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Repeated exposure to 3,4-methylenedioxypyrovalerone and cocaine produces locomotor sensitization with minimal effects on brain monoamines.
Neuropharmacology. 2018 05 15; 134(Pt A):22-27.N

Abstract

Synthetic cathinones, known as "bath salts" on the illicit drug market, pose a significant public health concern. 3,4-Methylenedioxypyrovalerone (MDPV), one of several popular constituents of illicit bath salts, produces similar pharmacological actions to cocaine, albeit with greater potency and efficacy. The present study sought to characterize behavioral and neurochemical effects of repeated exposure to MDPV alone and in combination with cocaine. Male Sprague-Dawley rats were randomly assigned to one the following four treatments, administered once daily for seven days: 1 mg/kg MDPV, 5 mg/kg cocaine, 1 mg/kg MDPV +5 mg/kg cocaine, or saline. Locomotor activity was assessed for 1 h immediately before and 1 h immediately after injections on days 1 and 6. Brains were harvested 20 min after the final injection on day 7 and brain tissue punches were obtained to determine monoamine content within the anterior striatum, medial prefrontal cortex, and nucleus accumbens using High-Performance Liquid Chromatography (HPLC). Drug-induced increases in horizontal activity were significantly greater on treatment day 6 compared to treatment day 1 in all three drug treatment groups in comparison to the saline control group. MDPV produced significantly higher increases in activity compared to either saline or cocaine, although concurrent treatment with MDPV and cocaine produced sub-additive effects. Neurochemical analyses provided no evidence of alterations in total monoamine content following repeated administration of MDPV, cocaine, or the MDPV + COC mixture. Further investigations targeting possible changes in DA receptor sensitivity following repeated exposure to MDPV may help elucidate the mechanistic changes responsible for MDPV-induced behavioral sensitization. This article is part of the Special Issue entitled 'Designer Drugs and Legal Highs.'

Authors+Show Affiliations

Department of Psychology, Western Michigan University, Kalamazoo, MI 49008, United States.Department of Psychiatry and Behavioral Neuroscience, Wayne State University, Detroit, MI 38677, United States.Department of Psychology, Western Michigan University, Kalamazoo, MI 49008, United States. Electronic address: lisa.baker@wmich.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29042316

Citation

Kohler, Robert J., et al. "Repeated Exposure to 3,4-methylenedioxypyrovalerone and Cocaine Produces Locomotor Sensitization With Minimal Effects On Brain Monoamines." Neuropharmacology, vol. 134, no. Pt A, 2018, pp. 22-27.
Kohler RJ, Perrine SA, Baker LE. Repeated exposure to 3,4-methylenedioxypyrovalerone and cocaine produces locomotor sensitization with minimal effects on brain monoamines. Neuropharmacology. 2018;134(Pt A):22-27.
Kohler, R. J., Perrine, S. A., & Baker, L. E. (2018). Repeated exposure to 3,4-methylenedioxypyrovalerone and cocaine produces locomotor sensitization with minimal effects on brain monoamines. Neuropharmacology, 134(Pt A), 22-27. https://doi.org/10.1016/j.neuropharm.2017.10.019
Kohler RJ, Perrine SA, Baker LE. Repeated Exposure to 3,4-methylenedioxypyrovalerone and Cocaine Produces Locomotor Sensitization With Minimal Effects On Brain Monoamines. Neuropharmacology. 2018 05 15;134(Pt A):22-27. PubMed PMID: 29042316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated exposure to 3,4-methylenedioxypyrovalerone and cocaine produces locomotor sensitization with minimal effects on brain monoamines. AU - Kohler,Robert J, AU - Perrine,Shane A, AU - Baker,Lisa E, Y1 - 2017/10/16/ PY - 2017/07/20/received PY - 2017/09/22/revised PY - 2017/10/13/accepted PY - 2017/10/19/pubmed PY - 2018/11/8/medline PY - 2017/10/19/entrez KW - Behavioral sensitization KW - Cocaine KW - Dopamine KW - Locomotor activity KW - MDPV KW - Medial prefrontal cortex KW - Monoamines KW - Nucleus accumbens KW - Rats KW - Serotonin KW - Striatum SP - 22 EP - 27 JF - Neuropharmacology JO - Neuropharmacology VL - 134 IS - Pt A N2 - Synthetic cathinones, known as "bath salts" on the illicit drug market, pose a significant public health concern. 3,4-Methylenedioxypyrovalerone (MDPV), one of several popular constituents of illicit bath salts, produces similar pharmacological actions to cocaine, albeit with greater potency and efficacy. The present study sought to characterize behavioral and neurochemical effects of repeated exposure to MDPV alone and in combination with cocaine. Male Sprague-Dawley rats were randomly assigned to one the following four treatments, administered once daily for seven days: 1 mg/kg MDPV, 5 mg/kg cocaine, 1 mg/kg MDPV +5 mg/kg cocaine, or saline. Locomotor activity was assessed for 1 h immediately before and 1 h immediately after injections on days 1 and 6. Brains were harvested 20 min after the final injection on day 7 and brain tissue punches were obtained to determine monoamine content within the anterior striatum, medial prefrontal cortex, and nucleus accumbens using High-Performance Liquid Chromatography (HPLC). Drug-induced increases in horizontal activity were significantly greater on treatment day 6 compared to treatment day 1 in all three drug treatment groups in comparison to the saline control group. MDPV produced significantly higher increases in activity compared to either saline or cocaine, although concurrent treatment with MDPV and cocaine produced sub-additive effects. Neurochemical analyses provided no evidence of alterations in total monoamine content following repeated administration of MDPV, cocaine, or the MDPV + COC mixture. Further investigations targeting possible changes in DA receptor sensitivity following repeated exposure to MDPV may help elucidate the mechanistic changes responsible for MDPV-induced behavioral sensitization. This article is part of the Special Issue entitled 'Designer Drugs and Legal Highs.' SN - 1873-7064 UR - https://www.unboundmedicine.com/medline/citation/29042316/Repeated_exposure_to_34_methylenedioxypyrovalerone_and_cocaine_produces_locomotor_sensitization_with_minimal_effects_on_brain_monoamines_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(17)30486-0 DB - PRIME DP - Unbound Medicine ER -