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Prenatal Air Pollution and Newborns' Predisposition to Accelerated Biological Aging.
JAMA Pediatr. 2017 12 01; 171(12):1160-1167.JP

Abstract

Importance

Telomere length is a marker of biological aging that may provide a cellular memory of exposures to oxidative stress and inflammation. Telomere length at birth has been related to life expectancy. An association between prenatal air pollution exposure and telomere length at birth could provide new insights in the environmental influence on molecular longevity.

Objective

To assess the association of prenatal exposure to particulate matter (PM) with newborn telomere length as reflected by cord blood and placental telomere length.

Design, Setting, and Participants

In a prospective birth cohort (ENVIRONAGE [Environmental Influence on Ageing in Early Life]), a total of 730 mother-newborn pairs were recruited in Flanders, Belgium between February 2010 and December 2014, all with a singleton full-term birth (≥37 weeks of gestation). For statistical analysis, participants with full data on both cord blood and placental telomere lengths were included, resulting in a final study sample size of 641.

Exposures

Maternal residential PM2.5 (particles with an aerodynamic diameter ≤2.5 μm) exposure during pregnancy.

Main Outcomes and Measures

In the newborns, cord blood and placental tissue relative telomere length were measured. Maternal residential PM2.5 exposure during pregnancy was estimated using a high-resolution spatial-temporal interpolation method. In distributed lag models, both cord blood and placental telomere length were associated with average weekly exposures to PM2.5 during pregnancy, allowing the identification of critical sensitive exposure windows.

Results

In 641 newborns, cord blood and placental telomere length were significantly and inversely associated with PM2.5 exposure during midgestation (weeks 12-25 for cord blood and weeks 15-27 for placenta). A 5-µg/m3 increment in PM2.5 exposure during the entire pregnancy was associated with 8.8% (95% CI, -14.1% to -3.1%) shorter cord blood leukocyte telomeres and 13.2% (95% CI, -19.3% to -6.7%) shorter placental telomere length. These associations were controlled for date of delivery, gestational age, maternal body mass index, maternal age, paternal age, newborn sex, newborn ethnicity, season of delivery, parity, maternal smoking status, maternal educational level, pregnancy complications, and ambient temperature.

Conclusions and Relevance

Mothers who were exposed to higher levels of PM2.5 gave birth to newborns with shorter telomere length. The observed telomere loss in newborns by prenatal air pollution exposure indicates less buffer for postnatal influences of factors decreasing telomere length during life. Therefore, improvements in air quality may promote molecular longevity from birth onward.

Authors+Show Affiliations

Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium. Instituto de Salud Global, Centre for Research in Environmental Epidemiology, Barcelona, Spain. Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.Department of Social and Environmental Health Research, London School of Hygiene & Tropical Medicine (LSHTM), London, England. Department of Medical Statistics, LSHTM, London, England.Belgian Interregional Environment Agency, Brussels, Belgium.Flemish Institute for Technological Research, Mol, Belgium.Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium. Louvain Centre for Toxicology and Applied Pharmacology, Université catholique de Louvain, Brussels, Belgium.Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium. Department of Public Health & Primary Care, Leuven University, Leuven, Belgium.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29049509

Citation

Martens, Dries S., et al. "Prenatal Air Pollution and Newborns' Predisposition to Accelerated Biological Aging." JAMA Pediatrics, vol. 171, no. 12, 2017, pp. 1160-1167.
Martens DS, Cox B, Janssen BG, et al. Prenatal Air Pollution and Newborns' Predisposition to Accelerated Biological Aging. JAMA Pediatr. 2017;171(12):1160-1167.
Martens, D. S., Cox, B., Janssen, B. G., Clemente, D. B. P., Gasparrini, A., Vanpoucke, C., Lefebvre, W., Roels, H. A., Plusquin, M., & Nawrot, T. S. (2017). Prenatal Air Pollution and Newborns' Predisposition to Accelerated Biological Aging. JAMA Pediatrics, 171(12), 1160-1167. https://doi.org/10.1001/jamapediatrics.2017.3024
Martens DS, et al. Prenatal Air Pollution and Newborns' Predisposition to Accelerated Biological Aging. JAMA Pediatr. 2017 12 1;171(12):1160-1167. PubMed PMID: 29049509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal Air Pollution and Newborns' Predisposition to Accelerated Biological Aging. AU - Martens,Dries S, AU - Cox,Bianca, AU - Janssen,Bram G, AU - Clemente,Diana B P, AU - Gasparrini,Antonio, AU - Vanpoucke,Charlotte, AU - Lefebvre,Wouter, AU - Roels,Harry A, AU - Plusquin,Michelle, AU - Nawrot,Tim S, PY - 2017/10/20/pubmed PY - 2017/12/13/medline PY - 2017/10/20/entrez SP - 1160 EP - 1167 JF - JAMA pediatrics JO - JAMA Pediatr VL - 171 IS - 12 N2 - Importance: Telomere length is a marker of biological aging that may provide a cellular memory of exposures to oxidative stress and inflammation. Telomere length at birth has been related to life expectancy. An association between prenatal air pollution exposure and telomere length at birth could provide new insights in the environmental influence on molecular longevity. Objective: To assess the association of prenatal exposure to particulate matter (PM) with newborn telomere length as reflected by cord blood and placental telomere length. Design, Setting, and Participants: In a prospective birth cohort (ENVIRONAGE [Environmental Influence on Ageing in Early Life]), a total of 730 mother-newborn pairs were recruited in Flanders, Belgium between February 2010 and December 2014, all with a singleton full-term birth (≥37 weeks of gestation). For statistical analysis, participants with full data on both cord blood and placental telomere lengths were included, resulting in a final study sample size of 641. Exposures: Maternal residential PM2.5 (particles with an aerodynamic diameter ≤2.5 μm) exposure during pregnancy. Main Outcomes and Measures: In the newborns, cord blood and placental tissue relative telomere length were measured. Maternal residential PM2.5 exposure during pregnancy was estimated using a high-resolution spatial-temporal interpolation method. In distributed lag models, both cord blood and placental telomere length were associated with average weekly exposures to PM2.5 during pregnancy, allowing the identification of critical sensitive exposure windows. Results: In 641 newborns, cord blood and placental telomere length were significantly and inversely associated with PM2.5 exposure during midgestation (weeks 12-25 for cord blood and weeks 15-27 for placenta). A 5-µg/m3 increment in PM2.5 exposure during the entire pregnancy was associated with 8.8% (95% CI, -14.1% to -3.1%) shorter cord blood leukocyte telomeres and 13.2% (95% CI, -19.3% to -6.7%) shorter placental telomere length. These associations were controlled for date of delivery, gestational age, maternal body mass index, maternal age, paternal age, newborn sex, newborn ethnicity, season of delivery, parity, maternal smoking status, maternal educational level, pregnancy complications, and ambient temperature. Conclusions and Relevance: Mothers who were exposed to higher levels of PM2.5 gave birth to newborns with shorter telomere length. The observed telomere loss in newborns by prenatal air pollution exposure indicates less buffer for postnatal influences of factors decreasing telomere length during life. Therefore, improvements in air quality may promote molecular longevity from birth onward. SN - 2168-6211 UR - https://www.unboundmedicine.com/medline/citation/29049509/Prenatal_Air_Pollution_and_Newborns'_Predisposition_to_Accelerated_Biological_Aging_ L2 - https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2017.3024 DB - PRIME DP - Unbound Medicine ER -