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Review for Disease of the Year: Varicella Zoster Virus-Induced Anterior Uveitis.
Ocul Immunol Inflamm. 2018; 26(2):171-177.OI

Abstract

Varicella zoster virus (VZV)-induced anterior uveitis (AU) may complicate the course of primary varicella infection typically seen in children. In adults, especially with advanced age, VZV AU is more commonly associated with herpes zoster ophthalmicus (HZO) with or without skin rash affecting the distribution of the ophthalmic nerve due to reactivation of the latent VZV in the trigeminal ganglion. While it is typically a mild self-limiting AU in primary infection, HZO AU is often accompanied by keratitis, may have a chronic recurrent course, and lead to sectoral iris atrophy, pupillary distortion, and ocular hypertension. Diagnosis is often clinical and proven by analysis of aqueous humor for viral genome or antiviral antibodies. Systemic antiviral agents and topical steroids are the mainstay of treatment. Visual prognosis is favorable with timely diagnosis and appropriate treatment.

Authors+Show Affiliations

a Istanbul Faculty of Medicine, Department of Ophthalmology , Istanbul University , Istanbul , Turkey.b Ocular Immunology Department , Azienda Unità Sanitaria Locale di Reggio Emilia-IRCCS , Reggio Emilia , Italy.c Department of Ophthalmology , Bayindir Kavaklidere Hospital , Ankara , Turkey.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29023181

Citation

Tugal-Tutkun, Ilknur, et al. "Review for Disease of the Year: Varicella Zoster Virus-Induced Anterior Uveitis." Ocular Immunology and Inflammation, vol. 26, no. 2, 2018, pp. 171-177.
Tugal-Tutkun I, Cimino L, Akova YA. Review for Disease of the Year: Varicella Zoster Virus-Induced Anterior Uveitis. Ocul Immunol Inflamm. 2018;26(2):171-177.
Tugal-Tutkun, I., Cimino, L., & Akova, Y. A. (2018). Review for Disease of the Year: Varicella Zoster Virus-Induced Anterior Uveitis. Ocular Immunology and Inflammation, 26(2), 171-177. https://doi.org/10.1080/09273948.2017.1383447
Tugal-Tutkun I, Cimino L, Akova YA. Review for Disease of the Year: Varicella Zoster Virus-Induced Anterior Uveitis. Ocul Immunol Inflamm. 2018;26(2):171-177. PubMed PMID: 29023181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Review for Disease of the Year: Varicella Zoster Virus-Induced Anterior Uveitis. AU - Tugal-Tutkun,Ilknur, AU - Cimino,Luca, AU - Akova,Yonca Aydin, Y1 - 2017/10/12/ PY - 2017/10/13/pubmed PY - 2018/8/28/medline PY - 2017/10/13/entrez KW - Antiviral treatment KW - herpes zoster ophthalmicus KW - primary varicella infection KW - varicella zoster virus KW - viral anterior uveitis KW - visual prognosis SP - 171 EP - 177 JF - Ocular immunology and inflammation JO - Ocul. Immunol. Inflamm. VL - 26 IS - 2 N2 - Varicella zoster virus (VZV)-induced anterior uveitis (AU) may complicate the course of primary varicella infection typically seen in children. In adults, especially with advanced age, VZV AU is more commonly associated with herpes zoster ophthalmicus (HZO) with or without skin rash affecting the distribution of the ophthalmic nerve due to reactivation of the latent VZV in the trigeminal ganglion. While it is typically a mild self-limiting AU in primary infection, HZO AU is often accompanied by keratitis, may have a chronic recurrent course, and lead to sectoral iris atrophy, pupillary distortion, and ocular hypertension. Diagnosis is often clinical and proven by analysis of aqueous humor for viral genome or antiviral antibodies. Systemic antiviral agents and topical steroids are the mainstay of treatment. Visual prognosis is favorable with timely diagnosis and appropriate treatment. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/29023181/Review_for_Disease_of_the_Year:_Varicella_Zoster_Virus_Induced_Anterior_Uveitis_ L2 - http://www.tandfonline.com/doi/full/10.1080/09273948.2017.1383447 DB - PRIME DP - Unbound Medicine ER -