Tags

Type your tag names separated by a space and hit enter

Porous Se@SiO2 nanospheres treated paraquat-induced acute lung injury by resisting oxidative stress.
Int J Nanomedicine. 2017; 12:7143-7152.IJ

Abstract

Acute paraquat (PQ) poisoning is one of the most common forms of pesticide poisoning. Oxidative stress and inflammation are thought to be important mechanisms in PQ-induced acute lung injury (ALI). Selenium (Se) can scavenge intracellular free radicals directly or indirectly. In this study, we investigated whether porous Se@SiO2 nanospheres could alleviate oxidative stress and inflammation in PQ-induced ALI. Male Sprague Dawley rats and RLE-6TN cells were used in this study. Rats were categorized into 3 groups: control (n=6), PQ (n=18), and PQ + Se@SiO2 (n=18). The PQ and PQ + Se@SiO2 groups were randomly and evenly divided into 3 sub-groups according to different time points (24, 48 and 72 h) after PQ treatment. Porous Se@SiO2 nanospheres 1 mg/kg (in the PQ + Se@SiO2 group) were administered via intraperitoneal injection every 24 h. Expression levels of reduced glutathione, malondialdehyde, superoxide dismutase, reactive oxygen species (ROS), nuclear factor-κB (NF-κB), phosphorylated NF-κB (p-NF-κB), tumor necrosis factor-α and interleukin-1β were detected, and a histological analysis of rat lung tissues was performed. The results showed that the levels of ROS, malondialdehyde, NF-κB, p-NF-κB, tumor necrosis factor-α and interleukin-1β were markedly increased after PQ treatment. Glutathione and superoxide dismutase levels were reduced. However, treatment with porous Se@SiO2 nanospheres markedly alleviated PQ-induced oxidative stress and inflammation. Additionally, the results from histological examinations and wet-to-dry weight ratios of rat lung tissues showed that lung damage was reduced after porous Se@SiO2 nanosphere treatment. These data indicate that porous Se@SiO2 nanospheres may reduce NF-κB, p-NF-κB and inflammatory cytokine levels by inhibiting ROS in PQ-induced ALI. This study demonstrates that porous Se@SiO2 nanospheres may be a therapeutic method for use in the future for PQ poisoning.

Authors+Show Affiliations

Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine.Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine.Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine.Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine.Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29026307

Citation

Zhu, Yong, et al. "Porous Se@SiO2 Nanospheres Treated Paraquat-induced Acute Lung Injury By Resisting Oxidative Stress." International Journal of Nanomedicine, vol. 12, 2017, pp. 7143-7152.
Zhu Y, Deng G, Ji A, et al. Porous Se@SiO2 nanospheres treated paraquat-induced acute lung injury by resisting oxidative stress. Int J Nanomedicine. 2017;12:7143-7152.
Zhu, Y., Deng, G., Ji, A., Yao, J., Meng, X., Wang, J., Wang, Q., Wang, Q., & Wang, R. (2017). Porous Se@SiO2 nanospheres treated paraquat-induced acute lung injury by resisting oxidative stress. International Journal of Nanomedicine, 12, 7143-7152. https://doi.org/10.2147/IJN.S143192
Zhu Y, et al. Porous Se@SiO2 Nanospheres Treated Paraquat-induced Acute Lung Injury By Resisting Oxidative Stress. Int J Nanomedicine. 2017;12:7143-7152. PubMed PMID: 29026307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Porous Se@SiO2 nanospheres treated paraquat-induced acute lung injury by resisting oxidative stress. AU - Zhu,Yong, AU - Deng,Guoying, AU - Ji,Anqi, AU - Yao,Jiayi, AU - Meng,Xiaoxiao, AU - Wang,Jinfeng, AU - Wang,Qian, AU - Wang,Qiugen, AU - Wang,Ruilan, Y1 - 2017/09/27/ PY - 2017/10/14/entrez PY - 2017/10/14/pubmed PY - 2018/1/16/medline KW - NF-kappa B KW - ROS KW - acute lung injury KW - inflammatory cytokines KW - oxidative stress KW - paraquat poisoning KW - porous Se@SiO2 nanospheres SP - 7143 EP - 7152 JF - International journal of nanomedicine JO - Int J Nanomedicine VL - 12 N2 - Acute paraquat (PQ) poisoning is one of the most common forms of pesticide poisoning. Oxidative stress and inflammation are thought to be important mechanisms in PQ-induced acute lung injury (ALI). Selenium (Se) can scavenge intracellular free radicals directly or indirectly. In this study, we investigated whether porous Se@SiO2 nanospheres could alleviate oxidative stress and inflammation in PQ-induced ALI. Male Sprague Dawley rats and RLE-6TN cells were used in this study. Rats were categorized into 3 groups: control (n=6), PQ (n=18), and PQ + Se@SiO2 (n=18). The PQ and PQ + Se@SiO2 groups were randomly and evenly divided into 3 sub-groups according to different time points (24, 48 and 72 h) after PQ treatment. Porous Se@SiO2 nanospheres 1 mg/kg (in the PQ + Se@SiO2 group) were administered via intraperitoneal injection every 24 h. Expression levels of reduced glutathione, malondialdehyde, superoxide dismutase, reactive oxygen species (ROS), nuclear factor-κB (NF-κB), phosphorylated NF-κB (p-NF-κB), tumor necrosis factor-α and interleukin-1β were detected, and a histological analysis of rat lung tissues was performed. The results showed that the levels of ROS, malondialdehyde, NF-κB, p-NF-κB, tumor necrosis factor-α and interleukin-1β were markedly increased after PQ treatment. Glutathione and superoxide dismutase levels were reduced. However, treatment with porous Se@SiO2 nanospheres markedly alleviated PQ-induced oxidative stress and inflammation. Additionally, the results from histological examinations and wet-to-dry weight ratios of rat lung tissues showed that lung damage was reduced after porous Se@SiO2 nanosphere treatment. These data indicate that porous Se@SiO2 nanospheres may reduce NF-κB, p-NF-κB and inflammatory cytokine levels by inhibiting ROS in PQ-induced ALI. This study demonstrates that porous Se@SiO2 nanospheres may be a therapeutic method for use in the future for PQ poisoning. SN - 1178-2013 UR - https://www.unboundmedicine.com/medline/citation/29026307/Porous_Se@SiO2_nanospheres_treated_paraquat_induced_acute_lung_injury_by_resisting_oxidative_stress_ L2 - https://dx.doi.org/10.2147/IJN.S143192 DB - PRIME DP - Unbound Medicine ER -