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Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau: protective efficacy.
Lancet. 1988 Oct 08; 2(8615):809-11.Lct

Abstract

In a randomised study of 558 children in an urban African community, the protective effect of the Edmonston-Zagreb (EZ) measles vaccine given in a dose of 40,000 plaque forming units from the age of 4 months was compared with the effects of a standard dose (6000 tissue culture infectious units) of Schwarz measles vaccine given from the age of 9 months. During two years of follow-up, all 14 clinical cases of measles occurred in the Schwarz group; 10 of the children contracted measles before vaccination and 4 after measles vaccination. Thus the EZ vaccine provided significant protection against measles both before and after the usual age of vaccination. Among the children who were exposed to measles at home, those given EZ vaccine were better protected than either unvaccinated children or those given the Schwarz vaccine.

Authors+Show Affiliations

Institute of Ethnology and Anthropology, University of Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2902263

Citation

Aaby, P, et al. "Trial of High-dose Edmonston-Zagreb Measles Vaccine in Guinea-Bissau: Protective Efficacy." Lancet (London, England), vol. 2, no. 8615, 1988, pp. 809-11.
Aaby P, Jensen TG, Hansen HL, et al. Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau: protective efficacy. Lancet. 1988;2(8615):809-11.
Aaby, P., Jensen, T. G., Hansen, H. L., Kristiansen, H., Thårup, J., Poulsen, A., Sodemann, M., Jakobsen, M., Knudsen, K., & Clotilde da Silva, M. (1988). Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau: protective efficacy. Lancet (London, England), 2(8615), 809-11.
Aaby P, et al. Trial of High-dose Edmonston-Zagreb Measles Vaccine in Guinea-Bissau: Protective Efficacy. Lancet. 1988 Oct 8;2(8615):809-11. PubMed PMID: 2902263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau: protective efficacy. A1 - Aaby,P, AU - Jensen,T G, AU - Hansen,H L, AU - Kristiansen,H, AU - Thårup,J, AU - Poulsen,A, AU - Sodemann,M, AU - Jakobsen,M, AU - Knudsen,K, AU - Clotilde da Silva,M, PY - 1988/10/8/pubmed PY - 1988/10/8/medline PY - 1988/10/8/entrez KW - Africa KW - Africa South Of The Sahara KW - Age Factors KW - Child KW - Child Mortality KW - Data Collection KW - Delivery Of Health Care KW - Demographic Factors KW - Developing Countries KW - Diseases KW - Evaluation KW - Guinea-bissau KW - Health KW - Health Services KW - Immunization KW - Infections KW - Measles--prevention and control KW - Mortality KW - Population KW - Population Characteristics KW - Population Dynamics KW - Portuguese Speaking Africa KW - Primary Health Care KW - Research Methodology KW - Vaccination KW - Viral Diseases KW - Western Africa KW - Youth SP - 809 EP - 11 JF - Lancet (London, England) JO - Lancet VL - 2 IS - 8615 N2 - In a randomised study of 558 children in an urban African community, the protective effect of the Edmonston-Zagreb (EZ) measles vaccine given in a dose of 40,000 plaque forming units from the age of 4 months was compared with the effects of a standard dose (6000 tissue culture infectious units) of Schwarz measles vaccine given from the age of 9 months. During two years of follow-up, all 14 clinical cases of measles occurred in the Schwarz group; 10 of the children contracted measles before vaccination and 4 after measles vaccination. Thus the EZ vaccine provided significant protection against measles both before and after the usual age of vaccination. Among the children who were exposed to measles at home, those given EZ vaccine were better protected than either unvaccinated children or those given the Schwarz vaccine. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/2902263/Trial_of_high_dose_Edmonston_Zagreb_measles_vaccine_in_Guinea_Bissau:_protective_efficacy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(88)92780-8 DB - PRIME DP - Unbound Medicine ER -