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[Research progress of CRISPR-Cas9 system for gene therapy].
Sheng Wu Gong Cheng Xue Bao. 2016 Jul 25; 32(7):861-869.SW

Abstract

The clustered regulatory interspaced short palindromic repeat-Cas9 (CRISPR-Cas9) system is the part of the prokaryotic immune system, which could recognize and delete the exogenous sequences originated from virus or plasmid. Based on its mechanism, CRISPR-Cas9 system was developed into the new generation of gene editing tool. Compared to the existed technologies such as ES targeting, ZFN or TALEN, CRISPR-Cas9 system is a more efficient, economical and promising approach to manipulate the genome. In this review, we summarize the research progress about CRISPR-Cas9 technology, especially the latest applications in gene therapy studies of human diseases.

Authors+Show Affiliations

School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.

Pub Type(s)

Journal Article
Review

Language

chi

PubMed ID

29019208

Citation

Zhan, Changsheng, and Xiaoyu Xia. "[Research Progress of CRISPR-Cas9 System for Gene Therapy]." Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology, vol. 32, no. 7, 2016, pp. 861-869.
Zhan C, Xia X. [Research progress of CRISPR-Cas9 system for gene therapy]. Sheng Wu Gong Cheng Xue Bao. 2016;32(7):861-869.
Zhan, C., & Xia, X. (2016). [Research progress of CRISPR-Cas9 system for gene therapy]. Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology, 32(7), 861-869. https://doi.org/10.13345/j.cjb.150542
Zhan C, Xia X. [Research Progress of CRISPR-Cas9 System for Gene Therapy]. Sheng Wu Gong Cheng Xue Bao. 2016 Jul 25;32(7):861-869. PubMed PMID: 29019208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Research progress of CRISPR-Cas9 system for gene therapy]. AU - Zhan,Changsheng, AU - Xia,Xiaoyu, PY - 2017/10/12/entrez PY - 2016/7/25/pubmed PY - 2018/3/15/medline KW - CRISPR-Cas9 technology KW - disease model KW - gene editing KW - gene therapy KW - personalized medicine SP - 861 EP - 869 JF - Sheng wu gong cheng xue bao = Chinese journal of biotechnology JO - Sheng Wu Gong Cheng Xue Bao VL - 32 IS - 7 N2 - The clustered regulatory interspaced short palindromic repeat-Cas9 (CRISPR-Cas9) system is the part of the prokaryotic immune system, which could recognize and delete the exogenous sequences originated from virus or plasmid. Based on its mechanism, CRISPR-Cas9 system was developed into the new generation of gene editing tool. Compared to the existed technologies such as ES targeting, ZFN or TALEN, CRISPR-Cas9 system is a more efficient, economical and promising approach to manipulate the genome. In this review, we summarize the research progress about CRISPR-Cas9 technology, especially the latest applications in gene therapy studies of human diseases. SN - 1000-3061 UR - https://www.unboundmedicine.com/medline/citation/29019208/[Research_progress_of_CRISPR_Cas9_system_for_gene_therapy]_ L2 - https://doi.org/10.13345/j.cjb.150542 DB - PRIME DP - Unbound Medicine ER -