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The role of cognitive reserve in cognitive aging: what we can learn from Parkinson's disease.
Aging Clin Exp Res. 2018 Jul; 30(7):877-880.AC

Abstract

Parkinson's disease (PD) typically occurs in elderly people and some degree of cognitive impairment is usually present. Cognitive reserve (CR) theory was proposed to explain the discrepancy between the degree of brain pathologies and clinical manifestations. We administered a comprehensive neuropsychological battery to 35 non-demented participants affected by PD. All participants underwent also the Cognitive Reserve Index questionnaire and the Brief Intelligence Test as proxies for CR. Relationships between CR and cognitive performance were investigated by linear regression analyses, adjusting for significant confounding factors. At linear regression analyses, higher CR scores were independently associated with a better performance on Word Fluency (p ≤ 0.04) and Digit Span (backward) (p ≤ 0.02); no associations were observed between CR and other cognitive tests. Our data provide empirical support to the relation between CR and cognitive impairment in PD. In particular, this study suggests that CR may have greater effects on the cognitive areas mostly affected in PD as executive functions.

Authors+Show Affiliations

Department of Psychology, Catholic University, Largo Agostino Gemelli 1, 20123, Milan, Italy. nicoletta.ciccarelli@gmail.com.Center for Medicine of the Aging, Policlinico Gemelli Foundation, Rome, Italy.Center for Medicine of the Aging, Policlinico Gemelli Foundation, Rome, Italy.Center for Medicine of the Aging, Policlinico Gemelli Foundation, Rome, Italy. Karolinska Institute and Stockholm University, Stockholm, Sweden.Center for Medicine of the Aging, Policlinico Gemelli Foundation, Rome, Italy. Catholic University, Rome, Italy.Center for Medicine of the Aging, Policlinico Gemelli Foundation, Rome, Italy. Catholic University, Rome, Italy.Center for Medicine of the Aging, Policlinico Gemelli Foundation, Rome, Italy.Center for Medicine of the Aging, Policlinico Gemelli Foundation, Rome, Italy.Department of Psychology, Catholic University, Largo Agostino Gemelli 1, 20123, Milan, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29019160

Citation

Ciccarelli, Nicoletta, et al. "The Role of Cognitive Reserve in Cognitive Aging: what We Can Learn From Parkinson's Disease." Aging Clinical and Experimental Research, vol. 30, no. 7, 2018, pp. 877-880.
Ciccarelli N, Monaco MRL, Fusco D, et al. The role of cognitive reserve in cognitive aging: what we can learn from Parkinson's disease. Aging Clin Exp Res. 2018;30(7):877-880.
Ciccarelli, N., Monaco, M. R. L., Fusco, D., Vetrano, D. L., Zuccalà, G., Bernabei, R., Brandi, V., Pisciotta, M. S., & Silveri, M. C. (2018). The role of cognitive reserve in cognitive aging: what we can learn from Parkinson's disease. Aging Clinical and Experimental Research, 30(7), 877-880. https://doi.org/10.1007/s40520-017-0838-0
Ciccarelli N, et al. The Role of Cognitive Reserve in Cognitive Aging: what We Can Learn From Parkinson's Disease. Aging Clin Exp Res. 2018;30(7):877-880. PubMed PMID: 29019160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of cognitive reserve in cognitive aging: what we can learn from Parkinson's disease. AU - Ciccarelli,Nicoletta, AU - Monaco,Maria Rita Lo, AU - Fusco,Domenico, AU - Vetrano,Davide Liborio, AU - Zuccalà,Giuseppe, AU - Bernabei,Roberto, AU - Brandi,Vincenzo, AU - Pisciotta,Maria Stella, AU - Silveri,Maria Caterina, Y1 - 2017/10/11/ PY - 2017/06/11/received PY - 2017/09/25/accepted PY - 2017/10/12/pubmed PY - 2018/10/10/medline PY - 2017/10/12/entrez KW - Aging KW - Cognitive reserve KW - Executive functions KW - Neuropsychological examination SP - 877 EP - 880 JF - Aging clinical and experimental research JO - Aging Clin Exp Res VL - 30 IS - 7 N2 - Parkinson's disease (PD) typically occurs in elderly people and some degree of cognitive impairment is usually present. Cognitive reserve (CR) theory was proposed to explain the discrepancy between the degree of brain pathologies and clinical manifestations. We administered a comprehensive neuropsychological battery to 35 non-demented participants affected by PD. All participants underwent also the Cognitive Reserve Index questionnaire and the Brief Intelligence Test as proxies for CR. Relationships between CR and cognitive performance were investigated by linear regression analyses, adjusting for significant confounding factors. At linear regression analyses, higher CR scores were independently associated with a better performance on Word Fluency (p ≤ 0.04) and Digit Span (backward) (p ≤ 0.02); no associations were observed between CR and other cognitive tests. Our data provide empirical support to the relation between CR and cognitive impairment in PD. In particular, this study suggests that CR may have greater effects on the cognitive areas mostly affected in PD as executive functions. SN - 1720-8319 UR - https://www.unboundmedicine.com/medline/citation/29019160/The_role_of_cognitive_reserve_in_cognitive_aging:_what_we_can_learn_from_Parkinson's_disease_ L2 - https://dx.doi.org/10.1007/s40520-017-0838-0 DB - PRIME DP - Unbound Medicine ER -