Tags

Type your tag names separated by a space and hit enter

The prognostic value of pretreatment tumor apparent diffusion coefficient values in nasopharyngeal carcinoma.
BMC Cancer 2017; 17(1):678BC

Abstract

BACKGROUND

Diffusion-weighted MR imaging (DWI) has increasingly contributed to the management of nasopharyngeal carcinoma (NPC) patients. The objective of this paper was to explore the prognostic significance of apparent diffusion coefficient (ADC) values in 93 NPC patients.

METHODS

This retrospective study included 93 newly diagnosed NPC patients. Pretreatment ADC values were determined and compared with patients' age, gender, alcohol intake, smoking, tumor volume, pathological type, tumor stage, and nodal stage. Using the Kaplan-Meier method, overall survival (OS), local relapse-free survival (LRFS), and distant metastasis-free survival (DMFS) were calculated and the values compared between the low and high ADC groups. Multivariate analysis of ADC values and other 9 clinical parameters was performed using a Cox proportional hazards model to test the independent significance for OS, LRFS and DMFS.

RESULTS

The mean ADC value for the initial nasopharyngeal tumors was 0.72 × 10-3 mm2/s (range: 0.48-0.97 × 10-3 mm2/s). There was no significant difference between pretreatment ADCs and patient' gender, age, smoking, alcohol intake, or tumor stage. A significant difference in the ADCs for different N stages (P = 0.022) and correlation with initial tumor volume (r = -0.26, P = 0.012) were observed. In comparison, the ADC value for undifferentiated carcinoma was lower than that for other 3 pathological types. With a median follow-up period of 50 months, the 3-year and 5-year OS rates were 88.2% and 83.3%, respectively, 3-year and 5-year LRFS rates were 93.5% and 93.3%, respectively, and 3-year and 5-year DMFS rates were 83.9% and 83.3%, respectively. Patients with tumor ADC values ≥0.72 × 10-3 mm2/s exhibited longer OS and LRFS periods compared with tumor ADC values <0.72 × 10-3 mm2/s, with P values 0.036 and 0.018, respectively. In addition, patients with deaths or recurrences or distant metastasis had significant lower ADC values than those without disease failures. According to a multivariate analysis using the Cox proportional hazard test, ADC values showed a significant correlation with OS (P = 0.0004), LRFS (P = 0.0009), and DMFS (P < 0.0001), respectively.

CONCLUSIONS

Pretreatment tumor ADC values supposed to be a noninvasive important prognostic parameter for NPC.

Authors+Show Affiliations

Department of Radiation Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, People's Republic of China.Department of Radiation Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, People's Republic of China.Department of Radiation Oncology, Henan Province People's Hospital, Zhengzhou, Henan, 450000, China.Department of Radiation Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, People's Republic of China.Department of Radiation Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, People's Republic of China. yansenxiang@zju.edu.cn.Department of Radiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, Hangzhou, 310003, China.Department of Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Zhejiang, Hangzhou, 310003, China. Lsteng@zju.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29020937

Citation

Yan, Dan-Fang, et al. "The Prognostic Value of Pretreatment Tumor Apparent Diffusion Coefficient Values in Nasopharyngeal Carcinoma." BMC Cancer, vol. 17, no. 1, 2017, p. 678.
Yan DF, Zhang WB, Ke SB, et al. The prognostic value of pretreatment tumor apparent diffusion coefficient values in nasopharyngeal carcinoma. BMC Cancer. 2017;17(1):678.
Yan, D. F., Zhang, W. B., Ke, S. B., Zhao, F., Yan, S. X., Wang, Q. D., & Teng, L. S. (2017). The prognostic value of pretreatment tumor apparent diffusion coefficient values in nasopharyngeal carcinoma. BMC Cancer, 17(1), p. 678. doi:10.1186/s12885-017-3658-x.
Yan DF, et al. The Prognostic Value of Pretreatment Tumor Apparent Diffusion Coefficient Values in Nasopharyngeal Carcinoma. BMC Cancer. 2017 Oct 11;17(1):678. PubMed PMID: 29020937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prognostic value of pretreatment tumor apparent diffusion coefficient values in nasopharyngeal carcinoma. AU - Yan,Dan-Fang, AU - Zhang,Wen-Bao, AU - Ke,Shan-Bao, AU - Zhao,Feng, AU - Yan,Sen-Xiang, AU - Wang,Qi-Dong, AU - Teng,Li-Song, Y1 - 2017/10/11/ PY - 2016/12/16/received PY - 2017/09/26/accepted PY - 2017/10/13/entrez PY - 2017/10/13/pubmed PY - 2018/5/31/medline KW - Apparent diffusion coefficient value KW - Diffusion-weighted magnetic resonance imaging KW - Nasopharyngeal carcinoma SP - 678 EP - 678 JF - BMC cancer JO - BMC Cancer VL - 17 IS - 1 N2 - BACKGROUND: Diffusion-weighted MR imaging (DWI) has increasingly contributed to the management of nasopharyngeal carcinoma (NPC) patients. The objective of this paper was to explore the prognostic significance of apparent diffusion coefficient (ADC) values in 93 NPC patients. METHODS: This retrospective study included 93 newly diagnosed NPC patients. Pretreatment ADC values were determined and compared with patients' age, gender, alcohol intake, smoking, tumor volume, pathological type, tumor stage, and nodal stage. Using the Kaplan-Meier method, overall survival (OS), local relapse-free survival (LRFS), and distant metastasis-free survival (DMFS) were calculated and the values compared between the low and high ADC groups. Multivariate analysis of ADC values and other 9 clinical parameters was performed using a Cox proportional hazards model to test the independent significance for OS, LRFS and DMFS. RESULTS: The mean ADC value for the initial nasopharyngeal tumors was 0.72 × 10-3 mm2/s (range: 0.48-0.97 × 10-3 mm2/s). There was no significant difference between pretreatment ADCs and patient' gender, age, smoking, alcohol intake, or tumor stage. A significant difference in the ADCs for different N stages (P = 0.022) and correlation with initial tumor volume (r = -0.26, P = 0.012) were observed. In comparison, the ADC value for undifferentiated carcinoma was lower than that for other 3 pathological types. With a median follow-up period of 50 months, the 3-year and 5-year OS rates were 88.2% and 83.3%, respectively, 3-year and 5-year LRFS rates were 93.5% and 93.3%, respectively, and 3-year and 5-year DMFS rates were 83.9% and 83.3%, respectively. Patients with tumor ADC values ≥0.72 × 10-3 mm2/s exhibited longer OS and LRFS periods compared with tumor ADC values <0.72 × 10-3 mm2/s, with P values 0.036 and 0.018, respectively. In addition, patients with deaths or recurrences or distant metastasis had significant lower ADC values than those without disease failures. According to a multivariate analysis using the Cox proportional hazard test, ADC values showed a significant correlation with OS (P = 0.0004), LRFS (P = 0.0009), and DMFS (P < 0.0001), respectively. CONCLUSIONS: Pretreatment tumor ADC values supposed to be a noninvasive important prognostic parameter for NPC. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/29020937/The_prognostic_value_of_pretreatment_tumor_apparent_diffusion_coefficient_values_in_nasopharyngeal_carcinoma_ L2 - https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3658-x DB - PRIME DP - Unbound Medicine ER -