Tags

Type your tag names separated by a space and hit enter

High Fat Diet with a High Monounsaturated Fatty Acid and Polyunsaturated/Saturated Fatty Acid Ratio Suppresses Body Fat Accumulation and Weight Gain in Obese Hamsters.
Nutrients 2017; 9(10)N

Abstract

The aim of this study was to investigate the effect of a high fat diet with experimental oil consisting of 60% MUFAs (monounsaturated fatty acids) with a P/S ratio of 5 on fat deposition and lipid metabolism in obese hamsters. Hamsters were randomly assigned to a control group and a diet-induced obesity group for nine weeks. Then an additional eight-week experimental period began, during which obese hamsters were randomly divided into three groups and fed different amounts of the experimental oil mixture in their diets as follows: 5%, 15%, and 20% w/w (OB-M5, OB-M15, and OB-M20 groups, respectively). The results showed that the OB-M15 and OB-M20 groups had significantly lower blood cholesterol and higher insulin levels. Compared to the control group, the three obese groups exhibited higher hepatic fatty acid synthase activity; however, the acyl-CoA oxidase activities were also enhanced. Although dietary fat content differed, there were no differences in energy intake, final body weights, and epididymal fat weights among the four groups. These results suggest that regardless of whether the specimens had a high fat intake or not, dietary fat containing high MUFAs with a high P/S ratio had beneficial effects on maintaining blood lipid profiles and may not result in body fat accumulation in obese hamsters, possibly by promoting lipolytic enzyme activities.

Authors+Show Affiliations

School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan. sokei@tmu.edu.tw. Research Center of Geriatric Nutrition, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan. sokei@tmu.edu.tw. Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 11031, Taiwan. sokei@tmu.edu.tw.School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan. lin5611@tmu.edu.tw. Research Center of Geriatric Nutrition, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan. lin5611@tmu.edu.tw.School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan. susanchang@tmu.edu.tw. Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 11031, Taiwan. susanchang@tmu.edu.tw.School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan. ychien@tmu.edu.tw. Research Center of Geriatric Nutrition, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan. ychien@tmu.edu.tw. Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 11031, Taiwan. ychien@tmu.edu.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29048361

Citation

Yang, Suh-Ching, et al. "High Fat Diet With a High Monounsaturated Fatty Acid and Polyunsaturated/Saturated Fatty Acid Ratio Suppresses Body Fat Accumulation and Weight Gain in Obese Hamsters." Nutrients, vol. 9, no. 10, 2017.
Yang SC, Lin SH, Chang JS, et al. High Fat Diet with a High Monounsaturated Fatty Acid and Polyunsaturated/Saturated Fatty Acid Ratio Suppresses Body Fat Accumulation and Weight Gain in Obese Hamsters. Nutrients. 2017;9(10).
Yang, S. C., Lin, S. H., Chang, J. S., & Chien, Y. W. (2017). High Fat Diet with a High Monounsaturated Fatty Acid and Polyunsaturated/Saturated Fatty Acid Ratio Suppresses Body Fat Accumulation and Weight Gain in Obese Hamsters. Nutrients, 9(10), doi:10.3390/nu9101148.
Yang SC, et al. High Fat Diet With a High Monounsaturated Fatty Acid and Polyunsaturated/Saturated Fatty Acid Ratio Suppresses Body Fat Accumulation and Weight Gain in Obese Hamsters. Nutrients. 2017 Oct 19;9(10) PubMed PMID: 29048361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High Fat Diet with a High Monounsaturated Fatty Acid and Polyunsaturated/Saturated Fatty Acid Ratio Suppresses Body Fat Accumulation and Weight Gain in Obese Hamsters. AU - Yang,Suh-Ching, AU - Lin,Shyh-Hsiang, AU - Chang,Jung-Su, AU - Chien,Yi-Wen, Y1 - 2017/10/19/ PY - 2017/08/29/received PY - 2017/10/07/revised PY - 2017/10/16/accepted PY - 2017/10/20/entrez PY - 2017/10/20/pubmed PY - 2018/7/12/medline KW - acyl-CoA oxidase KW - diet-induced obesity KW - fat accumulation KW - monounsaturated fatty acids JF - Nutrients JO - Nutrients VL - 9 IS - 10 N2 - The aim of this study was to investigate the effect of a high fat diet with experimental oil consisting of 60% MUFAs (monounsaturated fatty acids) with a P/S ratio of 5 on fat deposition and lipid metabolism in obese hamsters. Hamsters were randomly assigned to a control group and a diet-induced obesity group for nine weeks. Then an additional eight-week experimental period began, during which obese hamsters were randomly divided into three groups and fed different amounts of the experimental oil mixture in their diets as follows: 5%, 15%, and 20% w/w (OB-M5, OB-M15, and OB-M20 groups, respectively). The results showed that the OB-M15 and OB-M20 groups had significantly lower blood cholesterol and higher insulin levels. Compared to the control group, the three obese groups exhibited higher hepatic fatty acid synthase activity; however, the acyl-CoA oxidase activities were also enhanced. Although dietary fat content differed, there were no differences in energy intake, final body weights, and epididymal fat weights among the four groups. These results suggest that regardless of whether the specimens had a high fat intake or not, dietary fat containing high MUFAs with a high P/S ratio had beneficial effects on maintaining blood lipid profiles and may not result in body fat accumulation in obese hamsters, possibly by promoting lipolytic enzyme activities. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/29048361/High_Fat_Diet_with_a_High_Monounsaturated_Fatty_Acid_and_Polyunsaturated/Saturated_Fatty_Acid_Ratio_Suppresses_Body_Fat_Accumulation_and_Weight_Gain_in_Obese_Hamsters_ L2 - http://www.mdpi.com/resolver?pii=nu9101148 DB - PRIME DP - Unbound Medicine ER -