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Impact of Three Doses of Vitamin D3 on Serum 25(OH)D Deficiency and Insufficiency in At-Risk Schoolchildren.
J Clin Endocrinol Metab. 2017 12 01; 102(12):4496-4505.JC

Abstract

Objective

We investigated the daily dose of vitamin D needed to achieve serum 25-hydroxyvitamin D [25(OH)D] sufficiency among schoolchildren at risk for deficiency.

Study Design

The Daily D Health Study was a randomized double-blind vitamin D supplementation trial among racially/ethnically diverse schoolchildren (n = 685) in the northeastern United States. Children were supplemented with vitamin D3 at 600, 1000, or 2000 IU/d for 6 months. Measurements included serum 25(OH)D at baseline (October to December), 3 months (January to March), 6 months (April to June), and 12 months (6 months after supplementation).

Results

At baseline, mean ± standard deviation serum 25(OH)D level was 22.0 ± 6.8 ng/mL, with 5.5% severely vitamin D deficient (<12 ng/mL), 34.1% deficient (12 to 19 ng/mL), 49.0% insufficient (20 to 29 ng/mL), and 11.4% sufficient (≥30 ng/mL). The lowest levels of serum 25(OH)D were found among black (17.9 ± 6.7 ng/mL) and Asian children (18.9 ± 4.8 ng/mL), with no baseline differences by weight status. Serum 25(OH)D increased over 6 months in all three dose groups. The 2000 IU/d group achieved a higher mean serum 25(OH)D level than the other two dose groups (33.1 vs 26.3 and 27.5 ng/mL; P < 0.001), with 59.9% of this group attaining sufficiency at 3 months and only 5.3% remaining severely deficient/deficient at 6 months. All dose groups demonstrated a fall in 25(OH)D at 12 months.

Conclusions

Children at risk for vitamin D deficiency benefited from daily sustained supplementation of 2000 IU/d compared with lower doses closer to the current recommended daily allowance for vitamin D intake. This benefit occurred over the winter months, when serum 25(OH)D level tend to fall.

Authors+Show Affiliations

Friedman School of Nutrition Science and Policy, Tufts University.Friedman School of Nutrition Science and Policy, Tufts University.Tufts University School of Medicine.Friedman School of Nutrition Science and Policy, Tufts University.Tufts University School of Medicine.Harvard Medical School.University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center.Boston University School of Medicine.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29029097

Citation

Sacheck, Jennifer M., et al. "Impact of Three Doses of Vitamin D3 On Serum 25(OH)D Deficiency and Insufficiency in At-Risk Schoolchildren." The Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 12, 2017, pp. 4496-4505.
Sacheck JM, Van Rompay MI, Chomitz VR, et al. Impact of Three Doses of Vitamin D3 on Serum 25(OH)D Deficiency and Insufficiency in At-Risk Schoolchildren. J Clin Endocrinol Metab. 2017;102(12):4496-4505.
Sacheck, J. M., Van Rompay, M. I., Chomitz, V. R., Economos, C. D., Eliasziw, M., Goodman, E., Gordon, C. M., & Holick, M. F. (2017). Impact of Three Doses of Vitamin D3 on Serum 25(OH)D Deficiency and Insufficiency in At-Risk Schoolchildren. The Journal of Clinical Endocrinology and Metabolism, 102(12), 4496-4505. https://doi.org/10.1210/jc.2017-01179
Sacheck JM, et al. Impact of Three Doses of Vitamin D3 On Serum 25(OH)D Deficiency and Insufficiency in At-Risk Schoolchildren. J Clin Endocrinol Metab. 2017 12 1;102(12):4496-4505. PubMed PMID: 29029097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of Three Doses of Vitamin D3 on Serum 25(OH)D Deficiency and Insufficiency in At-Risk Schoolchildren. AU - Sacheck,Jennifer M, AU - Van Rompay,Maria I, AU - Chomitz,Virginia R, AU - Economos,Christina D, AU - Eliasziw,Misha, AU - Goodman,Elizabeth, AU - Gordon,Catherine M, AU - Holick,Michael F, PY - 2017/05/23/received PY - 2017/09/14/accepted PY - 2017/10/14/pubmed PY - 2017/12/15/medline PY - 2017/10/14/entrez SP - 4496 EP - 4505 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 102 IS - 12 N2 - Objective: We investigated the daily dose of vitamin D needed to achieve serum 25-hydroxyvitamin D [25(OH)D] sufficiency among schoolchildren at risk for deficiency. Study Design: The Daily D Health Study was a randomized double-blind vitamin D supplementation trial among racially/ethnically diverse schoolchildren (n = 685) in the northeastern United States. Children were supplemented with vitamin D3 at 600, 1000, or 2000 IU/d for 6 months. Measurements included serum 25(OH)D at baseline (October to December), 3 months (January to March), 6 months (April to June), and 12 months (6 months after supplementation). Results: At baseline, mean ± standard deviation serum 25(OH)D level was 22.0 ± 6.8 ng/mL, with 5.5% severely vitamin D deficient (<12 ng/mL), 34.1% deficient (12 to 19 ng/mL), 49.0% insufficient (20 to 29 ng/mL), and 11.4% sufficient (≥30 ng/mL). The lowest levels of serum 25(OH)D were found among black (17.9 ± 6.7 ng/mL) and Asian children (18.9 ± 4.8 ng/mL), with no baseline differences by weight status. Serum 25(OH)D increased over 6 months in all three dose groups. The 2000 IU/d group achieved a higher mean serum 25(OH)D level than the other two dose groups (33.1 vs 26.3 and 27.5 ng/mL; P < 0.001), with 59.9% of this group attaining sufficiency at 3 months and only 5.3% remaining severely deficient/deficient at 6 months. All dose groups demonstrated a fall in 25(OH)D at 12 months. Conclusions: Children at risk for vitamin D deficiency benefited from daily sustained supplementation of 2000 IU/d compared with lower doses closer to the current recommended daily allowance for vitamin D intake. This benefit occurred over the winter months, when serum 25(OH)D level tend to fall. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/29029097/Impact_of_Three_Doses_of_Vitamin_D3_on_Serum_25_OH_D_Deficiency_and_Insufficiency_in_At_Risk_Schoolchildren_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2017-01179 DB - PRIME DP - Unbound Medicine ER -