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Further evidence that brain histamine H2 receptors are stimulatory in the control of prolactin in the rat.
Acta Endocrinol (Copenh). 1988 Dec; 119(4):488-92.AE

Abstract

The effects of administration into the brain ventricle of H2 receptor agonists (4-methylhistamine, 0.8 mumol/rat; dimaprit, 0.4-0.8 mumol/rat), H2 antagonists (cimetidine, 0.8 mumol/rat; ranitidine, 0.4-0.8 mumol/rat; famotidine, 0.03 mumol/rat) and of the dimaprit chemical analogue SK&F 91487 (0.4 mumol/rat) on unstimulated and histamine-stimulated prolactin secretion in normal male rats were studied. The H2 agonist 4-methylhistamine caused a significant increase in unstimulated blood PRL, whereas dimaprit, SK&F 91487, and the H2 antagonists tested did not change PRL levels. 4-Methylhistamine significantly enhanced the stimulatory effects of histamine on prolactin, whereas all the H2 antagonists inhibited histamine-induced prolactin release. The inhibition of histamine-induced prolactin secretion by the H2 agonist dimaprit is nonspecific, since its chemical analogue SK&F 91487, which has no H2 agonist activity, also inhibits it. These results indicate that stimulation of the H2 receptors in the central nervous system is facilitatory for PRL secretion, suggesting that the activation of H2 receptors may contribute to the PRL-releasing effects of histamine.

Authors+Show Affiliations

Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, University of Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2904722

Citation

Netti, C, et al. "Further Evidence That Brain Histamine H2 Receptors Are Stimulatory in the Control of Prolactin in the Rat." Acta Endocrinologica, vol. 119, no. 4, 1988, pp. 488-92.
Netti C, Sibilia V, Guidobono F, et al. Further evidence that brain histamine H2 receptors are stimulatory in the control of prolactin in the rat. Acta Endocrinol. 1988;119(4):488-92.
Netti, C., Sibilia, V., Guidobono, F., Villa, I., Franco, P., & Pecile, A. (1988). Further evidence that brain histamine H2 receptors are stimulatory in the control of prolactin in the rat. Acta Endocrinologica, 119(4), 488-92.
Netti C, et al. Further Evidence That Brain Histamine H2 Receptors Are Stimulatory in the Control of Prolactin in the Rat. Acta Endocrinol. 1988;119(4):488-92. PubMed PMID: 2904722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further evidence that brain histamine H2 receptors are stimulatory in the control of prolactin in the rat. AU - Netti,C, AU - Sibilia,V, AU - Guidobono,F, AU - Villa,I, AU - Franco,P, AU - Pecile,A, PY - 1988/12/1/pubmed PY - 1988/12/1/medline PY - 1988/12/1/entrez SP - 488 EP - 92 JF - Acta endocrinologica JO - Acta Endocrinol. VL - 119 IS - 4 N2 - The effects of administration into the brain ventricle of H2 receptor agonists (4-methylhistamine, 0.8 mumol/rat; dimaprit, 0.4-0.8 mumol/rat), H2 antagonists (cimetidine, 0.8 mumol/rat; ranitidine, 0.4-0.8 mumol/rat; famotidine, 0.03 mumol/rat) and of the dimaprit chemical analogue SK&F 91487 (0.4 mumol/rat) on unstimulated and histamine-stimulated prolactin secretion in normal male rats were studied. The H2 agonist 4-methylhistamine caused a significant increase in unstimulated blood PRL, whereas dimaprit, SK&F 91487, and the H2 antagonists tested did not change PRL levels. 4-Methylhistamine significantly enhanced the stimulatory effects of histamine on prolactin, whereas all the H2 antagonists inhibited histamine-induced prolactin release. The inhibition of histamine-induced prolactin secretion by the H2 agonist dimaprit is nonspecific, since its chemical analogue SK&F 91487, which has no H2 agonist activity, also inhibits it. These results indicate that stimulation of the H2 receptors in the central nervous system is facilitatory for PRL secretion, suggesting that the activation of H2 receptors may contribute to the PRL-releasing effects of histamine. SN - 0001-5598 UR - https://www.unboundmedicine.com/medline/citation/2904722/Further_evidence_that_brain_histamine_H2_receptors_are_stimulatory_in_the_control_of_prolactin_in_the_rat_ DB - PRIME DP - Unbound Medicine ER -