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The effects of the somatostatin analogue SMS 201-995 on carbohydrate homeostasis of insulin-dependent diabetics as assessed by the artificial endocrine pancreas.
Diabetes Res Clin Pract. 1988 Jul 13; 5(2):91-8.DR

Abstract

On the basis of the inhibitory actions of the somatostatin analogue SMS 201-995 on growth hormone (GH) and glucagon (IRG) secretion we investigated its effects on carbohydrate metabolism of insulin-dependent diabetics. Six patients with no residual insulin secretion were connected to the artificial endocrine pancreas (AEP) and after the establishment of a steady state overnight they were injected either normal saline or 50 micrograms of SMS 201-995 s.c., t.i.d., or 100 micrograms of the same compound b.i.d. Insulin requirements were assessed by the AEP and compared during the 24 h and after the main meals. The inhibition of GH and IRG secretion was evaluated as well. 50 micrograms of SMS analogue t.i.d. induced a significant reduction of insulin requirement (mean +/- SEM) while no significant difference was observed between control and 100 micrograms s.c., b.i.d., nor between 50 micrograms and 100 micrograms. The curve of glucose fluctuations was smoother after 50 micrograms than after 100 micrograms and control. Postprandial IRG secretion was inhibited by both regimens of SMS after lunch and dinner. GH secretion was significantly inhibited after all meals during the days of analogue administration. SMS 201-995 analogue appears to have a remarkable antidiabetic activity as shown by the sparing of administered amount of insulin, suppression of counter-insulin hormones and smoothing of blood glucose curve. It may constitute a safe and effective adjunctive measure in the management of insulin-dependent diabetics.

Authors+Show Affiliations

Second Department of Internal Medicine-Propaedeutic, Athens University, Evangelismos Hospital, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2901329

Citation

Hadjidakis, D J., et al. "The Effects of the Somatostatin Analogue SMS 201-995 On Carbohydrate Homeostasis of Insulin-dependent Diabetics as Assessed By the Artificial Endocrine Pancreas." Diabetes Research and Clinical Practice, vol. 5, no. 2, 1988, pp. 91-8.
Hadjidakis DJ, Halvatsiotis PG, Ioannou YJ, et al. The effects of the somatostatin analogue SMS 201-995 on carbohydrate homeostasis of insulin-dependent diabetics as assessed by the artificial endocrine pancreas. Diabetes Res Clin Pract. 1988;5(2):91-8.
Hadjidakis, D. J., Halvatsiotis, P. G., Ioannou, Y. J., Mavrokefalos, P. J., & Raptis, S. A. (1988). The effects of the somatostatin analogue SMS 201-995 on carbohydrate homeostasis of insulin-dependent diabetics as assessed by the artificial endocrine pancreas. Diabetes Research and Clinical Practice, 5(2), 91-8.
Hadjidakis DJ, et al. The Effects of the Somatostatin Analogue SMS 201-995 On Carbohydrate Homeostasis of Insulin-dependent Diabetics as Assessed By the Artificial Endocrine Pancreas. Diabetes Res Clin Pract. 1988 Jul 13;5(2):91-8. PubMed PMID: 2901329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of the somatostatin analogue SMS 201-995 on carbohydrate homeostasis of insulin-dependent diabetics as assessed by the artificial endocrine pancreas. AU - Hadjidakis,D J, AU - Halvatsiotis,P G, AU - Ioannou,Y J, AU - Mavrokefalos,P J, AU - Raptis,S A, PY - 1988/7/13/pubmed PY - 1988/7/13/medline PY - 1988/7/13/entrez SP - 91 EP - 8 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 5 IS - 2 N2 - On the basis of the inhibitory actions of the somatostatin analogue SMS 201-995 on growth hormone (GH) and glucagon (IRG) secretion we investigated its effects on carbohydrate metabolism of insulin-dependent diabetics. Six patients with no residual insulin secretion were connected to the artificial endocrine pancreas (AEP) and after the establishment of a steady state overnight they were injected either normal saline or 50 micrograms of SMS 201-995 s.c., t.i.d., or 100 micrograms of the same compound b.i.d. Insulin requirements were assessed by the AEP and compared during the 24 h and after the main meals. The inhibition of GH and IRG secretion was evaluated as well. 50 micrograms of SMS analogue t.i.d. induced a significant reduction of insulin requirement (mean +/- SEM) while no significant difference was observed between control and 100 micrograms s.c., b.i.d., nor between 50 micrograms and 100 micrograms. The curve of glucose fluctuations was smoother after 50 micrograms than after 100 micrograms and control. Postprandial IRG secretion was inhibited by both regimens of SMS after lunch and dinner. GH secretion was significantly inhibited after all meals during the days of analogue administration. SMS 201-995 analogue appears to have a remarkable antidiabetic activity as shown by the sparing of administered amount of insulin, suppression of counter-insulin hormones and smoothing of blood glucose curve. It may constitute a safe and effective adjunctive measure in the management of insulin-dependent diabetics. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/2901329/The_effects_of_the_somatostatin_analogue_SMS_201_995_on_carbohydrate_homeostasis_of_insulin_dependent_diabetics_as_assessed_by_the_artificial_endocrine_pancreas_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(88)80047-0 DB - PRIME DP - Unbound Medicine ER -