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Relation of four nontraditional lipid profiles to diabetes in rural Chinese H-type hypertension population.
Lipids Health Dis. 2017 Oct 11; 16(1):199.LH

Abstract

BACKGROUND

Mounting evidence suggested that nontraditional lipid profiles have been recognized as a reliable indicator for unfavorable cardiovascular events. The purpose of this study was to explore the role of nontraditional lipid profiles as potential clinical indices for the assessment of prevalent diabetes in rural Chinese H-type hypertension population.

METHODS

During 2012 to 2013, we conducted a large cross-sectional study of 2944 H-type hypertension participants (≥35 years of age) from rural areas in northeast China. Subjects underwent accurate assessment of lipid profiles, fasting plasma glucose (FPG), homocysteine (Hcy) according to standard protocols.

RESULTS

The proportion of diabetes showed a graded and linear increase across the quartiles for all four nontraditional lipid parameters. Nontraditional lipid variables were independent determinants of FPG, and its correlation for TG/HDL-C was strongest, whether potential confounders were adjusted or not. Multivariable logistic regression analysis established that the highest triglycerides (TG)/ high-density lipoprotein cholesterol (HDL-C) quartile manifested the largest ORs of prevalent diabetes (OR: 3.275, 95%CI: 2.109-5.087) compared with the lowest quartile. The fully adjusted ORs (95%CI) were 2.753 (1.783-4.252), 2.178 (1.415-2.351), 1.648 (1.097-2.478) for the top quartile of total cholesterol (TC)/HDL-C, low-density lipoprotein cholesterol (LDL-C)/HDL-C, and non-high-density lipoprotein cholesterol (non-HDL-C), respectively. On the basis of the area under receiver-operating characteristic curve (AUC), TG/HDL-C showed the optimal discriminating power for diabetes (AUC: 0.684, 95% CI: 0.650-0.718).

CONCLUSIONS

Nontraditional lipid profiles (TG/HDL-C, TC/HDL-C, LDL-C/HDL-C and non-HDL-C) were all consistently and independently correlated with prevalent diabetes among the H-type hypertension population in rural China. TG/HDL-C was prone to be more profitable in assessing the risk of prevalent diabetes and should be encouraged as an effective clinical tool for monitoring and targeted intervention of diabetes in H-type hypertension adults.

Authors+Show Affiliations

Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China. yxsun@mail.cmu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29020963

Citation

Wang, Haoyu, et al. "Relation of Four Nontraditional Lipid Profiles to Diabetes in Rural Chinese H-type Hypertension Population." Lipids in Health and Disease, vol. 16, no. 1, 2017, p. 199.
Wang H, Guo X, Chen Y, et al. Relation of four nontraditional lipid profiles to diabetes in rural Chinese H-type hypertension population. Lipids Health Dis. 2017;16(1):199.
Wang, H., Guo, X., Chen, Y., Li, Z., Xu, J., & Sun, Y. (2017). Relation of four nontraditional lipid profiles to diabetes in rural Chinese H-type hypertension population. Lipids in Health and Disease, 16(1), 199. https://doi.org/10.1186/s12944-017-0590-7
Wang H, et al. Relation of Four Nontraditional Lipid Profiles to Diabetes in Rural Chinese H-type Hypertension Population. Lipids Health Dis. 2017 Oct 11;16(1):199. PubMed PMID: 29020963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of four nontraditional lipid profiles to diabetes in rural Chinese H-type hypertension population. AU - Wang,Haoyu, AU - Guo,Xiaofan, AU - Chen,Yintao, AU - Li,Zhao, AU - Xu,Jiaqi, AU - Sun,Yingxian, Y1 - 2017/10/11/ PY - 2017/06/06/received PY - 2017/10/04/accepted PY - 2017/10/13/entrez PY - 2017/10/13/pubmed PY - 2018/6/2/medline KW - Diabetes KW - H-type hypertension KW - Lipid ratios KW - Lipids KW - Rural population SP - 199 EP - 199 JF - Lipids in health and disease JO - Lipids Health Dis VL - 16 IS - 1 N2 - BACKGROUND: Mounting evidence suggested that nontraditional lipid profiles have been recognized as a reliable indicator for unfavorable cardiovascular events. The purpose of this study was to explore the role of nontraditional lipid profiles as potential clinical indices for the assessment of prevalent diabetes in rural Chinese H-type hypertension population. METHODS: During 2012 to 2013, we conducted a large cross-sectional study of 2944 H-type hypertension participants (≥35 years of age) from rural areas in northeast China. Subjects underwent accurate assessment of lipid profiles, fasting plasma glucose (FPG), homocysteine (Hcy) according to standard protocols. RESULTS: The proportion of diabetes showed a graded and linear increase across the quartiles for all four nontraditional lipid parameters. Nontraditional lipid variables were independent determinants of FPG, and its correlation for TG/HDL-C was strongest, whether potential confounders were adjusted or not. Multivariable logistic regression analysis established that the highest triglycerides (TG)/ high-density lipoprotein cholesterol (HDL-C) quartile manifested the largest ORs of prevalent diabetes (OR: 3.275, 95%CI: 2.109-5.087) compared with the lowest quartile. The fully adjusted ORs (95%CI) were 2.753 (1.783-4.252), 2.178 (1.415-2.351), 1.648 (1.097-2.478) for the top quartile of total cholesterol (TC)/HDL-C, low-density lipoprotein cholesterol (LDL-C)/HDL-C, and non-high-density lipoprotein cholesterol (non-HDL-C), respectively. On the basis of the area under receiver-operating characteristic curve (AUC), TG/HDL-C showed the optimal discriminating power for diabetes (AUC: 0.684, 95% CI: 0.650-0.718). CONCLUSIONS: Nontraditional lipid profiles (TG/HDL-C, TC/HDL-C, LDL-C/HDL-C and non-HDL-C) were all consistently and independently correlated with prevalent diabetes among the H-type hypertension population in rural China. TG/HDL-C was prone to be more profitable in assessing the risk of prevalent diabetes and should be encouraged as an effective clinical tool for monitoring and targeted intervention of diabetes in H-type hypertension adults. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/29020963/Relation_of_four_nontraditional_lipid_profiles_to_diabetes_in_rural_Chinese_H_type_hypertension_population_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-017-0590-7 DB - PRIME DP - Unbound Medicine ER -