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Post-training reversible disconnection of the ventral hippocampal-basolateral amygdaloid circuits impairs consolidation of inhibitory avoidance memory in rats.
Learn Mem. 2017 11; 24(11):602-606.LM

Abstract

The ventral hippocampus (VH) and the basolateral amygdala (BLA) are both crucial in inhibitory avoidance (IA) memory. However, the exact role of the VH-BLA circuit in IA memory consolidation is unclear. This study investigated the effect of post-training reversible disconnection of the VH-BLA circuit in IA memory consolidation. Male Wistar rats with implanted guide cannulae were trained with a one-trial IA task, then received immediate intracerebral injections of muscimol or saline, and were tested 24 h later. Muscimol injection into the bilateral BLA, or the unilateral VH and contralateral BLA, but not the unilateral VH and ipsilateral BLA, significantly decreased the retention latencies (versus saline treatment). The results suggest that the VH-BLA circuit could be an important circuit to modulate consolidation of IA memory in rats.

Authors+Show Affiliations

Engineering Research Center of Sustainable Development and Utilization of Biomass Energy, MOE, and Key Laboratory of Yunnan for Biomass Energy and Biotechnology of Environment, School of Life Sciences, Yunnan Normal University, Kunming, 650500, China.National Altitude Training Experimental Demonstrational Center, School of Physical Education, Yunnan Normal University, Kunming, 650500, China.National Altitude Training Experimental Demonstrational Center, School of Physical Education, Yunnan Normal University, Kunming, 650500, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29038222

Citation

Wang, Gong-Wu, et al. "Post-training Reversible Disconnection of the Ventral Hippocampal-basolateral Amygdaloid Circuits Impairs Consolidation of Inhibitory Avoidance Memory in Rats." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 24, no. 11, 2017, pp. 602-606.
Wang GW, Liu J, Wang XQ. Post-training reversible disconnection of the ventral hippocampal-basolateral amygdaloid circuits impairs consolidation of inhibitory avoidance memory in rats. Learn Mem. 2017;24(11):602-606.
Wang, G. W., Liu, J., & Wang, X. Q. (2017). Post-training reversible disconnection of the ventral hippocampal-basolateral amygdaloid circuits impairs consolidation of inhibitory avoidance memory in rats. Learning & Memory (Cold Spring Harbor, N.Y.), 24(11), 602-606. https://doi.org/10.1101/lm.044701.116
Wang GW, Liu J, Wang XQ. Post-training Reversible Disconnection of the Ventral Hippocampal-basolateral Amygdaloid Circuits Impairs Consolidation of Inhibitory Avoidance Memory in Rats. Learn Mem. 2017;24(11):602-606. PubMed PMID: 29038222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Post-training reversible disconnection of the ventral hippocampal-basolateral amygdaloid circuits impairs consolidation of inhibitory avoidance memory in rats. AU - Wang,Gong-Wu, AU - Liu,Jian, AU - Wang,Xiao-Qin, Y1 - 2017/10/16/ PY - 2016/11/30/received PY - 2017/07/10/accepted PY - 2017/10/18/entrez PY - 2017/10/19/pubmed PY - 2018/6/6/medline SP - 602 EP - 606 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 24 IS - 11 N2 - The ventral hippocampus (VH) and the basolateral amygdala (BLA) are both crucial in inhibitory avoidance (IA) memory. However, the exact role of the VH-BLA circuit in IA memory consolidation is unclear. This study investigated the effect of post-training reversible disconnection of the VH-BLA circuit in IA memory consolidation. Male Wistar rats with implanted guide cannulae were trained with a one-trial IA task, then received immediate intracerebral injections of muscimol or saline, and were tested 24 h later. Muscimol injection into the bilateral BLA, or the unilateral VH and contralateral BLA, but not the unilateral VH and ipsilateral BLA, significantly decreased the retention latencies (versus saline treatment). The results suggest that the VH-BLA circuit could be an important circuit to modulate consolidation of IA memory in rats. SN - 1549-5485 UR - https://www.unboundmedicine.com/medline/citation/29038222/Post_training_reversible_disconnection_of_the_ventral_hippocampal_basolateral_amygdaloid_circuits_impairs_consolidation_of_inhibitory_avoidance_memory_in_rats_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29038222/ DB - PRIME DP - Unbound Medicine ER -