Methylene C(sp3)-H Arylation of Aliphatic Ketones Using a Transient Directing Group.ACS Catal. 2017 Oct 06; 7(10):6938-6941.AC
Abstract
Palladium-catalyzed methylene β-C(sp3)-H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp3)-H bond activation.
Links
Pub Type(s)
Journal Article
Language
eng
PubMed ID
29038742
Citation
Hong, Kai, et al. "Methylene C(sp3)-H Arylation of Aliphatic Ketones Using a Transient Directing Group." ACS Catalysis, vol. 7, no. 10, 2017, pp. 6938-6941.
Hong K, Park H, Yu JQ. Methylene C(sp3)-H Arylation of Aliphatic Ketones Using a Transient Directing Group. ACS Catal. 2017;7(10):6938-6941.
Hong, K., Park, H., & Yu, J. Q. (2017). Methylene C(sp3)-H Arylation of Aliphatic Ketones Using a Transient Directing Group. ACS Catalysis, 7(10), 6938-6941. https://doi.org/10.1021/acscatal.7b02905
Hong K, Park H, Yu JQ. Methylene C(sp3)-H Arylation of Aliphatic Ketones Using a Transient Directing Group. ACS Catal. 2017 Oct 6;7(10):6938-6941. PubMed PMID: 29038742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Methylene C(sp3)-H Arylation of Aliphatic Ketones Using a Transient Directing Group.
AU - Hong,Kai,
AU - Park,Hojoon,
AU - Yu,Jin-Quan,
Y1 - 2017/09/13/
PY - 2017/10/18/entrez
PY - 2017/10/19/pubmed
PY - 2017/10/19/medline
KW - C–H activation
KW - arylation
KW - ketone
KW - palladium
KW - transient directing group
KW - β-amino acid
SP - 6938
EP - 6941
JF - ACS catalysis
JO - ACS Catal
VL - 7
IS - 10
N2 - Palladium-catalyzed methylene β-C(sp3)-H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp3)-H bond activation.
SN - 2155-5435
UR - https://www.unboundmedicine.com/medline/citation/29038742/Methylene_C_sp3__H_Arylation_of_Aliphatic_Ketones_Using_a_Transient_Directing_Group_
DB - PRIME
DP - Unbound Medicine
ER -
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