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[Co-morbidity of vasovagal syncope and postural tachycardia syndrome with allergic diseases in children].
Beijing Da Xue Xue Bao Yi Xue Ban. 2017 10 18; 49(5):783-788.BD

Abstract

OBJECTIVE

To explore the clinical characteristics of the co-morbidity of vasovagal syncope (VVS) and postural tachycardia syndrome (POTS) with allergic diseases in children.

METHODS

A re-trospective analysis was launched to summarize the clinical data of children with VVS and POTS. They were divided into allergic group and non-allergic group according to the history of allergic diseases. The participants' clinical characteristics were compared between allergic group and non-allergic group using independent sample t test or rank sum test; composition comparisons were completed by Chi-square test. Bi-variate correlation analysis was used to explore the association between eosinophil percentage/count and symptom scores/frequency of syncope episodes. A P value <0.05 was defined as statistically significant.

RESULTS

Sixty-seven children complaining of orthostatic intolerance (43 patients diagnosed as VVS and 24 cases diagnosed as POTS) were enrolled. Totally 21 cases (31%) had allergic diseases, including allergic rhinitis, atopic eczema, asthma, as well as food allergy. And allergic rhinitis is the most common co-morbidity. There were no significant differences between the two groups in age, gender ratio, height, body weight and basement blood pressure. Compared with the non-allergic group, the allergic group showed later onset age (year) (11±2 vs. 9±3, P<0.05) of orthostatic intolerance and shorter course of the diseases (month) [8.0 (0.1, 0.1) vs. 24.0 (0.1, 144.0), P<0.05]. The frequency of syncope episodes in the allergic group among VVS children (times per month) [2.50 (0.08, 30.00) vs. 0.25 (0.03, 5.00), P<0.05] was much higher than that in the non-allergic group. Additionally, the eosinophil percentage (%) [3.50 (0.70, 0.59) vs. 1.65 (0.30, 6.20), P<0.001] and eosinophil count (×109) [0.18 (0.05, 0.71) vs. 0.10 (0.02, 0.38), P<0.001] were increased in the allergic group. However, there were no remarkable differences in the results of head-up tilt test in children with VVS or in the maximum change of heart rate during standing test in children with POTS were involved.

CONCLUSION

Allergic diseases are common co-morbidities in children with both VVS and POTS. Allergic rhinitis is the most common co-morbidity. Children with co-morbidity of VVS/POTS and allergic diseases had a later onset of symptoms of orthostatic intolerance, and were more likely to be hospitalized for intensive attacks of symptoms during a short period when compared with those without allergic diseases. Children diagnosed as VVS combined with allergic diseases had more frequent episodes of syncope.

Authors+Show Affiliations

Liao Y
Department of Pediatrics, Peking University First Hospital, Beijing 100034.
Zhang QY
Department of Pediatrics, Peking University First Hospital, Beijing 100034.
Li HX
Department of Pediatrics, Peking University First Hospital, Beijing 100034.
Wang YL
Department of Pediatrics, Peking University First Hospital, Beijing 100034.
Liu P
Department of Pediatrics, Peking University First Hospital, Beijing 100034.
Du JB
Department of Pediatrics, Peking University First Hospital, Beijing 100034.

MeSH

Blood PressureChildHumansHypersensitivityPostural Orthostatic Tachycardia SyndromeSyncopeSyncope, VasovagalSyndromeTachycardiaTilt-Table Test

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29045956

Citation

Liao, Y, et al. "[Co-morbidity of Vasovagal Syncope and Postural Tachycardia Syndrome With Allergic Diseases in Children]." Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences, vol. 49, no. 5, 2017, pp. 783-788.
Liao Y, Zhang QY, Li HX, et al. [Co-morbidity of vasovagal syncope and postural tachycardia syndrome with allergic diseases in children]. Beijing Da Xue Xue Bao Yi Xue Ban. 2017;49(5):783-788.
Liao, Y., Zhang, Q. Y., Li, H. X., Wang, Y. L., Liu, P., & Du, J. B. (2017). [Co-morbidity of vasovagal syncope and postural tachycardia syndrome with allergic diseases in children]. Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences, 49(5), 783-788.
Liao Y, et al. [Co-morbidity of Vasovagal Syncope and Postural Tachycardia Syndrome With Allergic Diseases in Children]. Beijing Da Xue Xue Bao Yi Xue Ban. 2017 10 18;49(5):783-788. PubMed PMID: 29045956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Co-morbidity of vasovagal syncope and postural tachycardia syndrome with allergic diseases in children]. AU - Liao,Y, AU - Zhang,Q Y, AU - Li,H X, AU - Wang,Y L, AU - Liu,P, AU - Du,J B, PY - 2017/10/19/entrez PY - 2017/10/19/pubmed PY - 2019/2/23/medline SP - 783 EP - 788 JF - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences JO - Beijing Da Xue Xue Bao Yi Xue Ban VL - 49 IS - 5 N2 - OBJECTIVE: To explore the clinical characteristics of the co-morbidity of vasovagal syncope (VVS) and postural tachycardia syndrome (POTS) with allergic diseases in children. METHODS: A re-trospective analysis was launched to summarize the clinical data of children with VVS and POTS. They were divided into allergic group and non-allergic group according to the history of allergic diseases. The participants' clinical characteristics were compared between allergic group and non-allergic group using independent sample t test or rank sum test; composition comparisons were completed by Chi-square test. Bi-variate correlation analysis was used to explore the association between eosinophil percentage/count and symptom scores/frequency of syncope episodes. A P value <0.05 was defined as statistically significant. RESULTS: Sixty-seven children complaining of orthostatic intolerance (43 patients diagnosed as VVS and 24 cases diagnosed as POTS) were enrolled. Totally 21 cases (31%) had allergic diseases, including allergic rhinitis, atopic eczema, asthma, as well as food allergy. And allergic rhinitis is the most common co-morbidity. There were no significant differences between the two groups in age, gender ratio, height, body weight and basement blood pressure. Compared with the non-allergic group, the allergic group showed later onset age (year) (11±2 vs. 9±3, P<0.05) of orthostatic intolerance and shorter course of the diseases (month) [8.0 (0.1, 0.1) vs. 24.0 (0.1, 144.0), P<0.05]. The frequency of syncope episodes in the allergic group among VVS children (times per month) [2.50 (0.08, 30.00) vs. 0.25 (0.03, 5.00), P<0.05] was much higher than that in the non-allergic group. Additionally, the eosinophil percentage (%) [3.50 (0.70, 0.59) vs. 1.65 (0.30, 6.20), P<0.001] and eosinophil count (×109) [0.18 (0.05, 0.71) vs. 0.10 (0.02, 0.38), P<0.001] were increased in the allergic group. However, there were no remarkable differences in the results of head-up tilt test in children with VVS or in the maximum change of heart rate during standing test in children with POTS were involved. CONCLUSION: Allergic diseases are common co-morbidities in children with both VVS and POTS. Allergic rhinitis is the most common co-morbidity. Children with co-morbidity of VVS/POTS and allergic diseases had a later onset of symptoms of orthostatic intolerance, and were more likely to be hospitalized for intensive attacks of symptoms during a short period when compared with those without allergic diseases. Children diagnosed as VVS combined with allergic diseases had more frequent episodes of syncope. SN - 1671-167X UR - https://www.unboundmedicine.com/medline/citation/29045956/[Co_morbidity_of_vasovagal_syncope_and_postural_tachycardia_syndrome_with_allergic_diseases_in_children]_ DB - PRIME DP - Unbound Medicine ER -