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Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study.
J Alzheimers Dis 2017; 60(4):1387-1395JA

Abstract

BACKGROUND

Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear.

OBJECTIVE

To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-β 1-42 (Aβ42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI.

METHODS

We selected individuals with SCD (n = 111) and MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal MCI studies. CSF Aβ42 and tau concentrations were assessed with ELISA assay and hippocampal volume with multi-atlas segmentation. Lifestyle was assessed by clinical interview at baseline for: social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep. We performed logistic and Cox regression analyses adjusted for study site, age, gender, education, and diagnosis. Prediction for AD-type dementia was performed in individuals with MCI only.

RESULTS

Later life lifestyle factors were not associated with AD biomarkers or with conversion to AD-type dementia. AD biomarkers were strongly associated with conversion to AD-type dementia, but these relations were not modulated by lifestyle factors. Apolipoprotein E (APOE) genotype did not influence the results.

CONCLUSIONS

Later life lifestyle factors had no impact on key AD biomarkers in individuals with SCD and MCI or on conversion to AD-type dementia in MCI.

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    • Authors+Show Affiliations

    Reijs BLR
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.
    Vos SJB
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.
    Soininen H
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland. Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
    Lötjonen J
    VTT Technical Research Centre of Finland, Tampere, Finland. Combinostics Oy, Tampere, Finland.
    Koikkalainen J
    VTT Technical Research Centre of Finland, Tampere, Finland. Combinostics Oy, Tampere, Finland.
    Pikkarainen M
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland.
    Hall A
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland.
    Vanninen R
    Department of Radiology, Kuopio University Hospital, Kuopio, Finland.
    Liu Y
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland. Department of Radiology, Kuopio University Hospital, Kuopio, Finland.
    Herukka SK
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland. Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
    Freund-Levi Y
    Department of NVS, Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.
    Frisoni GB
    LENITEM, IRCCS Fatebenefratelli, Brescia.
    Frölich L
    Department of Geriatric Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Germany.
    Nobili F
    Department of Neuroscience (DINOGMI), Clinical Neurology, University of Genoa and IRCCS AOU San Martino-IST Genoa, Italy.
    Rikkert MO
    Department of Geriatrics, Radboud University Medical Centre, Nijmegen, The Netherlands.
    Spiru L
    Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.
    Tsolaki M
    Aristotle University of Thessaloniki, Memory and Dementia Centre, G. Papanicolaore General Hospital, Thessaloniki, Greece.
    Wallin ÅK
    Department of Clinical Sciences Malmö, Clinical Memory Research Unit, Lund University, Sweden.
    Scheltens P
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.
    Verhey F
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.
    Visser PJ
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands. Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.

    MeSH

    Age FactorsAgedAlcohol DrinkingAlzheimer DiseaseApolipoproteins ECognitionCognition DisordersDiagnostic Self EvaluationDisease ProgressionEducational StatusExerciseFemaleFollow-Up StudiesHippocampusHumansLife StyleLongitudinal StudiesMaleOrgan SizeSex FactorsSleepSmokingSocial Behavior

    Pub Type(s)

    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    29036813

    Citation

    Reijs, Babette L R., et al. "Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: a Longitudinal Descriptive Cohort Study." Journal of Alzheimer's Disease : JAD, vol. 60, no. 4, 2017, pp. 1387-1395.
    Reijs BLR, Vos SJB, Soininen H, et al. Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study. J Alzheimers Dis. 2017;60(4):1387-1395.
    Reijs, B. L. R., Vos, S. J. B., Soininen, H., Lötjonen, J., Koikkalainen, J., Pikkarainen, M., ... Visser, P. J. (2017). Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study. Journal of Alzheimer's Disease : JAD, 60(4), pp. 1387-1395. doi:10.3233/JAD-170039.
    Reijs BLR, et al. Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: a Longitudinal Descriptive Cohort Study. J Alzheimers Dis. 2017;60(4):1387-1395. PubMed PMID: 29036813.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study. AU - Reijs,Babette L R, AU - Vos,Stephanie J B, AU - Soininen,Hilkka, AU - Lötjonen,Jyrki, AU - Koikkalainen,Juha, AU - Pikkarainen,Maria, AU - Hall,Anette, AU - Vanninen,Ritva, AU - Liu,Yawu, AU - Herukka,Sanna-Kaisa, AU - Freund-Levi,Yvonne, AU - Frisoni,Giovanni B, AU - Frölich,Lutz, AU - Nobili,Flavio, AU - Rikkert,Marcel Olde, AU - Spiru,Luiza, AU - Tsolaki,Magda, AU - Wallin,Åsa K, AU - Scheltens,Philip, AU - Verhey,Frans, AU - Visser,Pieter Jelle, PY - 2017/10/19/pubmed PY - 2018/7/24/medline PY - 2017/10/18/entrez KW - Alcohol consumption KW - Alzheimer’s disease KW - amyloid-β (1–42) KW - cerebrospinal fluid KW - cognitive reserve KW - exercise KW - hippocampus KW - lifestyle KW - mild cognitive impairment SP - 1387 EP - 1395 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 60 IS - 4 N2 - BACKGROUND: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear. OBJECTIVE: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-β 1-42 (Aβ42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI. METHODS: We selected individuals with SCD (n = 111) and MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal MCI studies. CSF Aβ42 and tau concentrations were assessed with ELISA assay and hippocampal volume with multi-atlas segmentation. Lifestyle was assessed by clinical interview at baseline for: social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep. We performed logistic and Cox regression analyses adjusted for study site, age, gender, education, and diagnosis. Prediction for AD-type dementia was performed in individuals with MCI only. RESULTS: Later life lifestyle factors were not associated with AD biomarkers or with conversion to AD-type dementia. AD biomarkers were strongly associated with conversion to AD-type dementia, but these relations were not modulated by lifestyle factors. Apolipoprotein E (APOE) genotype did not influence the results. CONCLUSIONS: Later life lifestyle factors had no impact on key AD biomarkers in individuals with SCD and MCI or on conversion to AD-type dementia in MCI. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/29036813/Association_Between_Later_Life_Lifestyle_Factors_and_Alzheimer's_Disease_Biomarkers_in_Non_Demented_Individuals:_A_Longitudinal_Descriptive_Cohort_Study_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-170039 DB - PRIME DP - Unbound Medicine ER -