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Decrease in number of somatostatin receptors in rat brain after adrenalectomy: normalization after glucocorticoid replacement.
Endocrinology. 1988 Aug; 123(2):1147-52.E

Abstract

The effects of adrenalectomy on somatostatin (SS) concentration and specific binding in cerebral cortex, hippocampus, striatum, and hypothalamus were examined using [125I-Tyr11]SS as the binding ligand. Adrenalectomy did not affect the concentration of SS-like immunoreactivity in the brain areas studied. Nevertheless, the number of SS receptors was significantly decreased in membrane preparations from hippocampus, striatum, and hypothalamus, but not in cerebral cortex. No significant differences in the apparent binding affinity values were seen after adrenalectomy. The adrenalectomy-induced decreases in [125I-Tyr11]SS receptors were completely reversed by glucocorticoid replacement with dexamethasone. These results demonstrate that adrenalectomy modulates SS receptors in discrete brain areas, suggesting the existence of a possible relationship between corticosteroids and SS in the neuronal activity of these structures. The physiological significance of these findings remains to be clarified.

Authors+Show Affiliations

Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Alcala de Henares, Madrid, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2899501

Citation

Rodriguez, M N., et al. "Decrease in Number of Somatostatin Receptors in Rat Brain After Adrenalectomy: Normalization After Glucocorticoid Replacement." Endocrinology, vol. 123, no. 2, 1988, pp. 1147-52.
Rodriguez MN, Gomez-Pan A, Arilla E. Decrease in number of somatostatin receptors in rat brain after adrenalectomy: normalization after glucocorticoid replacement. Endocrinology. 1988;123(2):1147-52.
Rodriguez, M. N., Gomez-Pan, A., & Arilla, E. (1988). Decrease in number of somatostatin receptors in rat brain after adrenalectomy: normalization after glucocorticoid replacement. Endocrinology, 123(2), 1147-52.
Rodriguez MN, Gomez-Pan A, Arilla E. Decrease in Number of Somatostatin Receptors in Rat Brain After Adrenalectomy: Normalization After Glucocorticoid Replacement. Endocrinology. 1988;123(2):1147-52. PubMed PMID: 2899501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decrease in number of somatostatin receptors in rat brain after adrenalectomy: normalization after glucocorticoid replacement. AU - Rodriguez,M N, AU - Gomez-Pan,A, AU - Arilla,E, PY - 1988/8/1/pubmed PY - 1988/8/1/medline PY - 1988/8/1/entrez SP - 1147 EP - 52 JF - Endocrinology JO - Endocrinology VL - 123 IS - 2 N2 - The effects of adrenalectomy on somatostatin (SS) concentration and specific binding in cerebral cortex, hippocampus, striatum, and hypothalamus were examined using [125I-Tyr11]SS as the binding ligand. Adrenalectomy did not affect the concentration of SS-like immunoreactivity in the brain areas studied. Nevertheless, the number of SS receptors was significantly decreased in membrane preparations from hippocampus, striatum, and hypothalamus, but not in cerebral cortex. No significant differences in the apparent binding affinity values were seen after adrenalectomy. The adrenalectomy-induced decreases in [125I-Tyr11]SS receptors were completely reversed by glucocorticoid replacement with dexamethasone. These results demonstrate that adrenalectomy modulates SS receptors in discrete brain areas, suggesting the existence of a possible relationship between corticosteroids and SS in the neuronal activity of these structures. The physiological significance of these findings remains to be clarified. SN - 0013-7227 UR - https://www.unboundmedicine.com/medline/citation/2899501/Decrease_in_number_of_somatostatin_receptors_in_rat_brain_after_adrenalectomy:_normalization_after_glucocorticoid_replacement_ DB - PRIME DP - Unbound Medicine ER -