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Differences in the stimulus properties of 3,4-methylenedioxyamphetamine and 3,4- methylenedioxymethamphetamine in animals trained to discriminate hallucinogens from saline.
J Pharmacol Exp Ther. 1988 Sep; 246(3):866-70.JP

Abstract

The stimulus properties of 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA) and several related compounds were compared to those of (+)-lysergic acid diethylamide (LSD) and mescaline (3,4,5-trimethoxyphenylethylamine) in a two-lever, water-reinforced, drug discrimination task. In animals trained to discriminate LSD (0.08 mg/kg) from saline (n = 8), LSD-like responding occurred during substitution (generalization) tests with sufficiently high doses of (+/-)-2,5-dimethoxy-4-methylamphetamine, LSD, mescaline, psilocybin and (-)-MDA; saline appropriate responding occurred after (+)-MDA and both (+)- and (+)- and (-)-MDMA. In animals trained to discriminate mescaline (10 mg/kg; n = 8), (-)-MDA, (+)-MDA, (-)-MDMA and (+)-MDMA as well as (+/-)-2,5-dimethoxy-4-methylamphetamine, LSD, mescaline and psilocybin mimicked the training drug. Neither (+)-amphetamine nor cocaine produced mescaline-like responding; fenfluramine substituted partially for mescaline but not LSD. Because all of the phenylisopropylamine enantiomers mimicked the potent hallucinogen mescaline (10 mg/kg), these results do not support suggestions that similarities in the behavioral effects of "designer" drugs such as MDA and MDMA to those of hallucinogens are limited to (-)-MDA. They also indicate that, although LSD and mescaline may be pharmacologically similar (in other assays), these compounds do not have identical stimulus properties.

Authors+Show Affiliations

Department of Psychology, University of South Carolina, Columbia.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2901488

Citation

Callahan, P M., and J B. Appel. "Differences in the Stimulus Properties of 3,4-methylenedioxyamphetamine and 3,4- Methylenedioxymethamphetamine in Animals Trained to Discriminate Hallucinogens From Saline." The Journal of Pharmacology and Experimental Therapeutics, vol. 246, no. 3, 1988, pp. 866-70.
Callahan PM, Appel JB. Differences in the stimulus properties of 3,4-methylenedioxyamphetamine and 3,4- methylenedioxymethamphetamine in animals trained to discriminate hallucinogens from saline. J Pharmacol Exp Ther. 1988;246(3):866-70.
Callahan, P. M., & Appel, J. B. (1988). Differences in the stimulus properties of 3,4-methylenedioxyamphetamine and 3,4- methylenedioxymethamphetamine in animals trained to discriminate hallucinogens from saline. The Journal of Pharmacology and Experimental Therapeutics, 246(3), 866-70.
Callahan PM, Appel JB. Differences in the Stimulus Properties of 3,4-methylenedioxyamphetamine and 3,4- Methylenedioxymethamphetamine in Animals Trained to Discriminate Hallucinogens From Saline. J Pharmacol Exp Ther. 1988;246(3):866-70. PubMed PMID: 2901488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in the stimulus properties of 3,4-methylenedioxyamphetamine and 3,4- methylenedioxymethamphetamine in animals trained to discriminate hallucinogens from saline. AU - Callahan,P M, AU - Appel,J B, PY - 1988/9/1/pubmed PY - 1988/9/1/medline PY - 1988/9/1/entrez SP - 866 EP - 70 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 246 IS - 3 N2 - The stimulus properties of 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA) and several related compounds were compared to those of (+)-lysergic acid diethylamide (LSD) and mescaline (3,4,5-trimethoxyphenylethylamine) in a two-lever, water-reinforced, drug discrimination task. In animals trained to discriminate LSD (0.08 mg/kg) from saline (n = 8), LSD-like responding occurred during substitution (generalization) tests with sufficiently high doses of (+/-)-2,5-dimethoxy-4-methylamphetamine, LSD, mescaline, psilocybin and (-)-MDA; saline appropriate responding occurred after (+)-MDA and both (+)- and (+)- and (-)-MDMA. In animals trained to discriminate mescaline (10 mg/kg; n = 8), (-)-MDA, (+)-MDA, (-)-MDMA and (+)-MDMA as well as (+/-)-2,5-dimethoxy-4-methylamphetamine, LSD, mescaline and psilocybin mimicked the training drug. Neither (+)-amphetamine nor cocaine produced mescaline-like responding; fenfluramine substituted partially for mescaline but not LSD. Because all of the phenylisopropylamine enantiomers mimicked the potent hallucinogen mescaline (10 mg/kg), these results do not support suggestions that similarities in the behavioral effects of "designer" drugs such as MDA and MDMA to those of hallucinogens are limited to (-)-MDA. They also indicate that, although LSD and mescaline may be pharmacologically similar (in other assays), these compounds do not have identical stimulus properties. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/2901488/Differences_in_the_stimulus_properties_of_34_methylenedioxyamphetamine_and_34__methylenedioxymethamphetamine_in_animals_trained_to_discriminate_hallucinogens_from_saline_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=2901488 DB - PRIME DP - Unbound Medicine ER -