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The protective effect of fish oil lipid emulsions on intestinal failure-associated liver disease in a rat model of short-bowel syndrome.
Pediatr Surg Int. 2018 Feb; 34(2):203-209.PS

Abstract

PURPOSE

Pediatric patients with intestinal failure need long-term parenteral nutrition (PN), but this nutritional support causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD). Several studies have shown that the lipid emulsion produced by soybean oil (SO) is associated with the occurrence of IFALD. In this study, we evaluated the effect of SO and fish oil (FO) lipid emulsion on hepatic steatosis.

METHODS

Sprague-Dawley rats underwent jugular vein catheterization and were divided into three groups: sham operation with normal chow (Sham group), 80% small bowel resection (80% SBR) + TPN with SO lipid emulsion (SO group), and 80% SBR + TPN with FO lipid emulsion (FO group). All rats were euthanized and the serum biochemistry and hepatic histology analyzed.

RESULTS

No significant differences in the serum liver or biliary enzymes were noted between the SO and FO groups. The pathological findings and NAFLD score in the FO group did not show steatosis and were significantly lower than in the SO group. An analysis of the fatty acids profile in the both the SO and FO groups did not indicate essential fatty acid deficiency (EFAD).

CONCLUSION

FO lipid emulsion may have a protective role against steatosis of IFALD without EFAD.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Machigashira S
Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Kaji T
Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Onishi S
Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Yamada W
Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Yano K
Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Yamada K
Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Masuya R
Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Kawano T
Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Nakame K
Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Mukai M
Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
Ieiri S
Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan. sieiri@m.kufm.kagoshima-u.ac.jp.

MeSH

AnimalsDisease Models, AnimalFat Emulsions, IntravenousFish OilsLiver FailureMaleParenteral Nutrition, TotalRatsRats, Sprague-DawleyShort Bowel Syndrome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29039050

Citation

Machigashira, Seiro, et al. "The Protective Effect of Fish Oil Lipid Emulsions On Intestinal Failure-associated Liver Disease in a Rat Model of Short-bowel Syndrome." Pediatric Surgery International, vol. 34, no. 2, 2018, pp. 203-209.
Machigashira S, Kaji T, Onishi S, et al. The protective effect of fish oil lipid emulsions on intestinal failure-associated liver disease in a rat model of short-bowel syndrome. Pediatr Surg Int. 2018;34(2):203-209.
Machigashira, S., Kaji, T., Onishi, S., Yamada, W., Yano, K., Yamada, K., Masuya, R., Kawano, T., Nakame, K., Mukai, M., & Ieiri, S. (2018). The protective effect of fish oil lipid emulsions on intestinal failure-associated liver disease in a rat model of short-bowel syndrome. Pediatric Surgery International, 34(2), 203-209. https://doi.org/10.1007/s00383-017-4190-4
Machigashira S, et al. The Protective Effect of Fish Oil Lipid Emulsions On Intestinal Failure-associated Liver Disease in a Rat Model of Short-bowel Syndrome. Pediatr Surg Int. 2018;34(2):203-209. PubMed PMID: 29039050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The protective effect of fish oil lipid emulsions on intestinal failure-associated liver disease in a rat model of short-bowel syndrome. AU - Machigashira,Seiro, AU - Kaji,Tatsuru, AU - Onishi,Shun, AU - Yamada,Waka, AU - Yano,Keisuke, AU - Yamada,Koji, AU - Masuya,Ryuta, AU - Kawano,Takafumi, AU - Nakame,Kazuhiko, AU - Mukai,Motoi, AU - Ieiri,Satoshi, Y1 - 2017/10/16/ PY - 2017/09/21/accepted PY - 2017/10/19/pubmed PY - 2018/7/17/medline PY - 2017/10/18/entrez KW - Fish oil KW - Intestinal failure-associated liver disease KW - Short-bowel syndrome KW - Soy bean oil SP - 203 EP - 209 JF - Pediatric surgery international JO - Pediatr Surg Int VL - 34 IS - 2 N2 - PURPOSE: Pediatric patients with intestinal failure need long-term parenteral nutrition (PN), but this nutritional support causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD). Several studies have shown that the lipid emulsion produced by soybean oil (SO) is associated with the occurrence of IFALD. In this study, we evaluated the effect of SO and fish oil (FO) lipid emulsion on hepatic steatosis. METHODS: Sprague-Dawley rats underwent jugular vein catheterization and were divided into three groups: sham operation with normal chow (Sham group), 80% small bowel resection (80% SBR) + TPN with SO lipid emulsion (SO group), and 80% SBR + TPN with FO lipid emulsion (FO group). All rats were euthanized and the serum biochemistry and hepatic histology analyzed. RESULTS: No significant differences in the serum liver or biliary enzymes were noted between the SO and FO groups. The pathological findings and NAFLD score in the FO group did not show steatosis and were significantly lower than in the SO group. An analysis of the fatty acids profile in the both the SO and FO groups did not indicate essential fatty acid deficiency (EFAD). CONCLUSION: FO lipid emulsion may have a protective role against steatosis of IFALD without EFAD. SN - 1437-9813 UR - https://www.unboundmedicine.com/medline/citation/29039050/The_protective_effect_of_fish_oil_lipid_emulsions_on_intestinal_failure_associated_liver_disease_in_a_rat_model_of_short_bowel_syndrome_ DB - PRIME DP - Unbound Medicine ER -