Tags

Type your tag names separated by a space and hit enter

Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface.
Am J Physiol Gastrointest Liver Physiol. 2018 02 01; 314(2):G143-G149.AJ

Abstract

A diverse range of effects of the intestinal microbiota on mucosal defense and injury has become increasingly clear over the past decade. Hydrogen sulfide (H2S) has emerged as an important mediator of many physiological functions, including gastrointestinal mucosal defense and repair. Hydrogen sulfide is produced by gastrointestinal tract tissues and by bacteria residing within the gut and can influence the function of a wide range of cells. The microbiota also appears to be an important target of hydrogen sulfide. H2S donors can modify the gut microbiota, and the gastrointestinal epithelium is a major site of oxidation of microbial-derived H2S. When administered together with nonsteroidal anti-inflammatory drugs, H2S can prevent some of the dysbiosis those drugs induce, possibly contributing to the observed prevention of gastrointestinal damage. Exogenous H2S can also markedly reduce the severity of experimental colitis and plays important roles in modulating epithelial cell-mucus-bacterial interactions in the intestine, contributing to its ability to promote resolution of inflammation and repair of tissue injury. In this paper we review recent studies examining the roles of H2S in mucosal defense, the possibility that H2S can damage the gastrointestinal epithelium, and effects of H2S on the gut microbiota and on mucus and biofilm interactions in the context of intestinal inflammation.

Authors+Show Affiliations

Department of Physiology and Pharmacology, University of Calgary , Calgary, Alberta , Canada. Faculty of Medicine, Universidade Camilo Castelo Branco, Fernandópolis, Brazil.Institut de Recherche en Santé Digestive, Université de Toulouse , Toulouse , France. Institut National de la Santé et de la Recherche Médicale, Institut National de la Recherche Agronomique, Ecole Nationale Vétérinaire de Toulouse, Université Paul Sabatier , Toulouse , France. Department of Biological Sciences, University of Calgary , Calgary, Alberta , Canada.Department of Biological Sciences, University of Calgary , Calgary, Alberta , Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

29025733

Citation

Wallace, John L., et al. "Hydrogen Sulfide: an Agent of Stability at the Microbiome-mucosa Interface." American Journal of Physiology. Gastrointestinal and Liver Physiology, vol. 314, no. 2, 2018, pp. G143-G149.
Wallace JL, Motta JP, Buret AG. Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface. Am J Physiol Gastrointest Liver Physiol. 2018;314(2):G143-G149.
Wallace, J. L., Motta, J. P., & Buret, A. G. (2018). Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface. American Journal of Physiology. Gastrointestinal and Liver Physiology, 314(2), G143-G149. https://doi.org/10.1152/ajpgi.00249.2017
Wallace JL, Motta JP, Buret AG. Hydrogen Sulfide: an Agent of Stability at the Microbiome-mucosa Interface. Am J Physiol Gastrointest Liver Physiol. 2018 02 1;314(2):G143-G149. PubMed PMID: 29025733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface. AU - Wallace,John L, AU - Motta,Jean-Paul, AU - Buret,Andre G, Y1 - 2017/10/12/ PY - 2017/10/14/pubmed PY - 2019/2/27/medline PY - 2017/10/14/entrez KW - NSAID KW - bacteria KW - biofilm KW - colitis KW - epithelium KW - inflammatory bowel disease KW - intestine KW - microbiota KW - mucus SP - G143 EP - G149 JF - American journal of physiology. Gastrointestinal and liver physiology JO - Am. J. Physiol. Gastrointest. Liver Physiol. VL - 314 IS - 2 N2 - A diverse range of effects of the intestinal microbiota on mucosal defense and injury has become increasingly clear over the past decade. Hydrogen sulfide (H2S) has emerged as an important mediator of many physiological functions, including gastrointestinal mucosal defense and repair. Hydrogen sulfide is produced by gastrointestinal tract tissues and by bacteria residing within the gut and can influence the function of a wide range of cells. The microbiota also appears to be an important target of hydrogen sulfide. H2S donors can modify the gut microbiota, and the gastrointestinal epithelium is a major site of oxidation of microbial-derived H2S. When administered together with nonsteroidal anti-inflammatory drugs, H2S can prevent some of the dysbiosis those drugs induce, possibly contributing to the observed prevention of gastrointestinal damage. Exogenous H2S can also markedly reduce the severity of experimental colitis and plays important roles in modulating epithelial cell-mucus-bacterial interactions in the intestine, contributing to its ability to promote resolution of inflammation and repair of tissue injury. In this paper we review recent studies examining the roles of H2S in mucosal defense, the possibility that H2S can damage the gastrointestinal epithelium, and effects of H2S on the gut microbiota and on mucus and biofilm interactions in the context of intestinal inflammation. SN - 1522-1547 UR - https://www.unboundmedicine.com/medline/citation/29025733/Hydrogen_sulfide:_an_agent_of_stability_at_the_microbiome_mucosa_interface_ L2 - http://journals.physiology.org/doi/full/10.1152/ajpgi.00249.2017?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -