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Comorbidity of gastrointestinal disorders, migraine, and tension-type headache: a cross-sectional study in Iran.
Neurol Sci. 2018 Jan; 39(1):63-70.NS

Abstract

Migraine can be accompanied by some gastrointestinal (GI) disorders. In this study, we aimed to investigate the relationship between migraine and tension-type headache (TTH) and different lower and upper GI disorders as well as non-alcoholic fatty liver (NAFLD) and cholelithiasis. This cross-sectional study included 1574 overweight and obese participants who were referred to the Obesity Research Center of Sina Hospital, Tehran, Iran. The diagnosis of migraine and TTH was made by an expert neurologist based on the international classification of headache disorders-III β (ICHD III β). GI disorders, including irritable bowel syndrome (IBS), constipation, heartburn, dyspepsia, non-alcoholic fatty liver (NAFLD), and cholelithiasis, were diagnosed by a gastroenterology specialist. The overall mean age of participants was 37.44 ± 12.62. A total of 181 (11.5%) migraine sufferers (with and without aura) and 78 (5%) TTH subjects were diagnosed. After adjusting for potential confounders by multivariable regression models, migraine had significant association with IBS (OR = 5.16, 95% CI = 2.07-12.85, P = 0.000), constipation (OR = 3.96, 95% CI = 2.25-6.99, P = 0.000), dyspepsia (OR = 4.12, 95% CI = 2.63-6.45, P = 0.000), and heartburn (OR = 5.03, 95% CI 2.45-10.33, P = 0.000), while the association between migraine and NAFLD was marginally significant (OR = 2.03, 95% CI = 0.98-4.21, P = 0.055). Furthermore, the prevalence of NAFLD (OR = 2.93, 95% CI 1.29-6.65, P = 0.010) and dyspepsia (OR = 4.06, 95% CI = 2.24-7.34, P = 0.000) was significantly higher in TTH patients than the headache-free group. These findings show an association between GI disorders and primary headaches especially migraine and are, therefore, of value to the management of migraine and TTH. Further studies should investigate the etiology of the relationship between all subtypes of primary headaches and GI disorders.

Authors+Show Affiliations

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, West Arghavan St., Farahzadi Blvd, Tehran, Iran.Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.Community and Preventive Medicine Department, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran.Division of Gastroenterology, Department of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. razeghi@sina.tums.ac.ir.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29022143

Citation

Martami, Fahimeh, et al. "Comorbidity of Gastrointestinal Disorders, Migraine, and Tension-type Headache: a Cross-sectional Study in Iran." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 39, no. 1, 2018, pp. 63-70.
Martami F, Ghorbani Z, Abolhasani M, et al. Comorbidity of gastrointestinal disorders, migraine, and tension-type headache: a cross-sectional study in Iran. Neurol Sci. 2018;39(1):63-70.
Martami, F., Ghorbani, Z., Abolhasani, M., Togha, M., Meysamie, A., Sharifi, A., & Razeghi Jahromi, S. (2018). Comorbidity of gastrointestinal disorders, migraine, and tension-type headache: a cross-sectional study in Iran. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 39(1), 63-70. https://doi.org/10.1007/s10072-017-3141-0
Martami F, et al. Comorbidity of Gastrointestinal Disorders, Migraine, and Tension-type Headache: a Cross-sectional Study in Iran. Neurol Sci. 2018;39(1):63-70. PubMed PMID: 29022143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comorbidity of gastrointestinal disorders, migraine, and tension-type headache: a cross-sectional study in Iran. AU - Martami,Fahimeh, AU - Ghorbani,Zeinab, AU - Abolhasani,Maryam, AU - Togha,Mansoureh, AU - Meysamie,Alipasha, AU - Sharifi,Alireza, AU - Razeghi Jahromi,Soodeh, Y1 - 2017/10/11/ PY - 2017/05/05/received PY - 2017/10/03/accepted PY - 2017/10/13/pubmed PY - 2018/8/16/medline PY - 2017/10/13/entrez KW - Comorbidity KW - Gastrointestinal disorders KW - Migraine KW - Tension-type headache SP - 63 EP - 70 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 39 IS - 1 N2 - Migraine can be accompanied by some gastrointestinal (GI) disorders. In this study, we aimed to investigate the relationship between migraine and tension-type headache (TTH) and different lower and upper GI disorders as well as non-alcoholic fatty liver (NAFLD) and cholelithiasis. This cross-sectional study included 1574 overweight and obese participants who were referred to the Obesity Research Center of Sina Hospital, Tehran, Iran. The diagnosis of migraine and TTH was made by an expert neurologist based on the international classification of headache disorders-III β (ICHD III β). GI disorders, including irritable bowel syndrome (IBS), constipation, heartburn, dyspepsia, non-alcoholic fatty liver (NAFLD), and cholelithiasis, were diagnosed by a gastroenterology specialist. The overall mean age of participants was 37.44 ± 12.62. A total of 181 (11.5%) migraine sufferers (with and without aura) and 78 (5%) TTH subjects were diagnosed. After adjusting for potential confounders by multivariable regression models, migraine had significant association with IBS (OR = 5.16, 95% CI = 2.07-12.85, P = 0.000), constipation (OR = 3.96, 95% CI = 2.25-6.99, P = 0.000), dyspepsia (OR = 4.12, 95% CI = 2.63-6.45, P = 0.000), and heartburn (OR = 5.03, 95% CI 2.45-10.33, P = 0.000), while the association between migraine and NAFLD was marginally significant (OR = 2.03, 95% CI = 0.98-4.21, P = 0.055). Furthermore, the prevalence of NAFLD (OR = 2.93, 95% CI 1.29-6.65, P = 0.010) and dyspepsia (OR = 4.06, 95% CI = 2.24-7.34, P = 0.000) was significantly higher in TTH patients than the headache-free group. These findings show an association between GI disorders and primary headaches especially migraine and are, therefore, of value to the management of migraine and TTH. Further studies should investigate the etiology of the relationship between all subtypes of primary headaches and GI disorders. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/29022143/Comorbidity_of_gastrointestinal_disorders_migraine_and_tension_type_headache:_a_cross_sectional_study_in_Iran_ L2 - https://link.springer.com/10.1007/s10072-017-3141-0 DB - PRIME DP - Unbound Medicine ER -