Citation
Reijs, Babette L R., et al. "Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: a Longitudinal Descriptive Cohort Study." Journal of Alzheimer's Disease : JAD, vol. 60, no. 4, 2017, pp. 1387-1395.
Reijs BLR, Vos SJB, Soininen H, et al. Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study. J Alzheimers Dis. 2017;60(4):1387-1395.
Reijs, B. L. R., Vos, S. J. B., Soininen, H., Lötjonen, J., Koikkalainen, J., Pikkarainen, M., Hall, A., Vanninen, R., Liu, Y., Herukka, S. K., Freund-Levi, Y., Frisoni, G. B., Frölich, L., Nobili, F., Rikkert, M. O., Spiru, L., Tsolaki, M., Wallin, Å. K., Scheltens, P., ... Visser, P. J. (2017). Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study. Journal of Alzheimer's Disease : JAD, 60(4), 1387-1395. https://doi.org/10.3233/JAD-170039
Reijs BLR, et al. Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: a Longitudinal Descriptive Cohort Study. J Alzheimers Dis. 2017;60(4):1387-1395. PubMed PMID: 29036813.
TY - JOUR
T1 - Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study.
AU - Reijs,Babette L R,
AU - Vos,Stephanie J B,
AU - Soininen,Hilkka,
AU - Lötjonen,Jyrki,
AU - Koikkalainen,Juha,
AU - Pikkarainen,Maria,
AU - Hall,Anette,
AU - Vanninen,Ritva,
AU - Liu,Yawu,
AU - Herukka,Sanna-Kaisa,
AU - Freund-Levi,Yvonne,
AU - Frisoni,Giovanni B,
AU - Frölich,Lutz,
AU - Nobili,Flavio,
AU - Rikkert,Marcel Olde,
AU - Spiru,Luiza,
AU - Tsolaki,Magda,
AU - Wallin,Åsa K,
AU - Scheltens,Philip,
AU - Verhey,Frans,
AU - Visser,Pieter Jelle,
PY - 2017/10/19/pubmed
PY - 2018/7/24/medline
PY - 2017/10/18/entrez
KW - Alcohol consumption
KW - Alzheimer’s disease
KW - amyloid-β (1–42)
KW - cerebrospinal fluid
KW - cognitive reserve
KW - exercise
KW - hippocampus
KW - lifestyle
KW - mild cognitive impairment
SP - 1387
EP - 1395
JF - Journal of Alzheimer's disease : JAD
JO - J Alzheimers Dis
VL - 60
IS - 4
N2 - BACKGROUND: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear. OBJECTIVE: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-β 1-42 (Aβ42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI. METHODS: We selected individuals with SCD (n = 111) and MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal MCI studies. CSF Aβ42 and tau concentrations were assessed with ELISA assay and hippocampal volume with multi-atlas segmentation. Lifestyle was assessed by clinical interview at baseline for: social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep. We performed logistic and Cox regression analyses adjusted for study site, age, gender, education, and diagnosis. Prediction for AD-type dementia was performed in individuals with MCI only. RESULTS: Later life lifestyle factors were not associated with AD biomarkers or with conversion to AD-type dementia. AD biomarkers were strongly associated with conversion to AD-type dementia, but these relations were not modulated by lifestyle factors. Apolipoprotein E (APOE) genotype did not influence the results. CONCLUSIONS: Later life lifestyle factors had no impact on key AD biomarkers in individuals with SCD and MCI or on conversion to AD-type dementia in MCI.
SN - 1875-8908
UR - https://www.unboundmedicine.com/medline/citation/29036813/Association_Between_Later_Life_Lifestyle_Factors_and_Alzheimer's_Disease_Biomarkers_in_Non_Demented_Individuals:_A_Longitudinal_Descriptive_Cohort_Study_
DB - PRIME
DP - Unbound Medicine
ER -