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Caenorhabditis elegans Dosage Compensation: Insights into Condensin-Mediated Gene Regulation.
Trends Genet 2018; 34(1):41-53TG

Abstract

Recent work demonstrating the role of chromosome organization in transcriptional regulation has sparked substantial interest in the molecular mechanisms that control chromosome structure. Condensin, an evolutionarily conserved multisubunit protein complex, is essential for chromosome condensation during cell division and functions in regulating gene expression during interphase. In Caenorhabditis elegans, a specialized condensin forms the core of the dosage compensation complex (DCC), which specifically binds to and represses transcription from the hermaphrodite X chromosomes. DCC serves as a clear paradigm for addressing how condensins target large chromosomal domains and how they function to regulate chromosome structure and transcription. Here, we discuss recent research on C. elegans DCC in the context of canonical condensin mechanisms as have been studied in various organisms.

Authors+Show Affiliations

Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY 10003, USA.Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY 10003, USA. Electronic address: se71@nyu.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29037439

Citation

Albritton, Sarah Elizabeth, and Sevinç Ercan. "Caenorhabditis Elegans Dosage Compensation: Insights Into Condensin-Mediated Gene Regulation." Trends in Genetics : TIG, vol. 34, no. 1, 2018, pp. 41-53.
Albritton SE, Ercan S. Caenorhabditis elegans Dosage Compensation: Insights into Condensin-Mediated Gene Regulation. Trends Genet. 2018;34(1):41-53.
Albritton, S. E., & Ercan, S. (2018). Caenorhabditis elegans Dosage Compensation: Insights into Condensin-Mediated Gene Regulation. Trends in Genetics : TIG, 34(1), pp. 41-53. doi:10.1016/j.tig.2017.09.010.
Albritton SE, Ercan S. Caenorhabditis Elegans Dosage Compensation: Insights Into Condensin-Mediated Gene Regulation. Trends Genet. 2018;34(1):41-53. PubMed PMID: 29037439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caenorhabditis elegans Dosage Compensation: Insights into Condensin-Mediated Gene Regulation. AU - Albritton,Sarah Elizabeth, AU - Ercan,Sevinç, Y1 - 2017/10/13/ PY - 2017/07/24/received PY - 2017/09/19/revised PY - 2017/09/25/accepted PY - 2017/10/19/pubmed PY - 2018/11/6/medline PY - 2017/10/18/entrez KW - X chromosome KW - condensin KW - cooperation KW - dosage compensation KW - gene regulation KW - genome organization SP - 41 EP - 53 JF - Trends in genetics : TIG JO - Trends Genet. VL - 34 IS - 1 N2 - Recent work demonstrating the role of chromosome organization in transcriptional regulation has sparked substantial interest in the molecular mechanisms that control chromosome structure. Condensin, an evolutionarily conserved multisubunit protein complex, is essential for chromosome condensation during cell division and functions in regulating gene expression during interphase. In Caenorhabditis elegans, a specialized condensin forms the core of the dosage compensation complex (DCC), which specifically binds to and represses transcription from the hermaphrodite X chromosomes. DCC serves as a clear paradigm for addressing how condensins target large chromosomal domains and how they function to regulate chromosome structure and transcription. Here, we discuss recent research on C. elegans DCC in the context of canonical condensin mechanisms as have been studied in various organisms. SN - 0168-9525 UR - https://www.unboundmedicine.com/medline/citation/29037439/Caenorhabditis_elegans_Dosage_Compensation:_Insights_into_Condensin_Mediated_Gene_Regulation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-9525(17)30170-1 DB - PRIME DP - Unbound Medicine ER -