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Effect of a long-acting somatostatin derivative SMS 201-995 (sandostatin) on glucose homeostasis in type I diabetes mellitus.
Horm Res. 1988; 29(2-3):92-4.HR

Abstract

The infusion of natural somatostatin (SRIF) has been able to partially correct postprandial hyperglycemic reactions in insulin-dependent diabetes mellitus (IDDM). SMS 201-995 (Sandostatin) is a long-acting derivative with a growth hormone-suppressive effect 10-60 times more potent than the native peptide. The effect of SMS 201-995 (50 micrograms s.c.) on glucose control by exogenous insulin has been documented in a series of type I diabetics after stabilization of blood sugar by an artificial pancreas. Inhibition of counterregulatory mechanisms significantly diminished the postprandial hyperglycemia, and insulin requirements, both total and 2 h after meals, were markedly decreased. Also the effect of a single s.c. injection of 100 micrograms SMS 201-995 on the dawn phenomenon in a patient with poorly adjustable diabetes was investigated. The glucose escape observed during the control night was blocked by SMS 201-995. Thus, the stabilizing action of this peptide on postprandial and nocturnal hyperglycemia in unstable diabetes warrants further studies.

Authors+Show Affiliations

Servicio de Medicina Interna, Centro Ramón y Cajal, Madrid, España.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2900205

Citation

Navascues, I, et al. "Effect of a Long-acting Somatostatin Derivative SMS 201-995 (sandostatin) On Glucose Homeostasis in Type I Diabetes Mellitus." Hormone Research, vol. 29, no. 2-3, 1988, pp. 92-4.
Navascues I, Gil J, Pascau C, et al. Effect of a long-acting somatostatin derivative SMS 201-995 (sandostatin) on glucose homeostasis in type I diabetes mellitus. Horm Res. 1988;29(2-3):92-4.
Navascues, I., Gil, J., Pascau, C., Senén, D., del Pozo, E., & Serrano-Ríos, M. (1988). Effect of a long-acting somatostatin derivative SMS 201-995 (sandostatin) on glucose homeostasis in type I diabetes mellitus. Hormone Research, 29(2-3), 92-4.
Navascues I, et al. Effect of a Long-acting Somatostatin Derivative SMS 201-995 (sandostatin) On Glucose Homeostasis in Type I Diabetes Mellitus. Horm Res. 1988;29(2-3):92-4. PubMed PMID: 2900205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a long-acting somatostatin derivative SMS 201-995 (sandostatin) on glucose homeostasis in type I diabetes mellitus. AU - Navascues,I, AU - Gil,J, AU - Pascau,C, AU - Senén,D, AU - del Pozo,E, AU - Serrano-Ríos,M, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 92 EP - 4 JF - Hormone research JO - Horm Res VL - 29 IS - 2-3 N2 - The infusion of natural somatostatin (SRIF) has been able to partially correct postprandial hyperglycemic reactions in insulin-dependent diabetes mellitus (IDDM). SMS 201-995 (Sandostatin) is a long-acting derivative with a growth hormone-suppressive effect 10-60 times more potent than the native peptide. The effect of SMS 201-995 (50 micrograms s.c.) on glucose control by exogenous insulin has been documented in a series of type I diabetics after stabilization of blood sugar by an artificial pancreas. Inhibition of counterregulatory mechanisms significantly diminished the postprandial hyperglycemia, and insulin requirements, both total and 2 h after meals, were markedly decreased. Also the effect of a single s.c. injection of 100 micrograms SMS 201-995 on the dawn phenomenon in a patient with poorly adjustable diabetes was investigated. The glucose escape observed during the control night was blocked by SMS 201-995. Thus, the stabilizing action of this peptide on postprandial and nocturnal hyperglycemia in unstable diabetes warrants further studies. SN - 0301-0163 UR - https://www.unboundmedicine.com/medline/citation/2900205/Effect_of_a_long_acting_somatostatin_derivative_SMS_201_995__sandostatin__on_glucose_homeostasis_in_type_I_diabetes_mellitus_ DB - PRIME DP - Unbound Medicine ER -