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Association of khellin and 308-nm excimer lamp in the treatment of severe alopecia areata in a child.
J Cosmet Laser Ther. 2018 Jun; 20(3):156-158.JC

Abstract

Alopecia areata (AA) is an autoimmune inflammatory disorder of hair, characterized by non-scarring hair loss. A 308-nm excimer lamp (EL) has been reported as one effective modality in the treatment of AA. Khellin is a furanochromone photosensitizer whose chemical structure is close to psoralens and has previously proven its efficacy in vitiligo in association with ultraviolet A. We evaluated the efficacy and safety of a combination of topical khellin and 308-nm EL in the treatment of a refractory ophiasic AA, of 1-year evolution, in a 5-year-old boy. Treatment consisted in topical application of khellin 45 mn before irradiation with EL (starting dose 50 mJ/cm2) twice a week for 3 months. The result was a complete regrowth of hair with no recurrence 1 year later. Further studies should be carried out to confirm this promising result and to propose khellin-excimer as a new alternative treatment for resistant cases of AA in children.

Authors+Show Affiliations

a Department of Dermatology , Habib Thameur Hospital , Tunis , Tunisia. b Research Laboratory Genodermatosis and cancer LR12SP03.a Department of Dermatology , Habib Thameur Hospital , Tunis , Tunisia. b Research Laboratory Genodermatosis and cancer LR12SP03.b Research Laboratory Genodermatosis and cancer LR12SP03.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29020475

Citation

Fenniche, Samy, et al. "Association of Khellin and 308-nm Excimer Lamp in the Treatment of Severe Alopecia Areata in a Child." Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology, vol. 20, no. 3, 2018, pp. 156-158.
Fenniche S, Hammami H, Zaouak A. Association of khellin and 308-nm excimer lamp in the treatment of severe alopecia areata in a child. J Cosmet Laser Ther. 2018;20(3):156-158.
Fenniche, S., Hammami, H., & Zaouak, A. (2018). Association of khellin and 308-nm excimer lamp in the treatment of severe alopecia areata in a child. Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology, 20(3), 156-158. https://doi.org/10.1080/14764172.2017.1383617
Fenniche S, Hammami H, Zaouak A. Association of Khellin and 308-nm Excimer Lamp in the Treatment of Severe Alopecia Areata in a Child. J Cosmet Laser Ther. 2018;20(3):156-158. PubMed PMID: 29020475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of khellin and 308-nm excimer lamp in the treatment of severe alopecia areata in a child. AU - Fenniche,Samy, AU - Hammami,Houda, AU - Zaouak,Anissa, Y1 - 2017/12/13/ PY - 2017/10/12/pubmed PY - 2018/9/20/medline PY - 2017/10/12/entrez KW - Khellin KW - alopecia areata KW - excimer SP - 156 EP - 158 JF - Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology JO - J Cosmet Laser Ther VL - 20 IS - 3 N2 - Alopecia areata (AA) is an autoimmune inflammatory disorder of hair, characterized by non-scarring hair loss. A 308-nm excimer lamp (EL) has been reported as one effective modality in the treatment of AA. Khellin is a furanochromone photosensitizer whose chemical structure is close to psoralens and has previously proven its efficacy in vitiligo in association with ultraviolet A. We evaluated the efficacy and safety of a combination of topical khellin and 308-nm EL in the treatment of a refractory ophiasic AA, of 1-year evolution, in a 5-year-old boy. Treatment consisted in topical application of khellin 45 mn before irradiation with EL (starting dose 50 mJ/cm2) twice a week for 3 months. The result was a complete regrowth of hair with no recurrence 1 year later. Further studies should be carried out to confirm this promising result and to propose khellin-excimer as a new alternative treatment for resistant cases of AA in children. SN - 1476-4180 UR - https://www.unboundmedicine.com/medline/citation/29020475/Association_of_khellin_and_308_nm_excimer_lamp_in_the_treatment_of_severe_alopecia_areata_in_a_child_ L2 - http://www.tandfonline.com/doi/full/10.1080/14764172.2017.1383617 DB - PRIME DP - Unbound Medicine ER -