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Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats.
Ann Nutr Metab 1988; 32(3):169-76AN

Abstract

The effect of age on lipid metabolism was studied in rats fed diets containing safflower oil (SFO, 78% linoleic acid), evening primrose oil (EPO, 9.4% gamma-linolenic acid and 70% linoleic acid) or the mixture of safflower and linseed oil (SLO, 10.2% alpha-linolenic acid and 68% linoleic acid). The activity of hepatic HMG-CoA reductase declined with age in all groups. In adult rats, the reductase activity was high in the EPO group and low in the SLO group. The activity of hepatic cholesterol 7 alpha-hydroxylase was independent of the diet or age. Hepatic delta 6-desaturase activity was low in adult rats fed EPO. In liver microsomal phospholipids, the percentage of 22:5 n-6 decreased while that of 22:6 n-3 increased with age. The ratio of linoleate metabolites to linoleate was high in the EPO group and low in the SLO group. Liver and serum cholesterol increased with age only in rats fed the SLO diet. Thus, the results indicated an enhanced susceptibility to dietary fats with age.

Authors+Show Affiliations

Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuoka, Japan.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2903713

Citation

Choi, Y S., and M Sugano. "Effects of Dietary Alpha- and Gamma-linolenic Acid On Lipid Metabolism in Young and Adult Rats." Annals of Nutrition & Metabolism, vol. 32, no. 3, 1988, pp. 169-76.
Choi YS, Sugano M. Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. Ann Nutr Metab. 1988;32(3):169-76.
Choi, Y. S., & Sugano, M. (1988). Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. Annals of Nutrition & Metabolism, 32(3), pp. 169-76.
Choi YS, Sugano M. Effects of Dietary Alpha- and Gamma-linolenic Acid On Lipid Metabolism in Young and Adult Rats. Ann Nutr Metab. 1988;32(3):169-76. PubMed PMID: 2903713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. AU - Choi,Y S, AU - Sugano,M, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 169 EP - 76 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 32 IS - 3 N2 - The effect of age on lipid metabolism was studied in rats fed diets containing safflower oil (SFO, 78% linoleic acid), evening primrose oil (EPO, 9.4% gamma-linolenic acid and 70% linoleic acid) or the mixture of safflower and linseed oil (SLO, 10.2% alpha-linolenic acid and 68% linoleic acid). The activity of hepatic HMG-CoA reductase declined with age in all groups. In adult rats, the reductase activity was high in the EPO group and low in the SLO group. The activity of hepatic cholesterol 7 alpha-hydroxylase was independent of the diet or age. Hepatic delta 6-desaturase activity was low in adult rats fed EPO. In liver microsomal phospholipids, the percentage of 22:5 n-6 decreased while that of 22:6 n-3 increased with age. The ratio of linoleate metabolites to linoleate was high in the EPO group and low in the SLO group. Liver and serum cholesterol increased with age only in rats fed the SLO diet. Thus, the results indicated an enhanced susceptibility to dietary fats with age. SN - 0250-6807 UR - https://www.unboundmedicine.com/medline/citation/2903713/Effects_of_dietary_alpha__and_gamma_linolenic_acid_on_lipid_metabolism_in_young_and_adult_rats_ L2 - https://www.karger.com?DOI=10.1159/000177430 DB - PRIME DP - Unbound Medicine ER -