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Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro.
Neurosci Lett. 1988 Sep 23; 92(1):64-8.NL

Abstract

Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 2-5 microM) reversibly blocked the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow gamma-aminobutyric acid (GABA)-mediated inhibition. Membrane potential, input resistance and spike accommodation were not altered. Inward currents induced by quisqualate were reduced to a greater extent by CNQX than those induced by kainate or N-methyl-D-aspartate. We suggest that CNQX may be a useful antagonist to study excitatory amino acid-mediated synaptic transmission.

Authors+Show Affiliations

INSERM U29, Hôpital de Port-Royal, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2903471

Citation

Neuman, R S., et al. "Blockade of Excitatory Synaptic Transmission By 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the Hippocampus in Vitro." Neuroscience Letters, vol. 92, no. 1, 1988, pp. 64-8.
Neuman RS, Ben-Ari Y, Gho M, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro. Neurosci Lett. 1988;92(1):64-8.
Neuman, R. S., Ben-Ari, Y., Gho, M., & Cherubini, E. (1988). Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro. Neuroscience Letters, 92(1), 64-8.
Neuman RS, et al. Blockade of Excitatory Synaptic Transmission By 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the Hippocampus in Vitro. Neurosci Lett. 1988 Sep 23;92(1):64-8. PubMed PMID: 2903471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro. AU - Neuman,R S, AU - Ben-Ari,Y, AU - Gho,M, AU - Cherubini,E, PY - 1988/9/23/pubmed PY - 1988/9/23/medline PY - 1988/9/23/entrez SP - 64 EP - 8 JF - Neuroscience letters JO - Neurosci Lett VL - 92 IS - 1 N2 - Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 2-5 microM) reversibly blocked the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow gamma-aminobutyric acid (GABA)-mediated inhibition. Membrane potential, input resistance and spike accommodation were not altered. Inward currents induced by quisqualate were reduced to a greater extent by CNQX than those induced by kainate or N-methyl-D-aspartate. We suggest that CNQX may be a useful antagonist to study excitatory amino acid-mediated synaptic transmission. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/2903471/Blockade_of_excitatory_synaptic_transmission_by_6_cyano_7_nitroquinoxaline_23_dione__CNQX__in_the_hippocampus_in_vitro_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0304-3940(88)90743-4 DB - PRIME DP - Unbound Medicine ER -