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Imported malaria in Spain (2009-2016): results from the +REDIVI Collaborative Network.
Malar J. 2017 10 10; 16(1):407.MJ

Abstract

BACKGROUND

Imported malaria is a frequent diagnosis in travellers and migrants. The objective of this study was to describe the epidemiological and clinical characteristics of patients diagnosed with imported malaria within a Spanish collaborative network registering imported diseases (+REDIVI). In addition, the possible association between malaria and type of case, gender, age or area of exposure was explored.

METHODS

Cases of imported malaria were identified among all cases registered in the +REDIVI database during the period October 2009-October 2016. Demographic, epidemiological and clinical characteristics were analysed.

RESULTS

In total, 11,816 cases of imported infectious diseases were registered in +REDIVI's database between October 2009 and October 2016. Immigrants seen for the first time after migration accounted for 60.2% of cases, 21.0% of patients were travellers, and 18.8% were travellers/immigrants visiting friends and relatives (VFRs). There were 850 cases of malaria (850/11,816, 7.2%). Malaria was significantly more frequent in men than in women (56.8% vs 43.2%) and in VFR-immigrants (52.6%) as compared to travellers (21.3%), immigrants (20.7%) and VFR-travellers (5.4%) (p < 0.001). Although this data was not available for most patients with malaria, only a minority (29/217, 13.4%) mentioned correct anti-malarial prophylaxis. Sub-Saharan Africa was found to be the most common region of acquisition of malaria. Most common reason for consultation after travel was a febrile syndrome although an important proportion of immigrants were asymptomatic and presented only for health screening (27.3%). Around 5% of travellers presented with severe malaria. The most prevalent species of Plasmodium diagnosed was Plasmodium falciparum (81.5%). Malaria due to Plasmodium ovale/Plasmodium vivax was frequent among travellers (17%) and nearly 5% of all malaria cases in immigrants were caused by Plasmodium malariae.

CONCLUSIONS

Malaria was among the five most frequent diagnoses registered in +REDIVI's database. Some significant differences were found in the distribution of malaria according to gender, type of case, species. Among all malaria cases, the most frequent diagnosis was P. falciparum infection in VFR-immigrant men.

Authors+Show Affiliations

National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Ctra Colmenar, Km 9,100, 28034, Madrid, Spain. ffnorman@gmail.com.National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Ctra Colmenar, Km 9,100, 28034, Madrid, Spain.Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, PROSICS Barcelona, Barcelona, Spain.Unitat Medicina Tropical i Salut Internacional Vall d'Hebron-Drassanes, PROSICS Barcelona, Barcelona, Spain.La Fe de Valencia University Hospital, Valencia, Spain.Alicante University Hospital, Alicante, Spain.Unitat Medicina Tropical i Salut Internacional Vall d'Hebron-Drassanes, PROSICS Barcelona, Barcelona, Spain.Fuenlabrada Hospital, Madrid, Spain.National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Ctra Colmenar, Km 9,100, 28034, Madrid, Spain.National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Ctra Colmenar, Km 9,100, 28034, Madrid, Spain.12 de Octubre University Hospital, Madrid, Spain.Valencia General University Hospital, Valencia, Spain.Asturias Central University Hospital, Oviedo, Spain.Albacete University Hospital, Albacete, Spain.Basurto University Hospital, Bilbao, Spain.National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Ctra Colmenar, Km 9,100, 28034, Madrid, Spain.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29017499

