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Limited effect of adaptive immune response to control encephalitozoonosis.
Parasite Immunol. 2017 Dec; 39(12)PI

Abstract

This study revises our understanding of the effectiveness of cell-mediated adaptive immunity and treatment against microsporidia using molecular detection and quantification of microsporidia in immunocompetent C57Bl/6 and immunodeficient CD4-/- and CD8-/- mice for the first time. We demonstrate an intense dissemination of microsporidia into most organs within the first weeks post-infection in all strains of mice, followed by a chronic infection characterized by microsporidia persistence in CD4-/- and C57Bl/6 mice and a lethal outcome for CD8-/- mice. Albendazole application reduces microsporidia burden in C57Bl/6 and CD4-/- mice, whereas CD8-/- mice experience only a temporary effect of the treatment. Surprisingly, treated CD8-/- mice survived the entire experimental duration despite enormous microsporidia burden. On the basis of our results, we conclude that microsporidia survive despite the presence of immune mechanisms and treatments that are currently considered to be effective and therefore that CD8 T lymphocytes represent a major, but not sole effector mechanism controlling microsporidiosis. Furthermore, the survival of mice does not correspond to spore burden, which provides new insight into latent microsporidiosis from an epidemiological point of view.

Authors+Show Affiliations

Institute of Parasitology, BC CAS, v.v.i., České Budějovice, Czech Republic.Faculty of Agriculture, University of South Bohemia in České Budějovice, České Budějovice, Czech Republic.Institute of Parasitology, BC CAS, v.v.i., České Budějovice, Czech Republic.Institute of Parasitology, BC CAS, v.v.i., České Budějovice, Czech Republic. Faculty of Agriculture, University of South Bohemia in České Budějovice, České Budějovice, Czech Republic.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29032596

Citation

Sak, B, et al. "Limited Effect of Adaptive Immune Response to Control Encephalitozoonosis." Parasite Immunology, vol. 39, no. 12, 2017.
Sak B, Kotková M, Hlásková L, et al. Limited effect of adaptive immune response to control encephalitozoonosis. Parasite Immunol. 2017;39(12).
Sak, B., Kotková, M., Hlásková, L., & Kváč, M. (2017). Limited effect of adaptive immune response to control encephalitozoonosis. Parasite Immunology, 39(12). https://doi.org/10.1111/pim.12496
Sak B, et al. Limited Effect of Adaptive Immune Response to Control Encephalitozoonosis. Parasite Immunol. 2017;39(12) PubMed PMID: 29032596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Limited effect of adaptive immune response to control encephalitozoonosis. AU - Sak,B, AU - Kotková,M, AU - Hlásková,L, AU - Kváč,M, Y1 - 2017/11/01/ PY - 2017/02/09/received PY - 2017/10/11/accepted PY - 2017/10/17/pubmed PY - 2018/3/14/medline PY - 2017/10/17/entrez KW - CD4 T lymphocytes KW - Cell, CD8+ T lymphocytes KW - Cell, Encephalitozoon cuniculi KW - Parasite JF - Parasite immunology JO - Parasite Immunol. VL - 39 IS - 12 N2 - This study revises our understanding of the effectiveness of cell-mediated adaptive immunity and treatment against microsporidia using molecular detection and quantification of microsporidia in immunocompetent C57Bl/6 and immunodeficient CD4-/- and CD8-/- mice for the first time. We demonstrate an intense dissemination of microsporidia into most organs within the first weeks post-infection in all strains of mice, followed by a chronic infection characterized by microsporidia persistence in CD4-/- and C57Bl/6 mice and a lethal outcome for CD8-/- mice. Albendazole application reduces microsporidia burden in C57Bl/6 and CD4-/- mice, whereas CD8-/- mice experience only a temporary effect of the treatment. Surprisingly, treated CD8-/- mice survived the entire experimental duration despite enormous microsporidia burden. On the basis of our results, we conclude that microsporidia survive despite the presence of immune mechanisms and treatments that are currently considered to be effective and therefore that CD8 T lymphocytes represent a major, but not sole effector mechanism controlling microsporidiosis. Furthermore, the survival of mice does not correspond to spore burden, which provides new insight into latent microsporidiosis from an epidemiological point of view. SN - 1365-3024 UR - https://www.unboundmedicine.com/medline/citation/29032596/Limited_effect_of_adaptive_immune_response_to_control_encephalitozoonosis_ L2 - https://doi.org/10.1111/pim.12496 DB - PRIME DP - Unbound Medicine ER -