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A Quantitative Analysis of Microcirculation in Skin Defects Covered with Topical Wound Dressings or a Newly Developed Collagen Matrix.
Adv Skin Wound Care 2017; 30(11):517-521AS

Abstract

OBJECTIVE

Innovative skin substitutes and temporary wound dressings are frequently used in the treatment of superficial and partial-thickness wounds. The aim of this study was to compare 2 commonly used temporary skin dressings with a newly developed collagen matrix to determine changes in microcirculation as measured by blood flow, hemoglobin oxygenation, and relative hemoglobin values during healing of partial-thickness skin defects.

METHODS

This animal study involved 28 adult male Lewis rats. On the back of each rat, 2 standardized partial-thickness skin defects were generated through a skin dermatome (n = 56). Then, wounds were treated with polylactide-based copolymer skin substitute (Suprathel, PolyMedics, Denkendorf, Germany; n = 14), biosynthetic skin dressing (Biobrane, Smith & Nephew, Hamburg, Germany; n = 14), or Collagen Cell Carrier (CCC; Naturin Viscofan, Weinheim, Germany; n = 14). The remaining control wounds were left untreated (n = 14).

MAIN OUTCOME MEASURES

Perfusion dynamics were assessed every 10 days for 80 days with the O2C device (LEA Medizintechnik, Gieβen, Germany) to determine blood flow, hemoglobin oxygenation, and relative amount of hemoglobin.

MAIN RESULTS

Blood flow was increased in all wounds for at least 30 days after wound generation. The relative amounts of hemoglobin were increased in superficial layers (2 mm) for 10 to 20 days. Hemoglobin oxygenation in the superficial layers decreased in the polylactide-based copolymer skin substitute and biosynthetic skin dressing-treated groups and initially increased in the untreated wounds and CCC groups on day 10; these values also decreased.

CONCLUSIONS

The presented results demonstrate the complex changes in microcirculation in the course of healing partial-thickness wounds with different wound dressings and contribute to a better understanding of these wounds. However, based on the results of the study, a clear recommendation for a specific substitute is not yet possible.

Authors+Show Affiliations

Manuel Held, MD, is a resident; Fabian Medved, MD, is a consultant; Wiebke Petersen, MD, is a resident; Dascha Sophie Tolzmann, MD, is a resident; Hans-Eberhard Schaller, MD, is Department Head; and Jens Rothenberger, MD, is a consultant, all at the BG-Trauma Center, Department of Plastic and Hand Surgery, Reconstructive and Aesthetic Surgery, Eberhard Karls University, Tuebingen, Germany. Afshin Rahmanian-Schwarz, MD, is Department Head, Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, Clinic Traunstein, Traunstein, Bavaria, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29049260

Citation

Held, Manuel, et al. "A Quantitative Analysis of Microcirculation in Skin Defects Covered With Topical Wound Dressings or a Newly Developed Collagen Matrix." Advances in Skin & Wound Care, vol. 30, no. 11, 2017, pp. 517-521.
Held M, Medved F, Petersen W, et al. A Quantitative Analysis of Microcirculation in Skin Defects Covered with Topical Wound Dressings or a Newly Developed Collagen Matrix. Adv Skin Wound Care. 2017;30(11):517-521.
Held, M., Medved, F., Petersen, W., Tolzmann, D. S., Rahmanian-Schwarz, A., Schaller, H. E., & Rothenberger, J. (2017). A Quantitative Analysis of Microcirculation in Skin Defects Covered with Topical Wound Dressings or a Newly Developed Collagen Matrix. Advances in Skin & Wound Care, 30(11), pp. 517-521. doi:10.1097/01.ASW.0000525848.21221.b8.
Held M, et al. A Quantitative Analysis of Microcirculation in Skin Defects Covered With Topical Wound Dressings or a Newly Developed Collagen Matrix. Adv Skin Wound Care. 2017;30(11):517-521. PubMed PMID: 29049260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Quantitative Analysis of Microcirculation in Skin Defects Covered with Topical Wound Dressings or a Newly Developed Collagen Matrix. AU - Held,Manuel, AU - Medved,Fabian, AU - Petersen,Wiebke, AU - Tolzmann,Dascha Sophie, AU - Rahmanian-Schwarz,Afshin, AU - Schaller,Hans-Eberhard, AU - Rothenberger,Jens, PY - 2017/10/20/entrez PY - 2017/10/20/pubmed PY - 2018/10/26/medline SP - 517 EP - 521 JF - Advances in skin & wound care JO - Adv Skin Wound Care VL - 30 IS - 11 N2 - OBJECTIVE: Innovative skin substitutes and temporary wound dressings are frequently used in the treatment of superficial and partial-thickness wounds. The aim of this study was to compare 2 commonly used temporary skin dressings with a newly developed collagen matrix to determine changes in microcirculation as measured by blood flow, hemoglobin oxygenation, and relative hemoglobin values during healing of partial-thickness skin defects. METHODS: This animal study involved 28 adult male Lewis rats. On the back of each rat, 2 standardized partial-thickness skin defects were generated through a skin dermatome (n = 56). Then, wounds were treated with polylactide-based copolymer skin substitute (Suprathel, PolyMedics, Denkendorf, Germany; n = 14), biosynthetic skin dressing (Biobrane, Smith & Nephew, Hamburg, Germany; n = 14), or Collagen Cell Carrier (CCC; Naturin Viscofan, Weinheim, Germany; n = 14). The remaining control wounds were left untreated (n = 14). MAIN OUTCOME MEASURES: Perfusion dynamics were assessed every 10 days for 80 days with the O2C device (LEA Medizintechnik, Gieβen, Germany) to determine blood flow, hemoglobin oxygenation, and relative amount of hemoglobin. MAIN RESULTS: Blood flow was increased in all wounds for at least 30 days after wound generation. The relative amounts of hemoglobin were increased in superficial layers (2 mm) for 10 to 20 days. Hemoglobin oxygenation in the superficial layers decreased in the polylactide-based copolymer skin substitute and biosynthetic skin dressing-treated groups and initially increased in the untreated wounds and CCC groups on day 10; these values also decreased. CONCLUSIONS: The presented results demonstrate the complex changes in microcirculation in the course of healing partial-thickness wounds with different wound dressings and contribute to a better understanding of these wounds. However, based on the results of the study, a clear recommendation for a specific substitute is not yet possible. SN - 1538-8654 UR - https://www.unboundmedicine.com/medline/citation/29049260/A_Quantitative_Analysis_of_Microcirculation_in_Skin_Defects_Covered_with_Topical_Wound_Dressings_or_a_Newly_Developed_Collagen_Matrix_ L2 - http://dx.doi.org/10.1097/01.ASW.0000525848.21221.b8 DB - PRIME DP - Unbound Medicine ER -