Citation

Norman, Francesca F., et al. "Imported Malaria in Spain (2009-2016): Results From the +REDIVI Collaborative Network." Malaria Journal, vol. 16, no. 1, 2017, p. 407.
Norman FF, López-Polín A, Salvador F, et al. Imported malaria in Spain (2009-2016): results from the +REDIVI Collaborative Network. Malar J. 2017;16(1):407.
Norman, F. F., López-Polín, A., Salvador, F., Treviño, B., Calabuig, E., Torrús, D., Soriano-Arandes, A., Ruíz-Giardín, J. M., Monge-Maillo, B., Pérez-Molina, J. A., Perez-Ayala, A., García, M., Rodríguez, A., Martínez-Serrano, M., Zubero, M., & López-Vélez, R. (2017). Imported malaria in Spain (2009-2016): results from the +REDIVI Collaborative Network. Malaria Journal, 16(1), 407. https://doi.org/10.1186/s12936-017-2057-8
Norman FF, et al. Imported Malaria in Spain (2009-2016): Results From the +REDIVI Collaborative Network. Malar J. 2017 10 10;16(1):407. PubMed PMID: 29017499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Imported malaria in Spain (2009-2016): results from the +REDIVI Collaborative Network. AU - Norman,Francesca F, AU - López-Polín,Ana, AU - Salvador,Fernando, AU - Treviño,Begoña, AU - Calabuig,Eva, AU - Torrús,Diego, AU - Soriano-Arandes,Antonio, AU - Ruíz-Giardín,Jose-Manuel, AU - Monge-Maillo,Begoña, AU - Pérez-Molina,Jose-Antonio, AU - Perez-Ayala,Ana, AU - García,Magdalena, AU - Rodríguez,Azucena, AU - Martínez-Serrano,María, AU - Zubero,Miren, AU - López-Vélez,Rogelio, AU - ,, Y1 - 2017/10/10/ PY - 2017/08/04/received PY - 2017/10/06/accepted PY - 2017/10/12/entrez PY - 2017/10/12/pubmed PY - 2018/5/15/medline SP - 407 EP - 407 JF - Malaria journal JO - Malar J VL - 16 IS - 1 N2 - BACKGROUND: Imported malaria is a frequent diagnosis in travellers and migrants. The objective of this study was to describe the epidemiological and clinical characteristics of patients diagnosed with imported malaria within a Spanish collaborative network registering imported diseases (+REDIVI). In addition, the possible association between malaria and type of case, gender, age or area of exposure was explored. METHODS: Cases of imported malaria were identified among all cases registered in the +REDIVI database during the period October 2009-October 2016. Demographic, epidemiological and clinical characteristics were analysed. RESULTS: In total, 11,816 cases of imported infectious diseases were registered in +REDIVI's database between October 2009 and October 2016. Immigrants seen for the first time after migration accounted for 60.2% of cases, 21.0% of patients were travellers, and 18.8% were travellers/immigrants visiting friends and relatives (VFRs). There were 850 cases of malaria (850/11,816, 7.2%). Malaria was significantly more frequent in men than in women (56.8% vs 43.2%) and in VFR-immigrants (52.6%) as compared to travellers (21.3%), immigrants (20.7%) and VFR-travellers (5.4%) (p < 0.001). Although this data was not available for most patients with malaria, only a minority (29/217, 13.4%) mentioned correct anti-malarial prophylaxis. Sub-Saharan Africa was found to be the most common region of acquisition of malaria. Most common reason for consultation after travel was a febrile syndrome although an important proportion of immigrants were asymptomatic and presented only for health screening (27.3%). Around 5% of travellers presented with severe malaria. The most prevalent species of Plasmodium diagnosed was Plasmodium falciparum (81.5%). Malaria due to Plasmodium ovale/Plasmodium vivax was frequent among travellers (17%) and nearly 5% of all malaria cases in immigrants were caused by Plasmodium malariae. CONCLUSIONS: Malaria was among the five most frequent diagnoses registered in +REDIVI's database. Some significant differences were found in the distribution of malaria according to gender, type of case, species. Among all malaria cases, the most frequent diagnosis was P. falciparum infection in VFR-immigrant men. SN - 1475-2875 UR - https://www.unboundmedicine.com/medline/citation/29017499/Imported_malaria_in_Spain__2009_2016_:_results_from_the_+REDIVI_Collaborative_Network_ L2 - https://malariajournal.biomedcentral.com/articles/10.1186/s12936-017-2057-8 DB - PRIME DP - Unbound Medicine ER -