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Effect of basic fibroblast growth factor on radiation-induced oral mucositis in male Syrian hamsters.
Int J Radiat Biol 2017; 93(12):1343-1349IJ

Abstract

PURPOSE

Oral mucositis is a frequent and dose-limiting side effect of radiotherapy or chemotherapy in cancer patients. We investigated the effect of basic fibroblast growth factor on radiation-induced oral mucositis in male Syrian hamsters.

METHOD

Oral mucositis was induced in male Syrian hamsters by a single dose of 30-Gy irradiation. Eight days after irradiation, treatment with gel containing trafermin (basic fibroblast growth factor) at 1 or 10 μg up to day-21 was initiated. Re-epithelialization was graded using a six-point scoring system for oral mucositis. Samples of hamster cheek pouches were removed for histopathologic analyses and immunohistochemistry.

RESULTS

The oral-mucositis score decreased in a dose-dependent manner upon trafermin treatment. Trafermin (10 μg) improved oral mucositis significantly compared with vehicle. Histopathology revealed that the degree of re-epithelialization was improved by treatment with trafermin (10 μg) compared with treatment with vehicle.

CONCLUSIONS

Administration of trafermin (10 μg) can prevent mucosal damage to hamster cheek pouches induced by irradiation.

Authors+Show Affiliations

a Division of Pharmacy , Ehime University Hospital , Toon , Japan.a Division of Pharmacy , Ehime University Hospital , Toon , Japan.a Division of Pharmacy , Ehime University Hospital , Toon , Japan.a Division of Pharmacy , Ehime University Hospital , Toon , Japan.a Division of Pharmacy , Ehime University Hospital , Toon , Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29034752

Citation

Sumikawa, Satomi, et al. "Effect of Basic Fibroblast Growth Factor On Radiation-induced Oral Mucositis in Male Syrian Hamsters." International Journal of Radiation Biology, vol. 93, no. 12, 2017, pp. 1343-1349.
Sumikawa S, Watanabe S, Tanaka M, et al. Effect of basic fibroblast growth factor on radiation-induced oral mucositis in male Syrian hamsters. Int J Radiat Biol. 2017;93(12):1343-1349.
Sumikawa, S., Watanabe, S., Tanaka, M., Tanaka, A., & Araki, H. (2017). Effect of basic fibroblast growth factor on radiation-induced oral mucositis in male Syrian hamsters. International Journal of Radiation Biology, 93(12), pp. 1343-1349. doi:10.1080/09553002.2017.1393578.
Sumikawa S, et al. Effect of Basic Fibroblast Growth Factor On Radiation-induced Oral Mucositis in Male Syrian Hamsters. Int J Radiat Biol. 2017;93(12):1343-1349. PubMed PMID: 29034752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of basic fibroblast growth factor on radiation-induced oral mucositis in male Syrian hamsters. AU - Sumikawa,Satomi, AU - Watanabe,Shinichi, AU - Tanaka,Mamoru, AU - Tanaka,Akihiro, AU - Araki,Hiroaki, Y1 - 2017/11/06/ PY - 2017/10/17/pubmed PY - 2017/12/12/medline PY - 2017/10/17/entrez KW - Oral mucositis KW - hamster KW - irradiation KW - trafermin SP - 1343 EP - 1349 JF - International journal of radiation biology JO - Int. J. Radiat. Biol. VL - 93 IS - 12 N2 - PURPOSE: Oral mucositis is a frequent and dose-limiting side effect of radiotherapy or chemotherapy in cancer patients. We investigated the effect of basic fibroblast growth factor on radiation-induced oral mucositis in male Syrian hamsters. METHOD: Oral mucositis was induced in male Syrian hamsters by a single dose of 30-Gy irradiation. Eight days after irradiation, treatment with gel containing trafermin (basic fibroblast growth factor) at 1 or 10 μg up to day-21 was initiated. Re-epithelialization was graded using a six-point scoring system for oral mucositis. Samples of hamster cheek pouches were removed for histopathologic analyses and immunohistochemistry. RESULTS: The oral-mucositis score decreased in a dose-dependent manner upon trafermin treatment. Trafermin (10 μg) improved oral mucositis significantly compared with vehicle. Histopathology revealed that the degree of re-epithelialization was improved by treatment with trafermin (10 μg) compared with treatment with vehicle. CONCLUSIONS: Administration of trafermin (10 μg) can prevent mucosal damage to hamster cheek pouches induced by irradiation. SN - 1362-3095 UR - https://www.unboundmedicine.com/medline/citation/29034752/Effect_of_basic_fibroblast_growth_factor_on_radiation_induced_oral_mucositis_in_male_Syrian_hamsters_ L2 - http://www.tandfonline.com/doi/full/10.1080/09553002.2017.1393578 DB - PRIME DP - Unbound Medicine ER -