - Lin,Wei-Xiong, AU - Le,Zhi-Yong, AU - Che,Hai-Yan, AU - Liu,Yin-Zhen, AU - Liu,Chong, AU - Wang,Hui, PY - 2016/10/21/received PY - 2017/10/11/entrez PY - 2017/10/11/pubmed PY - 2018/6/26/medline KW - Glycyrrhizae Radix KW - HPLC KW - fingerprint KW - standard decoction SP - 830 EP - 835 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 42 IS - 5 N2 - Fifteen batches of Glycyrrhizeae Radix standard decoction were prepared for determination of the content of the glycyrrhizic acid and liquiritin, then the transfer rate and the extract rate were calculated and a method was established to analyze the fingerprint by HPLC. According to the measurement of 15 batches of samples,the transfer rate of the glycyrrhizic acid and liquiritin were 59.4%-87.4% and 49.8%-78.9% with extract rate of 29.9%-38.9%. Moreover,10 common chromatographic peaks were determined based on their fingerprint by using similarity evaluation system for chromatographic fingerprint of traditional Chinese medicine (TCM)(2012A) .The similarity results of 15 batches of samples were analyzed and compared,and the results showed that the similarity was all higher than 0.9. Fifteen batches of samples,prepared by a standard method,have stable quality and the high similarity.The method displayed good precision,stability and repeatability in fingerprint analysis. Therefore,this study can provide a reference for the quality control of Glycyrrhizae Radix dispensing granules. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/28994521/[Research_on_Glycyrrhizeae_Radix_standard_decoction]_ DB - PRIME DP - Unbound Medicine ER -